# Hexapeptide and mandelic acid

Page: https://lovi.care/skincare/ingredients/hexapeptide-and-mandelic-acid

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Keep them apart

Use them at different times of day by applying [mandelic acid](https://lovi.care/skincare/ingredients/mandelic-acid) in the morning and [hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide) at night, because acid breaks down the peptide. The acid is too harsh and ruins the peptide, making it stop working for your skin. You can fix this by using them in separate routines or waiting longer between them.

- [All about hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide)
- [All about mandelic acid](https://lovi.care/skincare/ingredients/mandelic-acid)

### [Hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide) products

- [SkinCeuticals P-TOX](https://lovi.care/skincare/p/skinceuticals/p-tox/for/mature-skin) — High fit

### [Mandelic acid](https://lovi.care/skincare/ingredients/mandelic-acid) products

- [The Ordinary Mandelic Acid 10% + HA](https://lovi.care/skincare/p/the-ordinary/mandelic-acid-10-ha/for/acne-prone-skin) — Superior fit — [$7.80 at Amazon](https://www.amazon.com/dp/B07BGJMNYL?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Nécessaire The Body Retinol](https://lovi.care/skincare/p/necessaire/the-body-retinol/for/dark-spots) — Average fit
- [Good Molecules Mandelic Acid Serum](https://lovi.care/skincare/p/good-molecules/mandelic-acid-serum/for/dry-sensitive-skin) — Superior fit — [$9.99 at Amazon](https://www.amazon.com/dp/B0D6TWLB6T?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Glamglow Supermud Clearing Treatment](https://lovi.care/skincare/p/glamglow/supermud-clearing-treatment/for/oily-skin) — High fit — [$42.00 at Amazon](https://www.amazon.com/dp/B07DHSKYXR?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Dermalogica PowerBright Dark Spot Peel](https://lovi.care/skincare/p/dermalogica/powerbright-dark-spot-peel/for/oily-skin) — Average fit
- [Sofie Pavitt Face Mandelic Clearing Serum](https://lovi.care/skincare/p/sofie-pavitt-face/mandelic-clearing-serum/for/oily-acne-prone-skin) — High fit — [$84.00 at Amazon](https://www.amazon.com/dp/B0HKXKCTC6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Cetaphil Gentle Exfoliating SA Lotion](https://lovi.care/skincare/p/cetaphil/gentle-exfoliating-sa-lotion/for/combination-skin) — High fit — [$10.97 at Amazon](https://www.amazon.com/dp/B0CZDP1Q9H?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [SkinCeuticals Cell Cycle Catalyst](https://lovi.care/skincare/p/skinceuticals/cell-cycle-catalyst/for/oily-acne-prone-skin) — Average fit
- [DIME TBT Serum](https://lovi.care/skincare/p/dime/tbt-serum/for/dry-sensitive-skin) — High fit
- [By Wishtrend Mandelic Acid 5% Skin Prep Water](https://lovi.care/skincare/p/by-wishtrend/mandelic-acid-5-skin-prep-water/for/acne-prone-skin) — High fit — [$17.90 at Amazon](https://www.amazon.com/dp/B07MC4P4R8?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Haruharu Wonder Black Rice Triple AHA Gentle Cleansing Gel](https://lovi.care/skincare/p/haruharu-wonder/black-rice-triple-aha-gentle-cleansing-gel/for/oily-acne-prone-skin) — High fit — [$13.99 at Amazon](https://www.amazon.com/dp/B0CKVL9PGY?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Neutrogena Bright Boost Gel Cream](https://lovi.care/skincare/p/neutrogena/bright-boost-gel-cream/for/acne-prone-skin) — High fit

## Questions and answers

### Can you use hexapeptide and mandelic acid together?

Keep [hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide) and [mandelic acid](https://lovi.care/skincare/ingredients/mandelic-acid) apart in your routine because the low pH of mandelic acid destabilizes peptide bonds and reduces their bioactivity. Use them in separate steps or routines, such as applying mandelic acid in the morning and hexapeptide in the evening.

### Which goes first, hexapeptide or mandelic acid?

Keep hexapeptide and mandelic acid apart by using them in separate steps or routines, such as AM and PM, because the low pH of mandelic acid can destabilize hexapeptide. Using them together may reduce the bioactivity of the peptide.

### Are hexapeptide and mandelic acid good for sensitive skin?

Hexapeptide and mandelic acid should be kept apart in your routine because the acidic environment of mandelic acid destabilizes peptides. Use mandelic acid in a separate step or routine, such as AM and PM separation, especially for sensitive skin.

