# Hexapeptide and GABA

Page: https://lovi.care/skincare/ingredients/hexapeptide-and-gaba

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Work well together

Use them together in the same routine, because they team up to hydrate and repair your skin. Amino acids help your skin absorb peptides better, making them more effective at smoothing and hydrating. You do not need to change anything since this combination is gentle and works well together.

- [All about hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide)
- [All about GABA](https://lovi.care/skincare/ingredients/gaba)

### [Hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide) products

- [SkinCeuticals P-TOX](https://lovi.care/skincare/p/skinceuticals/p-tox/for/mature-skin) — High fit

### [GABA](https://lovi.care/skincare/ingredients/gaba) products

- [Revision Skincare Revox™ Line Relaxer](https://lovi.care/skincare/p/revision-skincare/revoxtm-line-relaxer/for/mature-skin) — High fit

## Questions and answers

### Can you use hexapeptide and GABA together?

Yes, [hexapeptide](https://lovi.care/skincare/ingredients/hexapeptide) and [GABA](https://lovi.care/skincare/ingredients/gaba) work well together to support structural protein synthesis and moisture balance, making them beneficial for hydrating and reparative complexes suitable for all skin types.

### Which goes first, hexapeptide or GABA?

Hexapeptide and GABA work well together when paired in hydrating and reparative complexes, and neither ingredient has a strict rule for which must go first.

### Are hexapeptide and GABA good for sensitive skin?

Hexapeptide and GABA work well together because amino acids and natural moisturizing factor components pair well with peptides to support moisture balance in all skin types. Hexapeptide treatment twice daily may help reduce wrinkles and skin roughness. Lovi gives this combination an Average fit.

[American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

## Research on hexapeptide and GABA

- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013
- [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019

## Other combinations

- Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/ingredients/adapalene-and-hexapeptide)
- Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/ingredients/hexapeptide-and-granactive-retinoid)
- Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/hexapeptide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/ingredients/hexapeptide-and-pro-retinol)
- Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/ingredients/hexapeptide-and-retinal)
- Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/ingredients/hexapeptide-and-retinoid-blend)
- Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/ingredients/retinol-and-hexapeptide)
- Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/ingredients/tretinoin-and-hexapeptide)
- Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/ingredients/hexapeptide-and-vitamin-a)
- Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/ingredients/hexapeptide-and-liposome)
- Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/ingredients/hexapeptide-and-microcapsule)
- Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/ingredients/vitamin-c-and-hexapeptide)
- Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/ingredients/hexapeptide-and-betaine)
- Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/ingredients/glycerin-and-hexapeptide)
- Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/ingredients/niacinamide-and-hexapeptide)
- Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/ingredients/panthenol-and-hexapeptide)
- Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/ingredients/bakuchiol-and-hexapeptide)
- Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-gaba)
- Work well together: [Bio-placenta peptides and GABA](https://lovi.care/skincare/ingredients/bio-placenta-peptides-and-gaba)
- Work well together: [Collagen peptide and GABA](https://lovi.care/skincare/ingredients/collagen-peptide-and-gaba)
- Work well together: [Copper peptide and GABA](https://lovi.care/skincare/ingredients/copper-peptide-and-gaba)
- Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/ingredients/hexapeptide-and-arginine)
- Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/ingredients/hexapeptide-and-silk-amino-acids)
- Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/ingredients/hexapeptide-and-taurine)
- Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/ingredients/hexapeptide-and-theanine)
- Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/ingredients/hexapeptide-9-and-gaba)
- Work well together: [GABA and palmitoyl pentapeptide-4](https://lovi.care/skincare/ingredients/gaba-and-palmitoyl-pentapeptide-4)
- Work well together: [GABA and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/gaba-and-palmitoyl-tripeptide-1)
- Work well together: [Peptide-rich plasma and GABA](https://lovi.care/skincare/ingredients/peptide-rich-plasma-and-gaba)
- Work well together: [Triple peptide blend and GABA](https://lovi.care/skincare/ingredients/triple-peptide-blend-and-gaba)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide)
- Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/ingredients/hexapeptide-and-citric-acid)
- Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/ingredients/glycolic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-lactic-acid)
- Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/ingredients/hexapeptide-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/ingredients/coenzyme-q10-and-hexapeptide)
- Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/ingredients/green-tea-and-hexapeptide)
- Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/ingredients/vitamin-e-and-hexapeptide)
- Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/ingredients/hexapeptide-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/ingredients/ceramide-building-complex-and-hexapeptide)
- Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/ingredients/hexapeptide-and-cholesterol)
- Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/ingredients/hexapeptide-and-phytosphingosine)
- Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/ingredients/hexapeptide-and-phytosterol)
- Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/ingredients/hexapeptide-and-squalene)
- Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/ingredients/hexapeptide-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/ingredients/salicylic-acid-and-hexapeptide)
- Work well together: [AHA blend glycolic and citric acids and GABA](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-gaba)
- Work well together: [Citric acid and GABA](https://lovi.care/skincare/ingredients/citric-acid-and-gaba)
- Work well together: [Glycolic acid and GABA](https://lovi.care/skincare/ingredients/glycolic-acid-and-gaba)
- Work well together: [Lactic acid and GABA](https://lovi.care/skincare/ingredients/lactic-acid-and-gaba)
- Work well together: [Mandelic acid and GABA](https://lovi.care/skincare/ingredients/mandelic-acid-and-gaba)
- Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/ingredients/hexapeptide-and-baking-soda)
- Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/ingredients/hexapeptide-and-bleach)
- Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/ingredients/hexapeptide-and-potassium-hydroxide)
- Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-isopropyl-alcohol)
- Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-and-polyvinyl-alcohol)
- Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/ingredients/hexapeptide-and-copper)
- Work well together: [Hyaluronic acid and GABA](https://lovi.care/skincare/ingredients/hyaluronic-acid-and-gaba)
- Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/ingredients/hexapeptide-and-magnesium)
- Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/ingredients/hexapeptide-and-zinc)
- Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/ingredients/hexapeptide-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-hexapeptide)
- Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/ingredients/azelaic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/ingredients/hexapeptide-and-protease)
- Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/ingredients/hexapeptide-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/hexapeptide-and-gaba (this page)
- United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-and-gaba
- Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-and-gaba
- Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-and-gaba
- France: https://lovi.care/skincare/fr/ingredients/hexapeptide-and-gaba
- Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-and-gaba
- Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-and-gaba
- Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-and-gaba
- Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-and-gaba
- Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-and-gaba
- Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-and-gaba
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-and-gaba
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-and-gaba