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Collagen peptide and protease

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Collagen peptide and protease: keep them apart

Keep them apart

Use them at different times of day, applying the protease first and the peptide second, because they cancel each other out. The protease breaks down the peptide, stopping it from firming the skin. You can separate them by using one in the morning and the other at night.

Collagen peptide products

Protease products

Questions and answers

Can you use collagen peptide and protease together?

No, you should keep collagen peptide and protease apart because proteases degrade peptide bonds and render the active ingredients inactive. Avoid using them together in the same routine.

Which goes first, collagen peptide or protease?

Keep collagen peptide and protease apart because the protease degrades the peptide bonds and renders the active ingredient inactive.

Are collagen peptide and protease good for sensitive skin?

Collagen peptide and protease should be kept apart in your routine because the protease degrades the peptide bonds and renders the active ingredients inactive. While collagen peptides generally help support skin health, you should avoid combining enzymatic ingredients with peptides to ensure they remain effective.

Research on collagen peptide and protease

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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