# Acetyl hexapeptide-3 and superoxide dismutase

Page: https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Keep them apart

Use them at different times of day, applying the peptide first and the enzyme later, because they cancel each other out. [Superoxide dismutase](https://lovi.care/skincare/ingredients/superoxide-dismutase) can break down [acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3), which stops the peptide from smoothing fine lines and firming the skin. The shopper can separate them by morning and night to get the best results from both products.

- [All about acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3)
- [All about superoxide dismutase](https://lovi.care/skincare/ingredients/superoxide-dismutase)

### [Acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3) products

- [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [$32.00 at Amazon](https://www.amazon.com/dp/B0C9DXGXZ3?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit — [$19.90 at Amazon](https://www.amazon.com/dp/B0BLHW7JZM?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Medik8 Liquid Peptides](https://lovi.care/skincare/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [$95.00 at Amazon](https://www.amazon.com/dp/B0DT1LYVZ6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [La Mer The Treatment Lotion](https://lovi.care/skincare/p/la-mer/the-treatment-lotion/for/mature-skin) — Superior fit — [$165.99 at Amazon](https://www.amazon.com/dp/B076ZQ7YVB?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit — [$68.45 at Amazon](https://www.amazon.com/dp/B0HQFQ4SML?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit — [$9.70 at Amazon](https://www.amazon.com/dp/B072JH13CD?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Good Molecules Super Peptide Serum](https://lovi.care/skincare/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [$12.00 at Amazon](https://www.amazon.com/dp/B091MTKS35?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [$109.00 at Amazon](https://www.amazon.com/dp/B09FG8TJDD?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [La Mer The Renewal Oil](https://lovi.care/skincare/p/la-mer/the-renewal-oil/for/mature-skin) — High fit — [$305.00 at Amazon](https://www.amazon.com/dp/B0163GAMI4?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/p/estee-lauder/micro-essence-treatment-lotion/for/oily-acne-prone-skin) — Superior fit — [$80.00 at Amazon](https://www.amazon.com/dp/B0BB44W3QP?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit
- [La Mer The Eye Concentrate](https://lovi.care/skincare/p/la-mer/the-eye-concentrate/for/mature-skin) — High fit — [$180.00 at Amazon](https://www.amazon.com/dp/B001P78JT6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

### [Superoxide dismutase](https://lovi.care/skincare/ingredients/superoxide-dismutase) products

- [iS Clinical Reparative Moisture Emulsion](https://lovi.care/skincare/p/is-clinical/reparative-moisture-emulsion/for/dry-skin) — High fit
- [U Beauty Resurfacing Compound](https://lovi.care/skincare/p/u-beauty/resurfacing-compound/for/dark-spots) — High fit — [$148.00 at Amazon](https://www.amazon.com/dp/B089B9MZ1H?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Skinbetter Science Alto Advanced Defense and Repair Serum](https://lovi.care/skincare/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/dry-sensitive-skin) — High fit
- [Skin Better Science Alto Advanced Defense and Repair Serum](https://lovi.care/skincare/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin) — High fit
- [Skinbetter Science Alto Defense Serum](https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/dark-spots) — High fit
- [NIOD Modulating Glucosides](https://lovi.care/skincare/p/niod/modulating-glucosides/for/mature-skin) — High fit
- [Charlotte Tilbury Magic Eye Rescue](https://lovi.care/skincare/p/charlotte-tilbury/magic-eye-rescue/for/dark-spots) — Average fit — [$65.00 at Amazon](https://www.amazon.com/dp/B0FGG3LFKK?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — [$53.00 at Amazon](https://www.amazon.com/dp/B00EEGEI7C?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
- [Image Skincare Vital C Hydrating Enzyme Masque](https://lovi.care/skincare/p/image-skincare/vital-c-hydrating-enzyme-masque/for/mature-skin) — High fit
- [NIOD Superoxide Dismutase Saccharide Mist](https://lovi.care/skincare/p/niod/superoxide-dismutase-saccharide-mist/for/dry-sensitive-skin) — Average fit
- [Dr. Dennis Gross C + Collagen Biocellulose Brightening Treatment Mask](https://lovi.care/skincare/p/dr-dennis-gross/c-collagen-biocellulose-brightening-treatment-mask/for/mature-skin) — High fit — [$46.00 at Amazon](https://www.amazon.com/dp/B0BS4FVQZ4?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use acetyl hexapeptide-3 and superoxide dismutase together?

