# Copper and acetyl hexapeptide-3

Page: https://lovi.care/skincare/ingredients/copper-and-acetyl-hexapeptide-3

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Keep them apart

Use them on alternate nights, applying [copper peptides](https://lovi.care/skincare/ingredients/copper-peptide) on even days and [acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3) on odd days, to get the best results. Combining these two active ingredients can cause them to cancel each other out, meaning you will not see the firming and smoothing benefits you want. You can easily fix this by giving your skin more time between the two products.

- [All about copper](https://lovi.care/skincare/ingredients/copper)
- [All about acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3)

### [Copper](https://lovi.care/skincare/ingredients/copper) products

- [Minimalist Vitamin B5 10% Moisturizer](https://lovi.care/skincare/p/minimalist/vitamin-b5-10-moisturizer/for/mature-skin) — High fit — [$7.99 at Amazon](https://www.amazon.com/dp/B09Q3MWP2S?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

### [Acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3) products

- [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [$32.00 at Amazon](https://www.amazon.com/dp/B0C9DXGXZ3?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit — [$19.90 at Amazon](https://www.amazon.com/dp/B0BLHW7JZM?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Medik8 Liquid Peptides](https://lovi.care/skincare/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [$95.00 at Amazon](https://www.amazon.com/dp/B0DT1LYVZ6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [La Mer The Treatment Lotion](https://lovi.care/skincare/p/la-mer/the-treatment-lotion/for/mature-skin) — Superior fit — [$165.99 at Amazon](https://www.amazon.com/dp/B076ZQ7YVB?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit — [$68.45 at Amazon](https://www.amazon.com/dp/B0HQFQ4SML?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit — [$9.70 at Amazon](https://www.amazon.com/dp/B072JH13CD?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Good Molecules Super Peptide Serum](https://lovi.care/skincare/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [$12.00 at Amazon](https://www.amazon.com/dp/B091MTKS35?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [$109.00 at Amazon](https://www.amazon.com/dp/B09FG8TJDD?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [La Mer The Renewal Oil](https://lovi.care/skincare/p/la-mer/the-renewal-oil/for/mature-skin) — High fit — [$305.00 at Amazon](https://www.amazon.com/dp/B0163GAMI4?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/p/estee-lauder/micro-essence-treatment-lotion/for/oily-acne-prone-skin) — Superior fit — [$80.00 at Amazon](https://www.amazon.com/dp/B0BB44W3QP?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit
- [La Mer The Eye Concentrate](https://lovi.care/skincare/p/la-mer/the-eye-concentrate/for/mature-skin) — High fit — [$180.00 at Amazon](https://www.amazon.com/dp/B001P78JT6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use copper and acetyl hexapeptide-3 together?

Keep [copper](https://lovi.care/skincare/ingredients/copper) and [acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3) apart by using them in alternating routines, because combining them may cause oxidation or inactivation of the [copper complex](https://lovi.care/skincare/ingredients/complex). Acetyl hexapeptide-3 helps decrease skin roughness and improves wrinkles when used consistently.

[American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/) [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Which goes first, copper or acetyl hexapeptide-3?

Keep copper and acetyl hexapeptide-3 apart by using them in alternating routines to avoid potential oxidation or inactivation of the copper complex.

### Are copper and acetyl hexapeptide-3 good for sensitive skin?

Keep copper and acetyl hexapeptide-3 apart because they may react when combined in the same routine, though copper complexes are suitable for sensitive skin. Acetyl hexapeptide-3 helps reduce wrinkles when used twice daily.

[American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/) [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

## Research on copper and acetyl hexapeptide-3

- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-3 · Annals of Dermatology, 2019
- [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Copper · Journal of Cosmetic Dermatology, 2019
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013

## Other combinations

- Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/adapalene-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and granactive retinoid](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid)
- Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/pro-retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Retinal and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/retinal-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-retinoid-blend)
- Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/tretinoin-and-acetyl-hexapeptide-3)
- Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/vitamin-a-and-acetyl-hexapeptide-3)
- Work well together: [Liposome and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/liposome-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-microcapsule)
- Depends on the strength: [Vitamin C and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/vitamin-c-and-acetyl-hexapeptide-3)
- Keep them apart: [Vitamin C and copper](https://lovi.care/skincare/ingredients/vitamin-c-and-copper)
- Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-betaine)
- Work well together: [Glycerin and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/glycerin-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/niacinamide-and-acetyl-hexapeptide-3)
- Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/panthenol-and-acetyl-hexapeptide-3)
- Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/bakuchiol-and-acetyl-hexapeptide-3)
- Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/arginine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-gaba)
- Work well together: [Silk amino acids and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3)
- Work well together: [Taurine and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/taurine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-citric-acid)
- Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/glycolic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/lactic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3)
- Work well together: [Green tea and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/green-tea-and-acetyl-hexapeptide-3)
- Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/vitamin-e-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and beta-sitosterol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-cholesterol)
- Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-phytosphingosine)
- Work well together: [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-phytosterol)
- Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-squalene)
- Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/salicylic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-baking-soda)
- Keep them apart: [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-bleach)
- Keep them apart: [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide)
- Keep them apart: [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol)
- Keep them apart: [Bio-placenta peptides and copper](https://lovi.care/skincare/ingredients/bio-placenta-peptides-and-copper)
- Keep them apart: [Copper and collagen peptide](https://lovi.care/skincare/ingredients/copper-and-collagen-peptide)
- Keep them apart: [Copper and copper peptide](https://lovi.care/skincare/ingredients/copper-and-copper-peptide)
- Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/ingredients/hexapeptide-and-copper)
- Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/ingredients/copper-and-hexapeptide-9)
- Keep them apart: [Copper and palmitoyl pentapeptide-4](https://lovi.care/skincare/ingredients/copper-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Copper and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/copper-and-palmitoyl-tripeptide-1)
- Keep them apart: [Copper and peptide-rich plasma](https://lovi.care/skincare/ingredients/copper-and-peptide-rich-plasma)
- Keep them apart: [Copper and triple peptide blend](https://lovi.care/skincare/ingredients/copper-and-triple-peptide-blend)
- Keep them apart: [Magnesium and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/magnesium-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-zinc)
- Keep them apart: [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3)
- Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/azelaic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-protease)
- Keep them apart: [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/copper-and-acetyl-hexapeptide-3 (this page)
- United Kingdom: https://lovi.care/skincare/uk/ingredients/copper-and-acetyl-hexapeptide-3
- Ireland: https://lovi.care/skincare/ie/ingredients/copper-and-acetyl-hexapeptide-3
- Germany: https://lovi.care/skincare/de/ingredients/copper-and-acetyl-hexapeptide-3
- France: https://lovi.care/skincare/fr/ingredients/copper-and-acetyl-hexapeptide-3
- Italy: https://lovi.care/skincare/it/ingredients/copper-and-acetyl-hexapeptide-3
- Netherlands: https://lovi.care/skincare/nl/ingredients/copper-and-acetyl-hexapeptide-3
- Spain: https://lovi.care/skincare/es/ingredients/copper-and-acetyl-hexapeptide-3
- Canada: https://lovi.care/skincare/ca/ingredients/copper-and-acetyl-hexapeptide-3
- Australia: https://lovi.care/skincare/au/ingredients/copper-and-acetyl-hexapeptide-3
- Singapore: https://lovi.care/skincare/sg/ingredients/copper-and-acetyl-hexapeptide-3
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/copper-and-acetyl-hexapeptide-3
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/copper-and-acetyl-hexapeptide-3