# Peter Thomas Roth Peptide 21 Wrinkle Resist Serum for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: Superior · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ie/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Brand: [Peter Thomas Roth](https://lovi.care/skincare/ie/brands/peter-thomas-roth)
Category: [Serums and treatments](https://lovi.care/skincare/ie/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other serums fit it better.

## Why this fit

- Offers excellent wrinkle reduction for you due to the presence of multiple peptides like Tripeptide-10 Citrulline and Acetyl Octapeptide-3, which firm and smooth texture, while Glycerin and Sodium Hyaluronate provide essential hydration for your dry skin.
- The formula is safe for your dry skin, as it contains no harsh ingredients and includes soothing agents like Glycerin and Sodium Hyaluronate.
- While it offers general skincare benefits and hydration, it lacks specialized ingredients to directly address your primary concern of dry or flaky skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ie/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ie/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/ie/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ie/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ie/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ie/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ie/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ie/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ie/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Complex Of 21 Peptides, Neuropeptides, Squalane, Sodium Hyaluronate, Ascorbic Acid, Retinyl Palmitate

## What the research says

- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))

## What reviewers say

Users frequently praise this serum for its lightweight, fast-absorbing formula that effectively hydrates and plumps the skin, leading to a visible reduction in fine lines on the forehead and neck. Some users find the product expensive and complain about a sticky residue or a metallic scent.

- Liked: Hydrates and plumps (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Improves texture (sometimes noted)
- Liked: Lightweight absorption (sometimes noted)
- Disliked: Sticky residue (sometimes noted)
- Disliked: Metallic scent (rarely noted)
- Disliked: Packaging issues (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Peter Thomas Roth Peptide 21 Wrinkle Resist Serum work for dry skin?

This serum works for your dry skin, though other products fit it better because it lacks specialized ingredients to directly address dryness and flakiness. To better care for dry skin, a product of this type needs highly effective hydrating and soothing ingredients, along with skin barrier support from ceramides, propolis, niacinamide, or bifida fermentation.
Sources: [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry skin?

Glycerin and Sodium Hyaluronate make this serum a good fit for dry skin by providing essential hydration. To better fit dry skin, a product of this type needs highly effective, soothing ingredients that provide significant hydration and support skin health without any risk of irritation, such as ceramides, propolis, niacinamide, or bifida fermentation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Peptide Complex do for dry skin?

Peptide Complex helps keep dry skin hydrated and smooth. Studies show that peptide supplements can increase skin water content, improve elasticity, and help maintain a healthy moisture barrier.
Sources: [Skin Pharmacology and Physiology, 2021](https://pubmed.ncbi.nlm.nih.gov/33774639/), [Journal of Microbiology and Biotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40935395/)

### What do Neuropeptides do for dry skin?

Neuropeptides help manage the intense itch and inflammation linked with dry skin by targeting the nerve signals in your skin. Using products that focus on these nerve pathways may help calm down irritated, itchy skin.
Sources: [International Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/18494919/), [International Archives of Allergy and Immunology, 2026](https://pubmed.ncbi.nlm.nih.gov/41052259/)

### Where does this serum go in a skincare routine for dry skin?

This serum goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening helps keep things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum in your routine, but apply your retinol first and follow with this treatment to keep your dry skin calm and comfortable. This product is unlikely to irritate your skin as it contains soothing ingredients like glycerin and sodium hyaluronate.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. It is unlikely to irritate dry skin, though a product for this skin needs rich hydrating ingredients and heavier oils to relieve dryness and flaky patches.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/)

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores or cause breakouts for dry skin, as its formula contains no harsh ingredients and is well-tolerated. To properly care for flaky or very dry skin, a product of this type needs richer moisturizing ingredients that deeply lock in moisture.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/ie/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — €14.94 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/ie/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €33.36 at Amazon
- [KraveBeauty Great Barrier Relief](https://lovi.care/skincare/ie/p/kravebeauty/great-barrier-relief/for/dry-skin) — Superior fit — €49.45 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/ie/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — €14.68 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ie/p/cosrx/propolis-synergy-toner/for/dry-skin) — Superior fit — €14.28 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/ie/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/dry-skin) — Superior fit — €50.82 at Amazon

## Where to buy

- Amazon.ie: €132.40 (https://www.amazon.ie/dp/B00YP582QA?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Glycerin, Rosa Centifolia Flower Water, Isopropyl Myristate, Squalane, Mannitol, Butylene Glycol, Natto Gum, Tripeptide-10 Citrulline, Acetyl Octapeptide-3, Palmitoyl Hexapeptide-12, Acetyl Tetrapeptide-11, Acetyl Hexapeptide-8, Acetyl Hexapeptide-1, Palmitoyl Oligopeptide, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Tripeptide-1, Palmitoyl Tetrapeptide-7, Hexapeptide-11, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Tripeptide-5, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-1, Sodium Polyglutamate, Sodium Hyaluronate, Tocopheryl Acetate, Retinyl Palmitate, Ascorbic Acid, Hydrolyzed Soy Protein, Hydrolyzed Wheat Protein, Lecithin, Pseudoalteromonas Extract Ferment, Acrylates Copolymer, Magnesium Chloride, Polysorbate 20, Dimethyl Isosorbide, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Leuconostoc Radish Root Ferment Filtrate, Peg-8 Dimethicone, Disodium Phosphate, Carbomer, Dextran, Sodium Lactate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Xanthan Gum, Triethanolamine, Sodium Phosphate, Octyldodecanol, Silica, Sodium Propoxyhydroxypropyl Thiosulfate Silica, Sodium Hydroxide, Caprylyl Glycol, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin (this page)
- Germany: https://lovi.care/skincare/de/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin