# SKIN1004 Madagascar Centella Probio-cica Intensive Ampoule for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Brand: [SKIN1004](https://lovi.care/skincare/ie/brands/skin1004)
Category: [Serums and treatments](https://lovi.care/skincare/ie/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Offers excellent skin barrier resilience for your normal skin, as Lactobacillus Centella Asiatica Extract Ferment Filtrate and Ceramide NP work synergistically to enhance barrier function and hydration.
- Provides moderate benefits for wrinkles and fine lines due to the presence of Centella Asiatica Extract and Lactobacillus Centella Asiatica Extract Ferment Filtrate, which support skin barrier function and hydration.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing agents like Centella Asiatica Extract and Panthenol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Lactobacillus Centella Asiatica Extract Ferment Filtrate, Centella Asiatica Extract, Ceramide Np, Allantoin, Panthenol

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- A combination serum containing galactomyces ferment filtrate, dexpanthenol, and Centella asiatica effectively treated post-acne hyperpigmentation in subjects with colored skin by significantly increasing lightness scores in Fitzpatrick skin type V and reducing the melanin index in Fitzpatrick skin type IV compared to placebo. ([Skinmed, 2021](https://pubmed.ncbi.nlm.nih.gov/33938432/))

## What reviewers say

This ampoule is widely celebrated for repairing damaged skin barriers and soothing irritation, particularly for dry, sensitive, or mature skin types. Users consistently praise its rich, milky texture that provides deep hydration and a radiant glow without a sticky residue. However, it is often deemed too heavy for oily skin or humid weather. This summary is based on a very large amount of data and should be definitely taken into account.

- Liked: Soothing and calming (mostly mentioned)
- Liked: Deeply moisturizing (often mentioned)
- Liked: Luxurious texture (often mentioned)
- Liked: Barrier repair (sometimes noted)
- Disliked: Too heavy (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Dropper issues (rarely noted)
- Disliked: Scent concerns (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes SKIN1004 Probio-cica Intensive Ampoule a great fit for mature skin?

This product is a great fit because it strengthens your skin barrier and keeps it hydrated with Lactobacillus Centella Asiatica Extract Ferment Filtrate and Ceramide NP. It also helps smooth out fine lines and wrinkles while keeping your skin calm and comfortable.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit because Lactobacillus Centella Asiatica Extract Ferment Filtrate and Ceramide NP work together to strengthen your skin barrier and boost moisture. Centella Asiatica Extract and panthenol also help smooth fine lines and keep your skin calm with an extremely low chance of irritation.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Lactobacillus do for mature skin?

Topical products with Lactobacillus help mature skin by boosting hydration, firmness, and elasticity while improving overall skin smoothness and reducing the look of wrinkles. These ingredients work by strengthening the skin barrier and supporting collagen, making them a great fit for addressing signs of aging.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36718014/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38174442/)

### What does Centella Asiatica Extract do for mature skin?

Centella Asiatica Extract helps mature skin by improving moisture, reducing moisture loss, and supporting collagen production to keep skin firm and smooth. It also provides antioxidant and calming benefits that help protect against everyday stress and visible signs of aging.
Sources: [Scientific Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34188145/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516082/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing, following the recommended steps for mature skin. Using it at night helps keep things simple and safe around sun exposure while supporting your skin barrier and hydration.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment first and following with your retinol to keep your skin calm and hydrated. Panthenol and Centella Asiatica Extract help soothe the skin and reduce potential irritation from strong products.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### How often should I use this serum?

This treatment is best used in the evening as part of your routine for mature skin, which helps keep things simple and safe around sun exposure. It is unlikely to cause irritation, so you can safely use it every night to help smooth out fine lines and keep your skin feeling hydrated and strong.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts, as reviewers rarely report them and the formula includes soothing ingredients like Panthenol and Centella Asiatica Extract that are gentle on the skin.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ie/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €185.00 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/ie/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €31.40 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/ie/p/augustinus-bader/the-serum/for/mature-skin) — High fit — €385.99 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ie/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €56.86 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ie/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.28 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/ie/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €50.82 at Amazon

## Where to buy

- Amazon.ie: €20.54 (https://www.amazon.ie/dp/B0CSDMNRGM?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- Notino: €15.60 (https://www.notino.ie/skin1004/madagascar-centella-probio-cica-intensive-ampoule-soothing-serum-to-restore-the-skin-barrier/p-16210312/)
- Lookfantastic: €22.50 (https://www.lookfantastic.ie/p/skin1004-madagascar-centella-probio-cica-intensive-ampoule-50ml/16858551/)
Prices checked 15 Oct – 5 Nov 2026.

## Ingredients

Lactobacillus Centella Asiatica Extract Ferment Filtrate, Centella Asiatica Extract, Ceramide Np, Polyhydroxystearic Acid, Betaine, Allantoin, Panthenol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin (this page)
- Germany: https://lovi.care/skincare/de/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin
- France: https://lovi.care/skincare/fr/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skin1004/madagascar-centella-probio-cica-intensive-ampoule/for/mature-skin