# Hexapeptide and tri-ceramide complex

Page: https://lovi.care/skincare/ingredients/hexapeptide-and-tri-ceramide-complex

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Work well together

Use them together in the same routine, applying the [tri-ceramide complex](https://lovi.care/skincare/ingredients/tri-ceramide-complex) first and the [hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide) right after, because the lipids help the peptides absorb better. The ceramides help repair and strengthen your skin barrier while the peptides firm and smooth the surface. If your skin feels sensitive, you can apply them on alternate nights or wait a few minutes between steps.

- [All about hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide)
- [All about tri-ceramide complex](https://lovi.care/skincare/ingredients/tri-ceramide-complex)

### [Hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide) products

- [SkinCeuticals P-TOX](https://lovi.care/skincare/p/skinceuticals/p-tox/for/mature-skin) — High fit

### [Tri-ceramide complex](https://lovi.care/skincare/ingredients/tri-ceramide-complex) products

- [BYOMA Hydrating Serum](https://lovi.care/skincare/p/byoma/hydrating-serum/for/dry-sensitive-skin) — Superior fit — [$16.99 at Amazon](https://www.amazon.com/dp/B0GZHTTKQ6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [BYOMA Moisturizing Gel-Cream](https://lovi.care/skincare/p/byoma/moisturizing-gel-cream/for/mature-skin) — High fit — [$14.99 at Amazon](https://www.amazon.com/dp/B0BJ74DJXG?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [BYOMA Creamy Jelly Cleanser](https://lovi.care/skincare/p/byoma/creamy-jelly-cleanser/for/dry-skin) — High fit — [$10.49 at Amazon](https://www.amazon.com/dp/B0BTYBVLFW?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [BYOMA Brightening Serum](https://lovi.care/skincare/p/byoma/brightening-serum/for/dry-skin) — High fit — [$15.99 at Amazon](https://www.amazon.com/dp/B0C7C7ZBG9?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [BYOMA Balancing Face Mist](https://lovi.care/skincare/p/byoma/balancing-face-mist/for/dry-skin) — Superior fit — [$11.29 at Amazon](https://www.amazon.com/dp/B0C7C8D9LS?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [BYOMA Milky Moisture Cleanser](https://lovi.care/skincare/p/byoma/milky-moisture-cleanser/for/dry-skin) — Superior fit — [$12.99 at Amazon](https://www.amazon.com/dp/B0CSDXL86L?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [BYOMA Clarifying Serum](https://lovi.care/skincare/p/byoma/clarifying-serum/for/dry-skin) — High fit — [$15.99 at Amazon](https://www.amazon.com/dp/B0C7C8BZLM?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [BYOMA Moisturizing Rich Cream](https://lovi.care/skincare/p/byoma/moisturizing-rich-cream/for/dry-skin) — Superior fit — [$12.79 at Amazon](https://www.amazon.com/dp/B0BZX2RLNX?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [BYOMA De-Puff + Brighten Eye Gel](https://lovi.care/skincare/p/byoma/de-puff-brighten-eye-gel/for/dry-skin) — High fit — [$10.49 at Amazon](https://www.amazon.com/dp/B0C7C7DDT3?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use hexapeptide and tri-ceramide complex together?

[Hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide) and [tri-ceramide complex](https://lovi.care/skincare/ingredients/tri-ceramide-complex) work well together because the lipids improve peptide absorption while reinforcing skin structure. Combining them helps enhance barrier repair and support dry, mature, or barrier-impaired skin.

[American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### Which goes first, hexapeptide or tri-ceramide complex?

There is no strict rule on which goes first between hexapeptide and tri-ceramide complex, as combining them enhances skin repair and barrier support. You can apply either ingredient first depending on your product textures, usually starting with the lighter [serum](https://lovi.care/skincare/ingredients/serum) and finishing with the richer cream.

### Are hexapeptide and tri-ceramide complex good for sensitive skin?

Hexapeptide and tri-ceramide complex work well together to enhance repair and barrier support, making them beneficial for dry, mature, or barrier-impaired skin. Combining these ingredients helps improve absorption and reinforce skin structure.

