# VT Cosmetics PDRN Essence 100 for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Brand: [VT Cosmetics](https://lovi.care/skincare/ie/brands/vt-cosmetics)
Category: [Serums and treatments](https://lovi.care/skincare/ie/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for sensitive skin.

## Why this fit

- Offers excellent skin regeneration for your normal skin, as PDRN Polydeoxyribonucleotide and Sodium Hyaluronate improve elasticity and hydration, while niacinamide and panthenol soothe redness and irritation.
- The presence of glycerin and allantoin further supports barrier repair and hydration, making it a well-rounded choice for maintaining comfortable skin.
- The formula is safe for your sensitive skin, with no harsh or prohibited ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/oily-acne-prone-skin): High

## Key ingredients

Pdrn Polydeoxyribonucleotide, Sodium Hyaluronate, Niacinamide, Adenosine

## What the research says

- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## What reviewers say

Based on a very large amount of data, users with dry, sensitive, and combination skin highly praise this essence for its ability to deliver a glass skin finish and deep hydration without irritation. It is widely celebrated for restoring compromised barriers and plumping fine lines. A minority of users with oily skin find the texture too heavy or tacky.

- Liked: Hydration and glow (mostly mentioned)
- Liked: Soothing and repair (often mentioned)
- Liked: Fragrance-free (sometimes noted)
- Liked: Good texture (sometimes noted)
- Disliked: Sticky finish (sometimes noted)
- Liked: Nice packaging (rarely noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Expensive price (rarely noted)
- Disliked: Pump design (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes VT COSMETICS PDRN Essence 100 a great fit for sensitive skin?

VT COSMETICS PDRN Essence 100 is a great fit for sensitive skin because it is free of harsh ingredients and uses soothing agents like niacinamide and panthenol to calm redness. It also contains sodium hyaluronate, glycerin, and allantoin to deeply hydrate and repair your skin barrier, helping to keep it comfortable.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Which ingredients make this treatment a good fit for sensitive skin?

This treatment is a great fit for sensitive skin because it contains panthenol and niacinamide to calm redness and irritation, along with sodium hyaluronate and glycerin to boost hydration. These ingredients work together to support barrier repair while keeping the formula safe and gentle.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does PDRN do for sensitive skin?

PDRN helps calm sensitive skin by reducing redness and soothing irritation while supporting tissue repair. It is unlikely to cause irritation, making it generally well-tolerated for delicate skin types.
Sources: [Regenerative Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32757710/), [Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### Where does this treatment go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after your toner and before your moisturizer. Placing treatments in the evening helps keep your routine simple and avoids extra irritation around sun exposure.

### Can I use this treatment with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment after your soothing toner and before your moisturizer in the evening, as this formula is safe and free of harsh ingredients that could cause irritation. Using a gentle, barrier-repairing routine helps keep your sensitive skin comfortable and calm.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this treatment?

This treatment is a great fit for your sensitive skin and is used in the evening routine. The gentle formula uses soothing ingredients like niacinamide and panthenol to help keep your skin calm and comfortable.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Can this treatment clog pores, cause breakouts or purging for sensitive skin?

VT COSMETICS PDRN Essence 100 is unlikely to cause breakouts for sensitive skin, as it contains no harsh ingredients and has a very low rate of reported breakouts. Reviewers mention only occasional breakouts, and the gentle formula helps keep skin calm and comfortable.

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ie/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €185.00 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/ie/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €29.07 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ie/p/cosrx/the-vitamin-c-23-serum/for/sensitive-skin) — High fit — €22.51 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ie/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €56.86 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/ie/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €21.81 at Amazon
- Moisturizer with Sun Protection: [Clinique Mineral Sunscreen Fluid for Face SPF 50](https://lovi.care/skincare/ie/p/clinique/broad-spectrum-spf-50-mineral-sunscreen-fluid-for-face/for/sensitive-skin) — Superior fit — €39.35 at Amazon

## Where to buy

- Amazon.ie: €29.00 (https://www.amazon.ie/dp/B0CRKPZ9PQ?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- Notino: €39.90 (https://www.notino.ie/vt-cosmetics/pdrn-100-essence-rejuvinating-face-essence-with-moisturising-effect/p-16345771/)
- Lookfantastic: €40.00 (https://www.lookfantastic.ie/p/vt-cosmetics-pdrn-essence-100/17620559/)
Prices checked 16 Oct – 6 Nov 2026.

## Ingredients

Water, Pdrn Polydeoxyribonucleotide, Sodium Hyaluronate, Glycerin, Butylene Glycol, Niacinamide, Panthenol, Allantoin, Adenosine, Betaine, Phenoxyethanol, Ethylhexylglycerin, Carbomer, Triethanolamine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin (this page)
- Germany: https://lovi.care/skincare/de/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin