# Hexapeptide-9 and baking soda

Page: https://lovi.care/skincare/ingredients/hexapeptide-9-and-baking-soda

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Keep them apart

Use them at different times of day, applying the peptide first and the [baking soda](https://lovi.care/skincare/ingredients/baking-soda) later, because the baking soda is too harsh for the peptide. Baking soda makes the skin's surface too basic, which stops the peptide from working and can cause irritation or dryness. You can switch to a gentler cleanser or wait longer between using them.

- [All about hexapeptide-9](https://lovi.care/skincare/ingredients/hexapeptide-9)
- [All about baking soda](https://lovi.care/skincare/ingredients/baking-soda)

### [Hexapeptide-9](https://lovi.care/skincare/ingredients/hexapeptide-9) products

- [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [$153.00 at Amazon](https://www.amazon.com/dp/B00175YVOS?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit
- [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [$19.44 at Amazon](https://www.amazon.com/dp/B095YHYF33?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

### [Baking soda](https://lovi.care/skincare/ingredients/baking-soda) products

- [By Wishtrend Green Tea & Enzyme Powder Wash](https://lovi.care/skincare/p/by-wishtrend/green-tea-and-enzyme-powder-wash/for/sensitive-skin) — High fit — [$15.80 at Amazon](https://www.amazon.com/dp/B09H73T814?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [HISTOLAB Soft Deep Cleansing Enzyme Powder Wash](https://lovi.care/skincare/p/histolab/soft-deep-cleansing-enzyme-powder-wash/for/dark-spots) — High fit — [$25.00 at Amazon](https://www.amazon.com/dp/B07F1GGTRS?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Vichy Mineralizing Thermal Water](https://lovi.care/skincare/p/vichy/mineralizing-thermal-water/for/sensitive-skin) — High fit

## Questions and answers

### Can you use hexapeptide-9 and baking soda together?

No, you should keep [hexapeptide-9](https://lovi.care/skincare/ingredients/hexapeptide-9) and [baking soda](https://lovi.care/skincare/ingredients/baking-soda) apart in your routine because peptides lose stability and activity in the highly alkaline environment of baking soda. This high pH causes deamidation and oxidation that can ruin the peptide formula.

### Which goes first, hexapeptide-9 or baking soda?

Keep hexapeptide-9 and baking soda apart in your routine because baking soda creates a highly alkaline environment that causes peptides to lose their stability and activity.

### Are hexapeptide-9 and baking soda good for sensitive skin?

No, you should keep hexapeptide-9 and baking soda apart in your routine because baking soda creates a highly alkaline environment that causes peptides to lose stability and activity. Lovi rates the compatibility of these two ingredients as low.

## Research on hexapeptide-9 and baking soda

- [Evaluation of vulvar irritancy potential of a menstrual pad containing sodium bicarbonate in short-term application](https://pubmed.ncbi.nlm.nih.gov/1658321/) Baking soda · The Journal of Reproductive Medicine, 1991
- [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025

## Other combinations

- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/ingredients/granactive-retinoid-and-hexapeptide-9)
- Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9)
- Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/ingredients/pro-retinol-and-hexapeptide-9)
- Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/ingredients/retinal-and-hexapeptide-9)
- Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/ingredients/retinoid-blend-and-hexapeptide-9)
- Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/ingredients/retinol-and-hexapeptide-9)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/ingredients/vitamin-a-and-hexapeptide-9)
- Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/ingredients/liposome-and-hexapeptide-9)
- Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/ingredients/microcapsule-and-hexapeptide-9)
- Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/ingredients/vitamin-c-and-hexapeptide-9)
- Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/ingredients/betaine-and-hexapeptide-9)
- Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/ingredients/glycerin-and-hexapeptide-9)
- Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/ingredients/hyaluronic-acid-and-hexapeptide-9)
- Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/ingredients/niacinamide-and-hexapeptide-9)
- Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/ingredients/panthenol-and-hexapeptide-9)
- Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/ingredients/bakuchiol-and-hexapeptide-9)
- Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/ingredients/arginine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/ingredients/hexapeptide-9-and-gaba)
- Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/ingredients/silk-amino-acids-and-hexapeptide-9)
- Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/ingredients/taurine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/ingredients/hexapeptide-9-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9)
- Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/ingredients/citric-acid-and-hexapeptide-9)
- Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/ingredients/glycolic-acid-and-hexapeptide-9)
- Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/ingredients/lactic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/ingredients/mandelic-acid-and-hexapeptide-9)
- Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/ingredients/coenzyme-q10-and-hexapeptide-9)
- Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/ingredients/green-tea-and-hexapeptide-9)
- Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/ingredients/vitamin-e-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/ingredients/hexapeptide-9-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/ingredients/ceramide-building-complex-and-hexapeptide-9)
- Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/ingredients/cholesterol-and-hexapeptide-9)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/ingredients/phytosterol-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/ingredients/hexapeptide-9-and-squalene)
- Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/ingredients/hexapeptide-9-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/ingredients/salicylic-acid-and-hexapeptide-9)
- Keep them apart: [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-baking-soda)
- Keep them apart: [Bio-placenta peptides and baking soda](https://lovi.care/skincare/ingredients/bio-placenta-peptides-and-baking-soda)
- Keep them apart: [Collagen peptide and baking soda](https://lovi.care/skincare/ingredients/collagen-peptide-and-baking-soda)
- Keep them apart: [Copper peptide and baking soda](https://lovi.care/skincare/ingredients/copper-peptide-and-baking-soda)
- Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/ingredients/hexapeptide-and-baking-soda)
- Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/ingredients/bleach-and-hexapeptide-9)
- Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/ingredients/potassium-hydroxide-and-hexapeptide-9)
- Keep them apart: [Baking soda and palmitoyl pentapeptide-4](https://lovi.care/skincare/ingredients/baking-soda-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Baking soda and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/baking-soda-and-palmitoyl-tripeptide-1)
- Keep them apart: [Peptide-rich plasma and baking soda](https://lovi.care/skincare/ingredients/peptide-rich-plasma-and-baking-soda)
- Keep them apart: [Triple peptide blend and baking soda](https://lovi.care/skincare/ingredients/triple-peptide-blend-and-baking-soda)
- Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-9-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/ingredients/hexapeptide-9-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/ingredients/polyvinyl-alcohol-and-hexapeptide-9)
- Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/ingredients/copper-and-hexapeptide-9)
- Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-hexapeptide-9)
- Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/ingredients/magnesium-and-hexapeptide-9)
- Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/ingredients/zinc-and-hexapeptide-9)
- Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/ingredients/zinc-sulfate-and-hexapeptide-9)
- Keep them apart: [Vitamin C and baking soda](https://lovi.care/skincare/ingredients/vitamin-c-and-baking-soda)
- Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/ingredients/azelaic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/ingredients/hexapeptide-9-and-protease)
- Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/ingredients/superoxide-dismutase-and-hexapeptide-9)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/hexapeptide-9-and-baking-soda (this page)
- United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-9-and-baking-soda
- Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-baking-soda
- Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-9-and-baking-soda
- France: https://lovi.care/skincare/fr/ingredients/hexapeptide-9-and-baking-soda
- Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-9-and-baking-soda
- Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-9-and-baking-soda
- Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-9-and-baking-soda
- Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-9-and-baking-soda
- Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-9-and-baking-soda
- Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-9-and-baking-soda
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-9-and-baking-soda
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-9-and-baking-soda