# Hexapeptide and hydroxypinacolone retinoate Page: https://lovi.care/skincare/ingredients/hexapeptide-and-hydroxypinacolone-retinoate The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States. Keep them apart Use them at different times of day by applying your peptide product in the morning and your [hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate) at night. Using both active ingredients together can cause extra skin irritation because they are both very strong treatments. You can prevent this by switching to a gentler formula or waiting longer between applying them. - [All about hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide) - [All about hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate) ### [Hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide) products - [SkinCeuticals P-TOX](https://lovi.care/skincare/p/skinceuticals/p-tox/for/mature-skin) — High fit ### [Hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate) products - [The Ordinary Granactive Retinoid 2% Emulsion](https://lovi.care/skincare/p/the-ordinary/granactive-retinoid-2-emulsion/for/oily-skin) — High fit — [$12.10 at Amazon](https://www.amazon.com/dp/B071HHSMTT?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) - [IOPE Retinol Super Bounce Serum](https://lovi.care/skincare/p/iope/retinol-super-bounce-serum/for/dark-spots) — Average fit — [$49.00 at Amazon](https://www.amazon.com/dp/B0GNTW9PPM?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) - [BYOMA Sensitive Retinol Oil](https://lovi.care/skincare/p/byoma/sensitive-retinol-oil/for/dry-skin) — Average fit — [$17.99 at Amazon](https://www.amazon.com/dp/B0CSDWY381?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) - [Medicube Deep Vita A Retinol Serum](https://lovi.care/skincare/p/medicube/deep-vita-a-retinol-serum/for/acne-prone-skin) — Average fit - [Sunday Riley A+ High-Dose Retinoid Serum](https://lovi.care/skincare/p/sunday-riley/a-high-dose-retinoid-serum/for/oily-acne-prone-skin) — High fit — [$50.00 at Amazon](https://www.amazon.com/dp/B0B7JT39KP?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use hexapeptide and hydroxypinacolone retinoate together? Keep [hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide) and [hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate) apart in your routine because combined stimulation may increase skin irritation. Instead, alternate your usage by applying your retinoid in the evening and peptides in the morning. ### Which goes first, hexapeptide or hydroxypinacolone retinoate? Keep hexapeptide and hydroxypinacolone retinoate apart in your routine because combined stimulation may increase irritation. Alternate their usage by applying hydroxypinacolone retinoate in the evening and hexapeptide in the morning. ### Are hexapeptide and hydroxypinacolone retinoate good for sensitive skin? Keep hexapeptide and hydroxypinacolone retinoate apart in your routine because combined stimulation may increase irritation, making them less ideal to use together on sensitive skin. Alternate their usage by applying your retinoid in the evening and peptides in the morning. ## Research on hexapeptide and hydroxypinacolone retinoate - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013 - [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019 - [Characterization of Acne-Prone Skin with Reflectance Confocal Microscopy and Optical Coherence Tomography and Modifications Induced by Topical Treatment and Probiotic Supplementation](https://pubmed.ncbi.nlm.nih.gov/37510902/) Hydroxypinacolone retinoate · Journal of Clinical Medicine, 2023 - [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023 - [Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging](https://pubmed.ncbi.nlm.nih.gov/39394831/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025 ## Other combinations - Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate) - Keep them apart: [Bio-placenta peptides and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate) - Keep them apart: [Hydroxypinacolone retinoate and collagen peptide](https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate-and-collagen-peptide) - Keep them apart: [Hydroxypinacolone retinoate and copper peptide](https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate-and-copper-peptide) - Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/ingredients/adapalene-and-hexapeptide) - Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/ingredients/hexapeptide-and-granactive-retinoid) - Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/ingredients/hexapeptide-and-pro-retinol) - Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/ingredients/hexapeptide-and-retinal) - Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/ingredients/hexapeptide-and-retinoid-blend) - Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/ingredients/retinol-and-hexapeptide) - Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/ingredients/tretinoin-and-hexapeptide) - Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/ingredients/hexapeptide-and-vitamin-a) - Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9) - Keep them apart: [Hydroxypinacolone retinoate and palmitoyl pentapeptide-4](https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-pentapeptide-4) - Keep them apart: [Hydroxypinacolone retinoate and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-tripeptide-1) - Keep them apart: [Hydroxypinacolone retinoate and peptide-rich plasma](https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate-and-peptide-rich-plasma) - Keep them apart: [Hydroxypinacolone retinoate and triple peptide blend](https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate-and-triple-peptide-blend) - Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/ingredients/hexapeptide-and-liposome) - Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/ingredients/hexapeptide-and-microcapsule) - Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/ingredients/vitamin-c-and-hexapeptide) - Depends