## Research on hexapeptide and tri-ceramide complex

- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013
- [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019

## Other combinations

- Work well together: [Benzoyl peroxide and tri-ceramide complex](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-tri-ceramide-complex)
- Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/ingredients/adapalene-and-hexapeptide)
- Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/ingredients/hexapeptide-and-granactive-retinoid)
- Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/hexapeptide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/ingredients/hexapeptide-and-pro-retinol)
- Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/ingredients/hexapeptide-and-retinal)
- Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/ingredients/hexapeptide-and-retinoid-blend)
- Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/ingredients/retinol-and-hexapeptide)
- Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/ingredients/tretinoin-and-hexapeptide)
- Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/ingredients/hexapeptide-and-vitamin-a)
- Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/ingredients/hexapeptide-and-liposome)
- Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/ingredients/hexapeptide-and-microcapsule)
- Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/ingredients/vitamin-c-and-hexapeptide)
- Work well together: [Niacinamide and tri-ceramide complex](https://lovi.care/skincare/ingredients/niacinamide-and-tri-ceramide-complex)
- Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/ingredients/hexapeptide-and-betaine)
- Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/ingredients/glycerin-and-hexapeptide)
- Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-hyaluronic-acid)
- Work well together: [Liposome and tri-ceramide complex](https://lovi.care/skincare/ingredients/liposome-and-tri-ceramide-complex)
- Work well together: [Tri-ceramide complex and multi-lamellar emulsion](https://lovi.care/skincare/ingredients/tri-ceramide-complex-and-multi-lamellar-emulsion)
- Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/ingredients/niacinamide-and-hexapeptide)
- Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/ingredients/panthenol-and-hexapeptide)
- Work well together: [Betaine and tri-ceramide complex](https://lovi.care/skincare/ingredients/betaine-and-tri-ceramide-complex)
- Work well together: [Glycerin and tri-ceramide complex](https://lovi.care/skincare/ingredients/glycerin-and-tri-ceramide-complex)
- Work well together: [Hyaluronic acid and tri-ceramide complex](https://lovi.care/skincare/ingredients/hyaluronic-acid-and-tri-ceramide-complex)
- Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/ingredients/bakuchiol-and-hexapeptide)
- Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/ingredients/hexapeptide-and-arginine)
- Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/ingredients/hexapeptide-and-gaba)
- Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/ingredients/hexapeptide-and-silk-amino-acids)
- Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/ingredients/hexapeptide-and-taurine)
- Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/ingredients/hexapeptide-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide)
- Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/ingredients/hexapeptide-and-citric-acid)
- Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/ingredients/glycolic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-lactic-acid)
- Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/ingredients/coenzyme-q10-and-hexapeptide)
- Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/ingredients/green-tea-and-hexapeptide)
- Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/ingredients/vitamin-e-and-hexapeptide)
- Work well together: [Coenzyme Q10 and tri-ceramide complex](https://lovi.care/skincare/ingredients/coenzyme-q10-and-tri-ceramide-complex)
- Work well together: [Green tea and tri-ceramide complex](https://lovi.care/skincare/ingredients/green-tea-and-tri-ceramide-complex)
- Work well together: [Vitamin E and tri-ceramide complex](https://lovi.care/skincare/ingredients/vitamin-e-and-tri-ceramide-complex)
- Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex)
- Work well together: [Bio-placenta peptides and tri-ceramide complex](https://lovi.care/skincare/ingredients/bio-placenta-peptides-and-tri-ceramide-complex)
- Work well together: [Collagen peptide and tri-ceramide complex](https://lovi.care/skincare/ingredients/collagen-peptide-and-tri-ceramide-complex)
- Work well together: [Copper peptide and tri-ceramide complex](https://lovi.care/skincare/ingredients/copper-peptide-and-tri-ceramide-complex)
- Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/ingredients/hexapeptide-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/ingredients/ceramide-building-complex-and-hexapeptide)
- Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/ingredients/hexapeptide-and-cholesterol)
- Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/ingredients/hexapeptide-and-phytosphingosine)
- Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/ingredients/hexapeptide-and-phytosterol)
- Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/ingredients/hexapeptide-and-squalene)
- Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/ingredients/hexapeptide-9-and-tri-ceramide-complex)
- Work well together: [Tri-ceramide complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/ingredients/tri-ceramide-complex-and-palmitoyl-pentapeptide-4)
- Work well together: [Tri-ceramide complex and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/tri-ceramide-complex-and-palmitoyl-tripeptide-1)
- Work well together: [Peptide-rich plasma and tri-ceramide complex](https://lovi.care/skincare/ingredients/peptide-rich-plasma-and-tri-ceramide-complex)
- Work well together: [Tri-ceramide complex and triple peptide blend](https://lovi.care/skincare/ingredients/tri-ceramide-complex-and-triple-peptide-blend)
- Work well together: [Bakuchiol and tri-ceramide complex](https://lovi.care/skincare/ingredients/bakuchiol-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/ingredients/salicylic-acid-and-hexapeptide)
- Keep them apart: [AHA blend glycolic and citric acids and tri-ceramide complex](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-tri-ceramide-complex)
- Keep them apart: [Citric acid and tri-ceramide complex](https://lovi.care/skincare/ingredients/citric-acid-and-tri-ceramide-complex)
- Keep them apart: [Glycolic acid and tri-ceramide complex](https://lovi.care/skincare/ingredients/glycolic-acid-and-tri-ceramide-complex)
- Keep them apart: [Lactic acid and tri-ceramide complex](https://lovi.care/skincare/ingredients/lactic-acid-and-tri-ceramide-complex)
- Keep them apart: [Mandelic acid and tri-ceramide complex](https://lovi.care/skincare/ingredients/mandelic-acid-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and tri-ceramide complex](https://lovi.care/skincare/ingredients/salicylic-acid-and-tri-ceramide-complex)
- Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/ingredients/hexapeptide-and-baking-soda)
- Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/ingredients/hexapeptide-and-bleach)
- Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/ingredients/hexapeptide-and-potassium-hydroxide)
- Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-isopropyl-alcohol)
- Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-polyvinyl-alcohol)
- Keep them apart: [Bergamot oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/bergamot-oil-and-tri-ceramide-complex)
- Keep them apart: [Camphor oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/camphor-oil-and-tri-ceramide-complex)
- Keep them apart: [Chamomile oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/chamomile-oil-and-tri-ceramide-complex)
- Keep them apart: [Clove leaf oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/clove-leaf-oil-and-tri-ceramide-complex)
- Keep them apart: [Eucalyptus oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/eucalyptus-oil-and-tri-ceramide-complex)
- Keep them apart: [Tri-ceramide complex and geranium oil](https://lovi.care/skincare/ingredients/tri-ceramide-complex-and-geranium-oil)
- Keep them apart: [Grapefruit peel oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/grapefruit-peel-oil-and-tri-ceramide-complex)
- Keep them apart: [Lavender oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/lavender-oil-and-tri-ceramide-complex)
- Keep them apart: [Lemon oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/lemon-oil-and-tri-ceramide-complex)
- Keep them apart: [Orange oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/orange-oil-and-tri-ceramide-complex)
- Keep them apart: [Palmarosa oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/palmarosa-oil-and-tri-ceramide-complex)
- Keep them apart: [Peppermint oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/peppermint-oil-and-tri-ceramide-complex)
- Keep them apart: [Rose oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/rose-oil-and-tri-ceramide-complex)
- Keep them apart: [Rosewood oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/rosewood-oil-and-tri-ceramide-complex)
- Keep them apart: [Sandalwood oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/sandalwood-oil-and-tri-ceramide-complex)
- Keep them apart: [Tea tree oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/tea-tree-oil-and-tri-ceramide-complex)
- Keep them apart: [Thyme oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/thyme-oil-and-tri-ceramide-complex)
- Keep them apart: [Wild mint oil and tri-ceramide complex](https://lovi.care/skincare/ingredients/wild-mint-oil-and-tri-ceramide-complex)
- Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/ingredients/hexapeptide-and-copper)
- Work well together: [Cholesterol and tri-ceramide complex](https://lovi.care/skincare/ingredients/cholesterol-and-tri-ceramide-complex)
- Work well together: [Lauric acid and tri-ceramide complex](https://lovi.care/skincare/ingredients/lauric-acid-and-tri-ceramide-complex)
- Work well together: [Linoleic acid and tri-ceramide complex](https://lovi.care/skincare/ingredients/linoleic-acid-and-tri-ceramide-complex)
- Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/ingredients/hexapeptide-and-magnesium)
- Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/ingredients/hexapeptide-and-zinc)
- Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/ingredients/hexapeptide-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-hexapeptide)
- Work well together: [Allantoin and tri-ceramide complex](https://lovi.care/skincare/ingredients/allantoin-and-tri-ceramide-complex)
- Work well together: [Bisabolol and tri-ceramide complex](https://lovi.care/skincare/ingredients/bisabolol-and-tri-ceramide-complex)
- Work well together: [Panthenol and tri-ceramide complex](https://lovi.care/skincare/ingredients/panthenol-and-tri-ceramide-complex)
- Work well together: [Retinol and tri-ceramide complex](https://lovi.care/skincare/ingredients/retinol-and-tri-ceramide-complex)
- Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/ingredients/azelaic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/ingredients/hexapeptide-and-protease)
- Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/ingredients/hexapeptide-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/hexapeptide-and-tri-ceramide-complex (this page)
- United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-and-tri-ceramide-complex
- Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-and-tri-ceramide-complex
- Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-and-tri-ceramide-complex
- France: https://lovi.care/skincare/fr/ingredients/hexapeptide-and-tri-ceramide-complex
- Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-and-tri-ceramide-complex
- Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-and-tri-ceramide-complex
- Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-and-tri-ceramide-complex
- Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-and-tri-ceramide-complex
- Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-and-tri-ceramide-complex
- Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-and-tri-ceramide-complex
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-and-tri-ceramide-complex
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-and-tri-ceramide-complex