# SKIN1004 Madagascar Centella Hyalu-Cica First Ampoule for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Superior · Safety: High.

Page: https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Brand: [SKIN1004](https://lovi.care/skincare/ie/brands/skin1004)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ie/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Highly suitable for your normal skin, this ampoule effectively addresses wrinkles and fine lines with high concentrations of Centella Asiatica Extract and Sodium Hyaluronate, which deeply hydrate and promote skin regeneration.
- Niacinamide and Glycerin further enhance the formula's moisturizing and soothing capabilities, supporting overall skin health and comfort.
- The product boasts an excellent safety profile, with no risk of irritation due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica, Sodium Hyaluronate, Niacinamide, Glycerin, Curcuma Longa Extract

## What the research says

- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties. ([Skin Pharmacology and Physiology, 2023](https://pubmed.ncbi.nlm.nih.gov/38008088/))
- Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models. ([Drug Discovery Today, 2017](https://pubmed.ncbi.nlm.nih.gov/28711364/))
- A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation. ([Saudi Pharmaceutical Journal, 2024](https://pubmed.ncbi.nlm.nih.gov/38178851/))

## What reviewers say

Based on a very large amount of data, this ampoule is widely praised as a holy grail for oily, combination, and sensitive skin types due to its incredibly lightweight, water-like texture that deeply hydrates without clogging pores. While it excels at soothing redness and prepping the skin for makeup, users with very dry skin often find it insufficient as a standalone moisturizer, particularly during colder months.

- Liked: Lightweight hydration (mostly mentioned)
- Liked: Rapid absorption (mostly mentioned)
- Liked: Soothing and calming (often mentioned)
- Liked: Makeup compatibility (sometimes noted)
- Liked: Value for money (sometimes noted)
- Disliked: Insufficient for dry (sometimes noted)
- Disliked: Breakouts rare (rarely noted)
- Disliked: Lack of wow (rarely noted)
- Disliked: Runny texture (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes SKIN1004 Hyalu-Cica First Ampoule a great fit for mature skin?

This ampoule is a great fit for mature skin because it deeply hydrates and helps smooth out fine lines and wrinkles using high concentrations of Centella Asiatica and Sodium Hyaluronate. Niacinamide and glycerin further boost moisture and comfort while keeping the skin calm and supported. It is very safe and unlikely to cause irritation.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this ampoule a good fit for mature skin?

This ampoule is a great fit for mature skin because it contains Centella Asiatica and sodium hyaluronate, which deeply hydrate and help smooth out fine lines and wrinkles. Niacinamide and glycerin further boost moisture and comfort, keeping this type of skin soft and healthy.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Centella Asiatica do for mature skin?

Centella asiatica helps mature skin by boosting moisture, keeping it smooth, and supporting collagen to make skin look firmer and less wrinkled. It also helps calm redness and protect skin from daily stress and aging.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516082/), [Scientific Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34188145/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this ampoule go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. Centella Asiatica Extract and Sodium Hyaluronate help deeply hydrate this skin and smooth out fine lines.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Can I use this ampoule with retinol, and in what order?

You can use this ampoule with retinol, applying the ampoule first to deeply hydrate and calm your skin before putting on your retinol. Using a hydrating and soothing product like this helps keep your skin comfortable and is unlikely to cause irritation.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### How often should I use this ampoule?

You can use this ampoule in your evening routine, and some people may also use it in the morning or twice a day. Daily application helps deeply hydrate mature skin and visibly improve fine lines, wrinkles, and overall texture.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this ampoule clog pores, cause breakouts or purging for mature skin?

This ampoule is unlikely to cause breakouts or clog pores for mature skin. It has a very safe formula with no harsh ingredients, making irritation and breakouts negligible.

### Can I use this ampoule around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on the body because its gentle ingredients and soothing components are very safe for delicate skin. Applying hydrating formulas to these areas helps smooth fine lines and keeps thin skin plump and soft.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Journal of Biomedical Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28808192/)

### Is this ampoule fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/ie/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/mature-skin) — Average fit — €35.40 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/ie/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/mature-skin) — Average fit — €37.20 at Amazon
- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/ie/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/mature-skin) — High fit — €23.90 at Notino

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ie/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €56.86 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ie/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.28 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ie/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — €26.27 at Amazon

## Where to buy

- Amazon.ie: €15.69 (https://www.amazon.ie/dp/B0CTTRDRBK?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- Notino: €18.00 (https://www.notino.ie/skin1004/madagascar-centella-hyalu-cica-first-ampoule-revitalising-moisturising-serum/p-16231301/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Centella Asiatica Extract, Butylene Glycol, Niacinamide, 1,2-Hexanediol, Water, Hydroxyacetophenone, Carbomer, Glycereth-25 Pca Isostearate, Ethylhexylglycerin, Tromethamine, Sodium Hyaluronate, Betula Platyphylla Japonica Juice, Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Propanediol, Musa Sapientum Flower Extract, Coccinia Indica Fruit Extract, Rosa Damascena Flower Water, Pyrus Communis Fruit Extract, Prunus Domestica Fruit Extract, Aloe Barbadensis Flower Extract, Cucumis Melo Fruit Extract, Solanum Melongena Fruit Extract, Hedera Helix Stem Extract Leaf, Ocimum Sanctum Leaf Extract, Glycerin, Anastatica Hierochuntica Extract, Corallina Officinalis Extract, Curcuma Longa Root Extract, Hydrolyzed Hyaluronic Acid, Portulaca Oleracea Extract, Artemisia Princeps Extract, Rhodiola Rosea Root Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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- United Kingdom: https://lovi.care/skincare/uk/p/skin1004/madagascar-centella-hyalu-cica-first-ampoule/for/mature-skin
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