on the strength: [Niacinamide and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/niacinamide-and-hydroxypinacolone-retinoate) - Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/ingredients/hexapeptide-and-betaine) - Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/ingredients/glycerin-and-hexapeptide) - Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/ingredients/niacinamide-and-hexapeptide) - Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/ingredients/panthenol-and-hexapeptide) - Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/ingredients/bakuchiol-and-hexapeptide) - Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/ingredients/hexapeptide-and-arginine) - Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/ingredients/hexapeptide-and-gaba) - Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/ingredients/hexapeptide-and-silk-amino-acids) - Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/ingredients/hexapeptide-and-taurine) - Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/ingredients/hexapeptide-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide) - Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/ingredients/hexapeptide-and-citric-acid) - Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/ingredients/glycolic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-lactic-acid) - Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-mandelic-acid) - Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/ingredients/coenzyme-q10-and-hexapeptide) - Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/ingredients/green-tea-and-hexapeptide) - Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/ingredients/vitamin-e-and-hexapeptide) - Keep them apart: [AHA blend glycolic and citric acids and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-hydroxypinacolone-retinoate) - Keep them apart: [Hydroxypinacolone retinoate and citric acid](https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate-and-citric-acid) - Keep them apart: [Glycolic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/glycolic-acid-and-hydroxypinacolone-retinoate) - Keep them apart: [Lactic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/lactic-acid-and-hydroxypinacolone-retinoate) - Keep them apart: [Mandelic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/mandelic-acid-and-hydroxypinacolone-retinoate) - Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/ingredients/hexapeptide-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/ingredients/ceramide-building-complex-and-hexapeptide) - Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/ingredients/hexapeptide-and-cholesterol) - Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/ingredients/hexapeptide-and-phytosphingosine) - Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/ingredients/hexapeptide-and-phytosterol) - Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/ingredients/hexapeptide-and-squalene) - Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/ingredients/hexapeptide-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/ingredients/salicylic-acid-and-hexapeptide) - Keep them apart: [Salicylic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/salicylic-acid-and-hydroxypinacolone-retinoate) - Keep them apart: [Vitamin C and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/vitamin-c-and-hydroxypinacolone-retinoate) - Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/ingredients/hexapeptide-and-baking-soda) - Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/ingredients/hexapeptide-and-bleach) - Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/ingredients/hexapeptide-and-potassium-hydroxide) - Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-behenyl-alcohol) - Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-isopropyl-alcohol) - Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-polyvinyl-alcohol) - Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/ingredients/hexapeptide-and-copper) - Keep them apart: [Benzoyl peroxide and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-hydroxypinacolone-retinoate) - Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/ingredients/hexapeptide-and-magnesium) - Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/ingredients/hexapeptide-and-zinc) - Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/ingredients/hexapeptide-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-hexapeptide) - Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/ingredients/azelaic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/ingredients/hexapeptide-and-protease) - Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/ingredients/hexapeptide-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/hexapeptide-and-hydroxypinacolone-retinoate (this page) - United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-and-hydroxypinacolone-retinoate - Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-and-hydroxypinacolone-retinoate - Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-and-hydroxypinacolone-retinoate - France: https://lovi.care/skincare/fr/ingredients/hexapeptide-and-hydroxypinacolone-retinoate - Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-and-hydroxypinacolone-retinoate - Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-and-hydroxypinacolone-retinoate - Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-and-hydroxypinacolone-retinoate - Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-and-hydroxypinacolone-retinoate - Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-and-hydroxypinacolone-retinoate - Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-and-hydroxypinacolone-retinoate - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-and-hydroxypinacolone-retinoate - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-and-hydroxypinacolone-retinoate