# Adapalene and acetyl hexapeptide-3 Page: https://lovi.care/skincare/ingredients/adapalene-and-acetyl-hexapeptide-3 The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States. Keep them apart Use them at different times of day by applying [acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3) in the morning and [adapalene](https://lovi.care/skincare/ingredients/adapalene) at night, because strong retinoids should not be mixed with peptides in the same routine. Using them together can overwhelm your skin and cause extra redness or irritation, but you can easily avoid this by leaving more time between the two or switching to a gentler formula. - [All about adapalene](https://lovi.care/skincare/ingredients/adapalene) - [All about acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3) ### [Adapalene](https://lovi.care/skincare/ingredients/adapalene) products - [Differin Gel](https://lovi.care/skincare/p/differin/gel/for/oily-acne-prone-skin) — High fit — [$36.99 at Amazon](https://www.amazon.com/dp/B07H5WQQL7?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) - [Galderma Epiduo Gel](https://lovi.care/skincare/p/galderma/epiduo-gel/for/acne-prone-skin) — High fit — [$34.97 at Amazon](https://www.amazon.com/dp/B0GSSCQ6J2?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) - [La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment](https://lovi.care/skincare/p/la-roche-posay/effaclar-adapalene-gel-0-1-acne-treatment/for/oily-skin) — Superior fit — [$39.99 at Amazon](https://www.amazon.com/dp/B07SQFQFXX?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) ### [Acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3) products - [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [$32.00 at Amazon](https://www.amazon.com/dp/B0C9DXGXZ3?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) - [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit — [$19.90 at Amazon](https://www.amazon.com/dp/B0BLHW7JZM?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) - [Medik8 Liquid Peptides](https://lovi.care/skincare/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [$95.00 at Amazon](https://www.amazon.com/dp/B0DT1LYVZ6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) - [La Mer The Treatment Lotion](https://lovi.care/skincare/p/la-mer/the-treatment-lotion/for/mature-skin) — Superior fit — [$165.99 at Amazon](https://www.amazon.com/dp/B076ZQ7YVB?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) - [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit — [$68.45 at Amazon](https://www.amazon.com/dp/B0HQFQ4SML?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) - [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit — [$9.70 at Amazon](https://www.amazon.com/dp/B072JH13CD?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) - [Good Molecules Super Peptide Serum](https://lovi.care/skincare/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [$12.00 at Amazon](https://www.amazon.com/dp/B091MTKS35?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) - [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [$109.00 at Amazon](https://www.amazon.com/dp/B09FG8TJDD?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) - [La Mer The Renewal Oil](https://lovi.care/skincare/p/la-mer/the-renewal-oil/for/mature-skin) — High fit — [$305.00 at Amazon](https://www.amazon.com/dp/B0163GAMI4?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) - [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/p/estee-lauder/micro-essence-treatment-lotion/for/oily-acne-prone-skin) — Superior fit — [$80.00 at Amazon](https://www.amazon.com/dp/B0BB44W3QP?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) - [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit - [La Mer The Eye Concentrate](https://lovi.care/skincare/p/la-mer/the-eye-concentrate/for/mature-skin) — High fit — [$180.00 at Amazon](https://www.amazon.com/dp/B001P78JT6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use adapalene and acetyl hexapeptide-3 together? Keep [adapalene](https://lovi.care/skincare/ingredients/adapalene) and [acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3) apart because combining them may increase skin irritation. Instead, alternate their usage by applying adapalene in the PM and peptides in the AM. ### Which goes first, adapalene or acetyl hexapeptide-3? Keep adapalene and acetyl hexapeptide-3 apart because combined stimulation may increase irritation. Alternate usage by applying your retinoid in the PM and peptides in the AM. ### Are adapalene and acetyl hexapeptide-3 good for sensitive skin? Keep adapalene and acetyl hexapeptide-3 apart because combined stimulation may increase irritation, making them unsuitable to use together on sensitive skin. Instead, alternate usage by applying the retinoid in the PM and peptides in the AM. ## Research on adapalene and acetyl hexapeptide-3 - [Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison](https://pubmed.ncbi.nlm.nih.gov/29549588/) Adapalene · American Journal of Clinical Dermatology, 2018 - [Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug](https://pubmed.ncbi.nlm.nih.gov/34674160/) Adapalene · American Journal of Clinical Dermatology, 2022 - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013 - [A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/34251536/) Adapalene · Archives of Dermatological Research, 2022 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-3 · Annals of Dermatology, 2019 - [Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials](https://pubmed.ncbi.nlm.nih.gov/37656094/) Adapalene · Journal of the American Academy of Dermatology, 2023 - [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017 - [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013 ## Other combinations - Keep them apart: [Acetyl hexapeptide-3 and granactive retinoid](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid) - Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate) - Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/pro-retinol-and-acetyl-hexapeptide-3) - Keep them apart: [Retinal and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/retinal-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-retinoid-blend) - Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/retinol-and-acetyl-hexapeptide-3) - Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/tretinoin-and-acetyl-hexapeptide-3) - Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/vitamin-a-and-acetyl-hexapeptide-3) - Keep