Keep [acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3) and [superoxide dismutase](https://lovi.care/skincare/ingredients/superoxide-dismutase) apart because enzymes degrade peptides and render them inactive.

### Which goes first, acetyl hexapeptide-3 or superoxide dismutase?

Keep acetyl hexapeptide-3 and superoxide dismutase apart because enzymes or [proteases](https://lovi.care/skincare/ingredients/protease) can degrade peptide bonds and render the active inactive.

### Are acetyl hexapeptide-3 and superoxide dismutase good for sensitive skin?

Keep acetyl hexapeptide-3 and superoxide dismutase apart in your routine because enzymes degrade peptides and render them inactive.

## Research on acetyl hexapeptide-3 and superoxide dismutase

- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-3 · Annals of Dermatology, 2019
- [Topical application of superoxide dismutase mediated by HIV-TAT peptide attenuates UVB-induced damages in human skin](https://pubmed.ncbi.nlm.nih.gov/27460952/) Superoxide dismutase · European Journal of Pharmaceutics and Biopharmaceutics, 2016
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017
- [Use of the synthetic superoxide dismutase/catalase mimetic EUK-134 to compensate for seasonal antioxidant deficiency by reducing pre-existing lipid peroxides at the human skin surface](https://pubmed.ncbi.nlm.nih.gov/18492138/) Superoxide dismutase · International Journal of Cosmetic Science, 2004
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013

## Other combinations

- Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/adapalene-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and granactive retinoid](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid)
- Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/pro-retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Retinal and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/retinal-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-retinoid-blend)
- Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/tretinoin-and-acetyl-hexapeptide-3)
- Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/vitamin-a-and-acetyl-hexapeptide-3)
- Work well together: [Liposome and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/liposome-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-microcapsule)
- Depends on the strength: [Vitamin C and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/vitamin-c-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-betaine)
- Work well together: [Glycerin and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/glycerin-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/niacinamide-and-acetyl-hexapeptide-3)
- Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/panthenol-and-acetyl-hexapeptide-3)
- Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/bakuchiol-and-acetyl-hexapeptide-3)
- Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/arginine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-gaba)
- Work well together: [Silk amino acids and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3)
- Work well together: [Taurine and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/taurine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-citric-acid)
- Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/glycolic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/lactic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3)
- Work well together: [Green tea and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/green-tea-and-acetyl-hexapeptide-3)
- Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/vitamin-e-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and beta-sitosterol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-cholesterol)
- Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-phytosphingosine)
- Work well together: [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-phytosterol)
- Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-squalene)
- Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/salicylic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-baking-soda)
- Keep them apart: [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-bleach)
- Keep them apart: [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide)
- Keep them apart: [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol)
- Keep them apart: [Copper and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/copper-and-acetyl-hexapeptide-3)
- Keep them apart: [Magnesium and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/magnesium-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-zinc)
- Keep them apart: [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3)
- Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ingredients/azelaic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-protease)
- Keep them apart: [Bio-placenta peptides and superoxide dismutase](https://lovi.care/skincare/ingredients/bio-placenta-peptides-and-superoxide-dismutase)
- Keep them apart: [Superoxide dismutase and collagen peptide](https://lovi.care/skincare/ingredients/superoxide-dismutase-and-collagen-peptide)
- Keep them apart: [Superoxide dismutase and copper peptide](https://lovi.care/skincare/ingredients/superoxide-dismutase-and-copper-peptide)
- Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/ingredients/hexapeptide-and-superoxide-dismutase)
- Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/ingredients/superoxide-dismutase-and-hexapeptide-9)
- Keep them apart: [Superoxide dismutase and palmitoyl pentapeptide-4](https://lovi.care/skincare/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Superoxide dismutase and palmitoyl tripeptide-1](https://lovi.care/skincare/ingredients/superoxide-dismutase-and-palmitoyl-tripeptide-1)
- Keep them apart: [Superoxide dismutase and peptide-rich plasma](https://lovi.care/skincare/ingredients/superoxide-dismutase-and-peptide-rich-plasma)
- Keep them apart: [Superoxide dismutase and triple peptide blend](https://lovi.care/skincare/ingredients/superoxide-dismutase-and-triple-peptide-blend)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase (this page)
- United Kingdom: https://lovi.care/skincare/uk/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase
- Ireland: https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase
- Germany: https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase
- France: https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase
- Italy: https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase
- Netherlands: https://lovi.care/skincare/nl/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase
- Spain: https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase
- Canada: https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase
- Australia: https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase
- Singapore: https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase