# VT Cosmetics PDRN Essence 100 for oily skin

**Lovi Fit: Average fit for oily skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Brand: [VT Cosmetics](https://lovi.care/skincare/ie/brands/vt-cosmetics)
Category: [Serums and treatments](https://lovi.care/skincare/ie/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your oily skin, with niacinamide helping to regulate sebum and sodium hyaluronate providing hydration, though it does not directly address concerns about oily shine.
- The inclusion of PDRN and panthenol supports skin regeneration and barrier resilience, which are generally beneficial for maintaining healthy skin.
- The product is safe for your oily skin, as it contains soothing ingredients like sodium hyaluronate and glycerin and lacks harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/oily-skin): Average (this page)
- [Dry skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/oily-acne-prone-skin): High

## Key ingredients

Pdrn Polydeoxyribonucleotide, Sodium Hyaluronate, Niacinamide, Adenosine

## What the research says

- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## Why other serums fit oily skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on a very large amount of data, users with dry, sensitive, and combination skin highly praise this essence for its ability to deliver a glass skin finish and deep hydration without irritation. It is widely celebrated for restoring compromised barriers and plumping fine lines. A minority of users with oily skin find the texture too heavy or tacky.

- Liked: Hydration and glow (mostly mentioned)
- Liked: Soothing and repair (often mentioned)
- Liked: Fragrance-free (sometimes noted)
- Liked: Good texture (sometimes noted)
- Disliked: Sticky finish (sometimes noted)
- Liked: Nice packaging (rarely noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Expensive price (rarely noted)
- Disliked: Pump design (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does VT PDRN Essence 100 work for oily skin?

This essence works well enough for oily skin by offering moderate hydration and barrier support, though it does not directly target oily shine. To best manage oily skin, a treatment of this type needs ingredients like niacinamide and zinc PCA to control excess oil and large pores while keeping the skin balanced.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this treatment a good fit for oily skin?

Niacinamide helps regulate sebum, while sodium hyaluronate and glycerin provide comfortable hydration for your oily skin. Treatments of this type that fit oily skin best need ingredients like zinc pca and ferulic acid to manage oily shine and enlarged pores.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does PDRN do for oily skin?

PDRN helps calm and repair oily skin by supporting skin cell growth and collagen production. This ingredient is unlikely to clog pores while working to improve the overall texture and healing of your skin.

### What does Hyaluronic Acid do for oily skin?

Hyaluronic acid helps oily skin by reducing extra oil and sebum production without causing irritation. Clinical studies show it successfully balances oil levels while keeping the skin comfortable.
Sources: [The Journal of Investigative Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28163068/)

### Where does this treatment go in a skincare routine for oily skin?

This treatment goes in the evening routine for your oily skin, applied after cleansing and before moisturizing. Oily skin works best with products that provide lightweight hydration and help control shine.

### Can I use this treatment with retinol, and in what order?

You can use this treatment with retinol, applying the treatment before your moisturizer in your evening routine. This product is unlikely to cause irritation on oily skin, but an oily skin routine also needs lightweight, oil-balancing ingredients like niacinamide to help manage shine.

### How often should I use this treatment?

You can use this treatment in your evening routine. Oily skin works best with products that help control extra oil while keeping the skin hydrated.

### Can this treatment clog pores, cause breakouts or purging for oily skin?

This treatment is unlikely to cause breakouts for oily skin, as it contains soothing ingredients like sodium hyaluronate and glycerin without harsh substances, though reviews show a low chance of causing breakouts and a moderate chance of a sticky finish. Oily skin prone to clogged pores needs lightweight, oil-free hydration and pore-clearing ingredients like salicylic acid to keep skin clear.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/ie/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-skin) — Superior fit — €14.94 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/ie/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/oily-skin) — Superior fit — €52.57 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ie/p/skinceuticals/c-e-ferulic/for/oily-skin) — High fit — €185.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ie/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — €21.45 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/ie/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — €19.99 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ie/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-skin) — Superior fit — €16.50 at Amazon

## Where to buy

- Amazon.ie: €29.00 (https://www.amazon.ie/dp/B0CRKPZ9PQ?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- Notino: €39.90 (https://www.notino.ie/vt-cosmetics/pdrn-100-essence-rejuvinating-face-essence-with-moisturising-effect/p-16345771/)
- Lookfantastic: €40.00 (https://www.lookfantastic.ie/p/vt-cosmetics-pdrn-essence-100/17620559/)
Prices checked 16 Oct – 6 Nov 2026.

## Ingredients

Water, Pdrn Polydeoxyribonucleotide, Sodium Hyaluronate, Glycerin, Butylene Glycol, Niacinamide, Panthenol, Allantoin, Adenosine, Betaine, Phenoxyethanol, Ethylhexylglycerin, Carbomer, Triethanolamine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/vt-cosmetics/pdrn-essence-100/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/vt-cosmetics/pdrn-essence-100/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/oily-skin (this page)
- Germany: https://lovi.care/skincare/de/p/vt-cosmetics/pdrn-essence-100/for/oily-skin
- France: https://lovi.care/skincare/fr/p/vt-cosmetics/pdrn-essence-100/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/vt-cosmetics/pdrn-essence-100/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/vt-cosmetics/pdrn-essence-100/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/vt-cosmetics/pdrn-essence-100/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/vt-cosmetics/pdrn-essence-100/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/vt-cosmetics/pdrn-essence-100/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/vt-cosmetics/pdrn-essence-100/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/vt-cosmetics/pdrn-essence-100/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/vt-cosmetics/pdrn-essence-100/for/oily-skin