## Research on hexapeptide and mandelic acid

- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013
- [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017
- [Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/31553119/) Mandelic acid · Journal of Cosmetic Dermatology, 2020
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019
- [Chemical peels for acne vulgaris: a systematic review of randomised controlled trials](https://pubmed.ncbi.nlm.nih.gov/29705755/) Mandelic acid · BMJ Open, 2018

## Other combinations

- Keep them apart: [Benzoyl peroxide and mandelic acid](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-mandelic-acid)
- Keep them apart: [Retinol and mandelic acid](https://lovi.care/skincare/ingredients/retinol-and-mandelic-acid)
- Depends on the strength: [Niacinamide and mandelic acid](https://lovi.care/skincare/ingredients/niacinamide-and-mandelic-acid)
- Work well together: [Mandelic acid and sodium lactate](https://lovi.care/skincare/ingredients/mandelic-acid-and-sodium-lactate)
- Work well together: [Mandelic acid and tromethamine](https://lovi.care/skincare/ingredients/mandelic-acid-and-tromethamine)
- Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/ingredients/adapalene-and-hexapeptide)
- Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/ingredients/hexapeptide-and-granactive-retinoid)
- Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/hexapeptide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/ingredients/hexapeptide-and-pro-retinol)
- Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/ingredients/hexapeptide-and-retinal)
- Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/ingredients/hexapeptide-and-retinoid-blend)
- Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/ingredients/retinol-and-hexapeptide)
- Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/ingredients/tretinoin-and-hexapeptide)
- Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/ingredients/hexapeptide-and-vitamin-a)
- Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/ingredients/hexapeptide-and-liposome)
- Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/ingredients/hexapeptide-and-microcapsule)
- Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/ingredients/vitamin-c-and-hexapeptide)
- Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/ingredients/hexapeptide-and-betaine)
- Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/ingredients/glycerin-and-hexapeptide)
- Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-hyaluronic-acid)
- Work well together: [Mandelic acid and betaine](https://lovi.care/skincare/ingredients/mandelic-acid-and-betaine)
- Work well together: [Glycerin and mandelic acid](https://lovi.care/skincare/ingredients/glycerin-and-mandelic-acid)
- Depends on the strength: [Mandelic acid and hyaluronic acid](https://lovi.care/skincare/ingredients/mandelic-acid-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/ingredients/niacinamide-and-hexapeptide)
- Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/ingredients/panthenol-and-hexapeptide)
- Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/ingredients/bakuchiol-and-hexapeptide)
- Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/ingredients/hexapeptide-and-arginine)
- Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/ingredients/hexapeptide-and-gaba)
- Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/ingredients/hexapeptide-and-silk-amino-acids)
- Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/ingredients/hexapeptide-and-taurine)
- Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/ingredients/hexapeptide-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide)
- Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/ingredients/hexapeptide-and-citric-acid)
- Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/ingredients/glycolic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-lactic-acid)
- Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-mandelic-acid)
- Keep them apart: [Bio-placenta peptides and mandelic acid](https://lovi.care/skincare/ingredients/bio-placenta-peptides-and-mandelic-acid)
- Keep them apart: [Carnosine and mandelic acid](https://lovi.care/skincare/ingredients/carnosine-and-mandelic-acid)
- Keep them apart: [Mandelic acid and collagen peptide](https://lovi.care/skincare/ingredients/mandelic-acid-and-collagen-peptide)
- Keep them apart: [Mandelic acid and copper peptide](https://lovi.care/skincare/ingredients/mandelic-acid-and-copper-peptide)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/ingredients/mandelic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ingredients/mandelic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Mandelic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/mandelic-acid-and-palmitoyl-tripeptide-1)
- Keep them apart: [Mandelic acid and peptide-rich plasma](https://lovi.care/skincare/ingredients/mandelic-acid-and-peptide-rich-plasma)
- Keep them apart: [Mandelic acid and triple peptide blend](https://lovi.care/skincare/ingredients/mandelic-acid-and-triple-peptide-blend)
- Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/ingredients/coenzyme-q10-and-hexapeptide)
- Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/ingredients/green-tea-and-hexapeptide)
- Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/ingredients/vitamin-e-and-hexapeptide)
- Keep them apart: [Adapalene and mandelic acid](https://lovi.care/skincare/ingredients/adapalene-and-mandelic-acid)
- Keep them apart: [Mandelic acid and granactive retinoid](https://lovi.care/skincare/ingredients/mandelic-acid-and-granactive-retinoid)
- Keep them apart: [Mandelic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/mandelic-acid-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and mandelic acid](https://lovi.care/skincare/ingredients/pro-retinol-and-mandelic-acid)
- Keep them apart: [Retinal and mandelic acid](https://lovi.care/skincare/ingredients/retinal-and-mandelic-acid)
- Keep them apart: [Mandelic acid and retinoid blend](https://lovi.care/skincare/ingredients/mandelic-acid-and-retinoid-blend)
- Keep them apart: [Tretinoin and mandelic acid](https://lovi.care/skincare/ingredients/tretinoin-and-mandelic-acid)
- Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/ingredients/hexapeptide-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/ingredients/ceramide-building-complex-and-hexapeptide)
- Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/ingredients/hexapeptide-and-cholesterol)
- Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/ingredients/hexapeptide-and-phytosphingosine)
- Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/ingredients/hexapeptide-and-phytosterol)
- Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/ingredients/hexapeptide-and-squalene)
- Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/ingredients/hexapeptide-and-tri-ceramide-complex)
- Work well together: [Mandelic acid and gluconolactone](https://lovi.care/skincare/ingredients/mandelic-acid-and-gluconolactone)
- Work well together: [Mandelic acid and lactobionic acid](https://lovi.care/skincare/ingredients/mandelic-acid-and-lactobionic-acid)
- Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/ingredients/salicylic-acid-and-hexapeptide)
- Work well together: [Mandelic acid and cholesterol](https://lovi.care/skincare/ingredients/mandelic-acid-and-cholesterol)
- Work well together: [Mandelic acid and lauric acid](https://lovi.care/skincare/ingredients/mandelic-acid-and-lauric-acid)
- Work well together: [Linoleic acid and mandelic acid](https://lovi.care/skincare/ingredients/linoleic-acid-and-mandelic-acid)
- Keep them apart: [Mandelic acid and tri-ceramide complex](https://lovi.care/skincare/ingredients/mandelic-acid-and-tri-ceramide-complex)
- Work well together: [Arginine and mandelic acid](https://lovi.care/skincare/ingredients/arginine-and-mandelic-acid)
- Work well together: [Mandelic acid and GABA](https://lovi.care/skincare/ingredients/mandelic-acid-and-gaba)
- Work well together: [Silk amino acids and mandelic acid](https://lovi.care/skincare/ingredients/silk-amino-acids-and-mandelic-acid)
- Work well together: [Taurine and mandelic acid](https://lovi.care/skincare/ingredients/taurine-and-mandelic-acid)
- Work well together: [Mandelic acid and theanine](https://lovi.care/skincare/ingredients/mandelic-acid-and-theanine)
- Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/ingredients/hexapeptide-and-baking-soda)
- Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/ingredients/hexapeptide-and-bleach)
- Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/ingredients/hexapeptide-and-potassium-hydroxide)
- Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-isopropyl-alcohol)
- Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-polyvinyl-alcohol)
- Work well together: [Ferulic acid and mandelic acid](https://lovi.care/skincare/ingredients/ferulic-acid-and-mandelic-acid)
- Work well together: [Vitamin E and mandelic acid](https://lovi.care/skincare/ingredients/vitamin-e-and-mandelic-acid)
- Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/ingredients/hexapeptide-and-copper)
- Keep them apart: [Azelaic acid and mandelic acid](https://lovi.care/skincare/ingredients/azelaic-acid-and-mandelic-acid)
- Keep them apart: [Salicylic acid and mandelic acid](https://lovi.care/skincare/ingredients/salicylic-acid-and-mandelic-acid)
- Work well together: [Allantoin and mandelic acid](https://lovi.care/skincare/ingredients/allantoin-and-mandelic-acid)
- Work well together: [Mandelic acid and bisabolol](https://lovi.care/skincare/ingredients/mandelic-acid-and-bisabolol)
- Work well together: [Panthenol and mandelic acid](https://lovi.care/skincare/ingredients/panthenol-and-mandelic-acid)
- Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/ingredients/hexapeptide-and-magnesium)
- Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/ingredients/hexapeptide-and-zinc)
- Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/ingredients/hexapeptide-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-hexapeptide)
- Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/ingredients/azelaic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/ingredients/hexapeptide-and-protease)
- Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/ingredients/hexapeptide-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/hexapeptide-and-mandelic-acid (this page)
- United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-and-mandelic-acid
- Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-and-mandelic-acid
- Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-and-mandelic-acid
- France: https://lovi.care/skincare/fr/ingredients/hexapeptide-and-mandelic-acid
- Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-and-mandelic-acid
- Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-and-mandelic-acid
- Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-and-mandelic-acid
- Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-and-mandelic-acid
- Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-and-mandelic-acid
- Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-and-mandelic-acid
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-and-mandelic-acid
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-and-mandelic-acid