# Skinbetter Science Alto Defense Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ie/p/skinbetter-science/alto-defense-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Brand: [Skinbetter Science](https://lovi.care/skincare/ie/brands/skinbetter-science)
Category: [Serums and treatments](https://lovi.care/skincare/ie/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate hydration and antioxidant protection for your normal skin, with ingredients like Hydrolyzed Sodium Hyaluronate and Glycerin providing humectant action, but lacks specialized anti-aging ingredients to directly address wrinkles and fine lines.
- The presence of antioxidants such as tetrahexyldecyl ascorbate and ergothioneine offers general skincare benefits that you would notice, though they are not targeted for your primary concern.
- The product is safe for your normal skin, as it contains no harsh ingredients that would cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ie/p/skinbetter-science/alto-defense-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ie/p/skinbetter-science/alto-defense-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ie/p/skinbetter-science/alto-defense-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ie/p/skinbetter-science/alto-defense-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ie/p/skinbetter-science/alto-defense-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ie/p/skinbetter-science/alto-defense-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ie/p/skinbetter-science/alto-defense-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ie/p/skinbetter-science/alto-defense-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ie/p/skinbetter-science/alto-defense-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Vitis Vinifera Seed Extract Grape Seed Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Curcuma Longa Root Extract, Superoxide Dismutase, Tetrahexyldecyl Ascorbate

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Profhilo treatment led to significant improvements in superficial skin hydration and transepidermal water loss over time in Chinese females, while demonstrating good product tolerability. ([Aesthetic Plastic Surgery, 2026](https://pubmed.ncbi.nlm.nih.gov/40921777/))
- Topical application of a water-in-oil emulsion containing 2% Muscat hamburg grape seed extract significantly improved melanin, elasticity, and sebum content compared to a placebo in human volunteers over 8 weeks, with no reported skin hypersensitivity. ([International Journal of Cosmetic Science, 2015](https://pubmed.ncbi.nlm.nih.gov/25402429/))
- Topical CE Ferulic plus resveratrol BE serum following ablative fractional CO2 laser treatment reduced erythema index (308.9 vs. 325.3), shortened complete scabbing detachment time (6.0 vs. 6.5 days), decreased melanin index (-7.4% vs. +0.2%), and improved skin hydration compared to normal saline in 51 Chinese patients. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38828801/))
- Resveratrol cream improved skin hydration and tightening compared to cream without resveratrol in a group of probands. ([Acta Biochimica Polonica, 2019](https://pubmed.ncbi.nlm.nih.gov/31518087/))
- Topical treatment with a combination of pyridine-2, 4-dicarboxylic acid diethyl ester and resveratrol significantly increased hair density in 79 Caucasian female subjects starting from 1.5 months compared to baseline. ([International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31960447/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties. ([Skin Pharmacology and Physiology, 2023](https://pubmed.ncbi.nlm.nih.gov/38008088/))
- Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models. ([Drug Discovery Today, 2017](https://pubmed.ncbi.nlm.nih.gov/28711364/))
- A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation. ([Saudi Pharmaceutical Journal, 2024](https://pubmed.ncbi.nlm.nih.gov/38178851/))
- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls. ([International Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/18492138/))
- Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable. ([European Journal of Pharmaceutics and Biopharmaceutics, 2007](https://pubmed.ncbi.nlm.nih.gov/17196809/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))

## Why other serums fit mature skin better

- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))

## What reviewers say

Most users report a more luminous and even complexion without irritation. A few users note the high price point, small packaging, and occasional lack of visible results.

- Liked: Improves skin texture (often mentioned)
- Liked: Reduces skin redness (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Gentle and non-irritating (sometimes noted)
- Liked: Hydrates the skin (sometimes noted)
- Disliked: No visible results (rarely noted)
- Disliked: Small bottle size (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Alto Defense Serum work for mature skin?

Skinbetter Science Alto Defense Serum is an average fit for mature skin because it offers moderate hydration and antioxidant protection, but lacks specialized ingredients to directly address wrinkles and fine lines. A product of this type needs high concentrations of potent antioxidants, peptides, and skin-repairing ingredients to improve elasticity, retain moisture, and smooth out lines on mature skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

This serum fits mature skin reasonably well through hydrating agents like hydrolyzed sodium hyaluronate and glycerin, alongside antioxidants such as tetrahexyldecyl ascorbate and ergothioneine. However, a product for this skin type needs specialized anti-aging ingredients, potent antioxidants, and skin-repairing peptides to smooth fine lines and improve elasticity.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Grape Seed Extract do for mature skin?

