Peter Thomas Roth PEPTIDE SKINJECTION for mature skin
Glycerin
Tetrapeptide-1
Hyaluronic Acid
High
- HighNormal Skin Fit
- AverageEffectiveness
- HighSafety
One of the best moisturizers for mature skin.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for your wrinkles and fine lines, as hyaluronic acid and glycerin provide essential hydration and plumping effects for normal skin. Squalane further supports skin suppleness with its emollient properties.
- Niacinamide and adenosine contribute to overall skin health and radiance, complementing the primary hydrating ingredients.
- The product is safe for your normal skin, with no reported risks of irritation due to the absence of harsh or prohibited substances.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
People Say
★4.6Overall rating based on 200+ reviewsThis product line is highly praised for its effectiveness in softening fine lines and improving skin texture, with many users reporting smoother and more hydrated skin. Some users have noted a gritty texture in the serum and varying results for deep wrinkle reduction.
Highlights
Reduces fine lines Mostly Mentioned
- “Big change in forehead lines”
- “lines around eyes decreased”
- “definite reduction in lines”
Smooths skin texture Often Mentioned
- “Skin has never felt so smooth”
- “makeup goes on smooth”
- “melts into my skin”
Hydrating formula Sometimes Noted
- “Thick hydrating feel”
- “skin feels more hydrated”
- “helps hydrate”
Reduces eye puffiness Sometimes Noted
- “Less puffiness under eyes”
- “quick relief of puffiness”
- “noticed less puffiness”
Gritty serum texture Sometimes Noted
- “Lotion has a little grit”
- “texture is a little gritty”
- “creamy and a bit gritty”
High price point Sometimes Noted
- “hefty price”
- “less hefty price”
Drying sensation Rarely Noted
- “A bit drying”
- “skin did not feel oily”
Slow/No results Rarely Noted
- “Not noticed any reduction”
- “only been 12 days”
- “didn't last a week”
Sources: lovi.care, peterthomasroth.com, lovelyskin.com, dermstore.com, reddit.com, and more
Questions and answers
What makes Peter Thomas Roth Peptide Skinjection a great fit for mature skin?
Peter Thomas Roth Peptide Skinjection is a great fit for mature skin because hyaluronic acid and glycerin give essential moisture and plumping effects, while squalane helps keep the skin soft. Niacinamide and adenosine also support overall skin health and radiance.
Dermatologic Therapy, 2022Clinical, Cosmetic and Investigational Dermatology, 2017
Which ingredients make this moisturizing treatment a good fit for mature skin?
Glycerin, hyaluronic acid, and squalane make this moisturizing treatment a great fit by providing essential hydration, plumping up fine lines, and keeping your skin soft. Niacinamide and adenosine also help boost overall skin health and radiance.
Clinical, Cosmetic and Investigational Dermatology, 2017Dermatologic Therapy, 2022
What does Glycerin do for mature skin?
Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
The British Journal of Dermatology, 2008Clinical, Cosmetic and Investigational Dermatology, 2017
What does Tetrapeptide-1 do for mature skin?
Tetrapeptide-1 helps smooth out fine lines and wrinkles while supporting firm, elastic skin as you age. It encourages collagen production and helps protect against everyday skin stress.
Where does this moisturizing treatment go in a skincare routine for mature skin?
This moisturizing treatment goes in the evening routine after cleansing and before moisturizing, as treatments with actives fit best at night for simplicity and extra safety around sun exposure. It is safe for mature skin with no reported risks of irritation.
Can I use this moisturizing treatment with retinol, and in what order?
You can use this moisturizing treatment with retinol by applying the treatment after your retinol to help calm the skin and keep it soft and smooth. Using a hydrating moisturizer alongside retinol helps reduce dryness and supports the skin barrier during treatment.
How often should I use this moisturizing treatment?
You can use this moisturizing treatment in the evening as part of your routine. Daily application helps improve skin hydration, fine lines, and overall texture.
Journal of Cosmetic Dermatology, 2020Journal of Drugs in Dermatology, 2015
Can this moisturizing treatment clog pores, cause breakouts or purging for mature skin?
This moisturizing treatment is unlikely to clog pores or cause breakouts for mature skin, as it has a safe formula with no reported risks of irritation or harsh substances. It features ingredients like squalane and glycerin that keep skin smooth and hydrated without feeling heavy.
Clinical, Cosmetic and Investigational Dermatology, 2017Molecules, 2025
Can I use this moisturizing treatment around the eyes or on my body?
This moisturizing treatment is well-suited for the thin skin around the eyes and body because its gentle formula provides essential hydration and plumping effects without irritation. Regular application helps smooth fine lines while keeping delicate skin soft and comfortable.
Polymers, 2023Clinical, Cosmetic and Investigational Dermatology, 2017
Is this moisturizing treatment fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.
Scientific Reports, 2024The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019
Ingredients
Water, Glycerin, Chondrus Crispus Powder, Butylene Glycol, Tetrapeptide-1, Hyaluronic Acid, Allantoin, Trehalose, Caffeine, Squalane, Niacinamide, Adenosine, Tocopheryl Acetate, Calcium Lactate, Opuntia Ficus-Indica Flower Extract, Chondrus Crispus Extract, Chlorphenesin, Ricinus Communis Seed Oil Castor Seed Oil, Potassium Chloride, Dextrin, Sodium Phytate, Caprylyl Glycol, Citric Acid, Ceratonia Siliqua Gum, Xanthan Gum, Peg-60 Hydrogenated Castor Oil, Ultramarines, Chromium Hydroxide Green Ci 77289, Phenoxyethanol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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