Perricone MD High Potency Hyaluronic Intensive Hydrating Serum for sensitive skin
Sodium Hyaluronate
Niacinamide
Squalane
Ceramide Np
Acetyl Glucosamine
High
- HighNormal Skin Fit
- SuperiorEffectiveness
- HighSafety
A great choice for sensitive skin; a few moisturizers fit it even better.
This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent for your normal skin and concerns with redness and irritation, as Niacinamide and Sodium Hyaluronate provide potent anti-inflammatory and hydrating benefits, calming your sensitive skin.
- The high concentrations of Sodium Hyaluronate Crosspolymer and Sodium Hyaluronate ensure superior moisturization, while Ceramide NP aids in barrier repair for overall skin health.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like Glycerin.
How to apply
- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
People Say
★4.8Overall rating based on 1000+ reviewsUsers consistently praise this serum for its ability to deliver immediate and deep hydration, often noting that it visibly plumps fine lines and leaves skin feeling exceptionally soft and smooth. While the vast majority find the texture elegant and fast-absorbing, a small minority of users find it slightly sticky or heavy compared to more watery serums.
Highlights
Deep hydration Mostly Mentioned
- “Immediate deep hydration”
- “quench dehydrated skin”
- “endlessly hydrated”
- “replenish moisture”
Fast absorbing Often Mentioned
- “Absorbs quickly”
- “sinks in beautifully”
- “non-greasy”
- “no residue”
Plumps fine lines Often Mentioned
- “Plumps wrinkles”
- “softened fine lines”
- “visibly plump”
- “diminish look of lines”
Smooths texture Often Mentioned
- “Skin feels softer”
- “smooth complexion”
- “supple feeling”
- “satin veil”
High price point Often Mentioned
- “Pricey”
- “expensive”
- “splurge”
- “investment”
Gentle on skin Sometimes Noted
- “Lovely on sensitive skin”
- “very healing”
- “no irritation”
- “soothing”
Heavy texture Rarely Noted
- “Not water-like”
- “silicone feel”
- “thicker than expected”
- “too rich”
Packaging issues Rarely Noted
- “Pump broke”
- “hard to dispense”
- “bottle design”
- “product left at bottom”
Scent Rarely Noted
- “Clinical smell”
- “unpleasant scent”
- “strong odor”
- “chemical smell”
Sticky feel Rarely Noted
- “Little sticky”
- “tacky finish”
- “sticky residue”
- “feels heavy”
Sources: lovi.care, perriconemd.com, dermstore.com, lookfantastic.com, ulta.com, lovelyskin.com, and more
Questions and answers
What makes Perricone MD High Potency Hyaluronic Intensive Hydrating Serum a great fit for sensitive skin?
This serum is a great fit because ingredients like niacinamide and sodium hyaluronate calm sensitive skin with powerful soothing and hydrating benefits, while ceramide NP helps repair the skin barrier. It also has a very safe profile with no harsh ingredients, making irritation unlikely.
Skin Pharmacology and Physiology, 2022Scientific Reports, 2024
Which ingredients make this serum a good fit for sensitive skin?
This serum is a great fit because ingredients like niacinamide and sodium hyaluronate calm your sensitive skin by easing redness and irritation, while ceramide NP helps repair your skin barrier. Its very safe formula is unlikely to cause irritation and includes soothing glycerin.
Skin Pharmacology and Physiology, 2022Scientific Reports, 2024
What does Hyaluronic Acid do for sensitive skin?
Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Journal of Drugs in Dermatology, 2025Journal of Cosmetic Dermatology, 2018
What does Niacinamide do for sensitive skin?
Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Where does this serum go in a skincare routine for sensitive skin?
This treatment goes in the evening routine after your toner and before your moisturizer. Putting it in the evening keeps things simple and provides extra safety around sun exposure.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying it right before your retinol to help keep your skin calm and hydrated. A barrier-enhancing moisturizer helps reduce the dryness and irritation that often come with using retinol.
How often should I use this serum?
This serum is a great fit for your sensitive skin and is used in the evening as part of your routine. Daily application helps keep your skin calm and hydrated, while lowering any risk of irritation.
Can this serum clog pores, cause breakouts or purging for sensitive skin?
This serum is unlikely to clog pores, cause breakouts, or lead to purging on sensitive skin. It features a safe formula with soothing ingredients like niacinamide and glycerin, and it has an excellent suitability profile with no harsh components that typically trigger irritation.
Can I use this serum around the eyes or on my body?
You can safely use this moisturizing treatment around the eyes and on the body because it has an excellent safety profile and lacks harsh ingredients. Its soothing components and gentle hydrators help keep delicate areas soft and calm without causing irritation.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.
Scientific Reports, 2024A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths significantly improved skin barrier recovery rate, stratum corneum integrity, and hydration compared to a vehicle cream in healthy adult male volunteers with corticosteroid-impaired skin.
Skin Pharmacology and Physiology, 2022A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide.
Journal of Cosmetic Dermatology, 2007N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers.
Advanced Pharmaceutical Bulletin, 2016Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants.
Journal of Cosmetic and Laser Therapy, 2019
Ingredients
Water, Dimethicone, Butylene Glycol, Niacinamide, Acetyl Glucosamine, Squalane, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysilicone-11, Cetearyl Olivate, Hdi Trimethylol Hexyllactone Crosspolymer, Polyisobutene, Sorbitan Olivate, Dimethyl Isosorbide, Polysorbate 20, 1,2-Hexanediol, Caprylyl Glycol, Dimethyl Mea, Hydroxyacetophenone, Citric Acid, Ceramide Np, Caprylyl Capryl Glucoside, Sorbitan Oleate, Sodium Gluconate, Spermidine, Silica, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Phenoxyethanol, Phytosphingosine, Sodium Hyaluronate Crosspolymer, Ethylhexylglycerin, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Glycerin, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Magnesium Sulfate
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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