Grape seed extract helps smooth out wrinkles and rough patches while boosting skin firmness and hydration. It is unlikely to cause irritation and may improve skin elasticity and reduce excess oil.
Sources: [Pakistan Journal of Pharmaceutical Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34799340/), [International Journal of Cosmetic Science, 2015](https://pubmed.ncbi.nlm.nih.gov/25402429/)

### What does Licorice Root Extract do for mature skin?

Licorice root extract helps calm mature skin and evens out skin tone by reducing dark spots and protecting against daily stress. It works to brighten the complexion while soothing irritation and supporting a smooth, healthy appearance.
Sources: [Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/), [Anais Brasileiros de Dermatologia, 2010](https://pubmed.ncbi.nlm.nih.gov/21152784/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, following general skincare guidance for active treatments. Mature skin routines need targeted anti-aging ingredients like peptides and retinoids to effectively address fine lines and wrinkles.

### Can I use it with retinol, and in what order?

You can use this treatment alongside a retinol, applying the treatment first and following with your retinol and moisturizer. A product for mature skin also needs specialized anti-aging ingredients like peptides or retinoids to directly smooth fine lines and wrinkles.

### How often should I use this serum?

This serum works well in your evening routine, and some people can also use it in the morning or twice a day. It offers moderate hydration and antioxidant protection, but mature skin needs targeted ingredients like retinoids and peptides to directly address wrinkles and fine lines.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can it clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it contains no harsh or heavy ingredients that typically cause irritation. However, because it is only an average fit for your skin, a product of this type needs specialized anti-aging ingredients like retinol or peptides and richer moisturizers to effectively smooth fine lines and deeply hydrate mature skin.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ie/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €185.00 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/ie/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €31.40 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/ie/p/augustinus-bader/the-serum/for/mature-skin) — High fit — €385.99 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ie/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €56.86 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ie/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.28 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/ie/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €50.82 at Amazon

## Where to buy

No store in Ireland has a checked price for this product, so the page shows none.

## Ingredients

Water, Butylene Glycol, Propanediol, Ethylhexyl Olivate, Cetearyl Alcohol, Chlorogenic Acids, Hydrolyzed Sodium Hyaluronate, Lauryl Lactate, Dimethyl Isosorbide, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Tetrahexyldecyl Ascorbate, Ergothioneine, Benzylidene Dimethoxydimethylindanone, Arabidopsis Thaliana Extract, Carnosine, Camellia Sinensis Leaf Extract, Vitis Vinifera Seed Extract Grape Seed Extract, Theobroma Cacao Seed Extract, Curcuma Longa Root Extract, Olea Europaea Fruit Extract Olive Fruit Extract, Euterpe Oleracea Fruit Extract, Trifluoroacetyl Tripeptide-2, Buddleja Officinalis Flower Extract, Coffea Arabica Extract Cell Leaf, Crocus Sativus Extract Cell Leaf Culture, Superoxide Dismutase, Ubiquinone, Zingiber Officinale Root Extract, Ceramide Np, Ceramide Ap, Ceramide Eop, Linoleic Acid, Linolenic Acid, Sea Whip Extract, Bisabolol, Tocopherol, Tocopheryl Acetate, Cholesterol, Phytosphingosine, Jojoba Esters, Sodium Pca, Pentylene Glycol, Methyl Gluceth-20, Glycerin, Helianthus Annuus Wax Seed Sunflower Wax Seed, Acacia Decurrens Wax Flower, Lecithin, Sodium Lauroyl Lactylate, Dicetyl Phosphate, Propanediol Dicaprylate Caprate, Polyglycerin-3, Ceteth-20 Phosphate, Diisostearyl Malate, Xanthan Gum, Steareth-2, Acacia Senegal Gum, Carbomer, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Dextran, Sodium Hydroxide, Citric Acid, Disodium Edta, Ethylhexylglycerin, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skinbetter-science/alto-defense-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/skinbetter-science/alto-defense-serum/for/mature-skin (this page)
- Germany: https://lovi.care/skincare/de/p/skinbetter-science/alto-defense-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/skinbetter-science/alto-defense-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/skinbetter-science/alto-defense-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/skinbetter-science/alto-defense-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/skinbetter-science/alto-defense-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/skinbetter-science/alto-defense-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/skinbetter-science/alto-defense-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/skinbetter-science/alto-defense-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skinbetter-science/alto-defense-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skinbetter-science/alto-defense-serum/for/mature-skin