them apart: [Adapalene and bio-placenta peptides](https://lovi.care/skincare/ingredients/adapalene-and-bio-placenta-peptides) - Keep them apart: [Adapalene and collagen peptide](https://lovi.care/skincare/ingredients/adapalene-and-collagen-peptide) - Keep them apart: [Adapalene and copper peptide](https://lovi.care/skincare/ingredients/adapalene-and-copper-peptide) - Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/ingredients/adapalene-and-hexapeptide) - Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/ingredients/adapalene-and-hexapeptide-9) - Keep them apart: [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/ingredients/adapalene-and-palmitoyl-pentapeptide-4) - Keep them apart: [Adapalene and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/adapalene-and-palmitoyl-tripeptide-1) - Keep them apart: [Adapalene and peptide-rich plasma](https://lovi.care/skincare/ingredients/adapalene-and-peptide-rich-plasma) - Keep them apart: [Adapalene and triple peptide blend](https://lovi.care/skincare/ingredients/adapalene-and-triple-peptide-blend) - Work well together: [Liposome and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/liposome-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-microcapsule) - Depends on the strength: [Vitamin C and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/vitamin-c-and-acetyl-hexapeptide-3) - Depends on the strength: [Adapalene and niacinamide](https://lovi.care/skincare/ingredients/adapalene-and-niacinamide) - Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-betaine) - Work well together: [Glycerin and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/glycerin-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/niacinamide-and-acetyl-hexapeptide-3) - Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/panthenol-and-acetyl-hexapeptide-3) - Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/bakuchiol-and-acetyl-hexapeptide-3) - Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/arginine-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-gaba) - Work well together: [Silk amino acids and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3) - Work well together: [Taurine and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/taurine-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-citric-acid) - Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/glycolic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/lactic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-mandelic-acid) - Work well together: [Coenzyme Q10 and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3) - Work well together: [Green tea and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/green-tea-and-acetyl-hexapeptide-3) - Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/vitamin-e-and-acetyl-hexapeptide-3) - Keep them apart: [Adapalene and aha blend glycolic and citric acids](https://lovi.care/skincare/ingredients/adapalene-and-aha-blend-glycolic-and-citric-acids) - Keep them apart: [Adapalene and citric acid](https://lovi.care/skincare/ingredients/adapalene-and-citric-acid) - Keep them apart: [Adapalene and glycolic acid](https://lovi.care/skincare/ingredients/adapalene-and-glycolic-acid) - Keep them apart: [Adapalene and lactic acid](https://lovi.care/skincare/ingredients/adapalene-and-lactic-acid) - Keep them apart: [Adapalene and mandelic acid](https://lovi.care/skincare/ingredients/adapalene-and-mandelic-acid) - Work well together: [Acetyl hexapeptide-3 and beta-sitosterol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol) - Work well together: [Ceramide-building complex and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-cholesterol) - Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-phytosphingosine) - Work well together: [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-phytosterol) - Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-squalene) - Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/salicylic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Adapalene and salicylic acid](https://lovi.care/skincare/ingredients/adapalene-and-salicylic-acid) - Keep them apart: [Adapalene and vitamin C](https://lovi.care/skincare/ingredients/adapalene-and-vitamin-c) - Keep them apart: [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-baking-soda) - Keep them apart: [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-bleach) - Keep them apart: [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide) - Keep them apart: [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol) - Keep them apart: [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol) - Keep them apart: [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol) - Keep them apart: [Copper and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/copper-and-acetyl-hexapeptide-3) - Keep them apart: [Adapalene and benzoyl peroxide](https://lovi.care/skincare/ingredients/adapalene-and-benzoyl-peroxide) - Keep them apart: [Magnesium and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/magnesium-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-zinc) - Keep them apart: [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3) - Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/azelaic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-protease) - Keep them apart: [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/adapalene-and-acetyl-hexapeptide-3 (this page) - United Kingdom: https://lovi.care/skincare/uk/ingredients/adapalene-and-acetyl-hexapeptide-3 - Ireland: https://lovi.care/skincare/ie/ingredients/adapalene-and-acetyl-hexapeptide-3 - Germany: https://lovi.care/skincare/de/ingredients/adapalene-and-acetyl-hexapeptide-3 - France: https://lovi.care/skincare/fr/ingredients/adapalene-and-acetyl-hexapeptide-3 - Italy: https://lovi.care/skincare/it/ingredients/adapalene-and-acetyl-hexapeptide-3 - Netherlands: https://lovi.care/skincare/nl/ingredients/adapalene-and-acetyl-hexapeptide-3 - Spain: https://lovi.care/skincare/es/ingredients/adapalene-and-acetyl-hexapeptide-3 - Canada: https://lovi.care/skincare/ca/ingredients/adapalene-and-acetyl-hexapeptide-3 - Australia: https://lovi.care/skincare/au/ingredients/adapalene-and-acetyl-hexapeptide-3 - Singapore: https://lovi.care/skincare/sg/ingredients/adapalene-and-acetyl-hexapeptide-3 - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/adapalene-and-acetyl-hexapeptide-3 - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/adapalene-and-acetyl-hexapeptide-3