Perricone MD Deep Crease Serum for dry sensitive skin
Acyl-Glutathione- S-Palmitoylglutathione
Tetrahexyldecyl Ascorbate
Palmitoyl Tripeptide-5
Acetyl Hexapeptide-8
High
- HighDry Skin Fit
- HighEffectiveness
- HighSafety
A great choice for dry sensitive skin; a few serums fit it even better.
- Clinical, Cosmetic and Investigational Dermatology, 2017
- American Journal of Clinical Dermatology, 2013
This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for dry skin due to the presence of Squalane and Glycerin, which provide emollient and humectant actions respectively, supporting skin hydration and barrier function.
- The serum offers excellent wrinkle reduction for you due to the presence of Palmitoyl Tripeptide-5 and Acetyl Hexapeptide-8 in moderate concentrations for minimizing fine lines and wrinkles.
- There are no risks of irritation for your dry and sensitive skin due to the absence of prohibited or harsh ingredients.
How to apply
- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
People Say
★4.5Overall rating based on 800+ reviewsUsers in their 40s and 50s frequently praise this serum for its lightweight, non-greasy feel and its ability to hydrate and soften the appearance of expression lines. While results are gradual, consistent use leads to firmer, smoother-looking skin.
Highlights
Lightweight texture Mostly Mentioned
- “Absorbs quickly”
- “not sticky or greasy”
- “feels silky and smooth”
Hydrating formula Often Mentioned
- “Skin drinks it up”
- “leaves skin feeling plump”
- “adds a boost of moisture”
Softens deep lines Often Mentioned
- “Deeper lines look softer”
- “smile lines appear less pronounced”
- “frown lines look less visible”
High price point Often Mentioned
- “Price is quite premium”
- “barrier for some”
- “expensive investment”
Improves firmness Sometimes Noted
- “Skin feeling firmer”
- “noticeable improvement in bounce”
- “more lifted look”
Dropper issues Sometimes Noted
- “Difficult to pick up product”
- “dropper doesn't work well”
- “inconsistent dispensing”
Gradual results Sometimes Noted
- “Not an overnight miracle”
- “results are subtle”
- “haven't seen 11s improve yet”
Fragrance sensitivity Rarely Noted
- “Rose scent may not be ideal”
- “not for those with fragrance allergies”
Sources: lovi.care, perriconemd.com, dermstore.com, ulta.com, youtube.com, reddit.com, and more
Questions and answers
What makes Perricone MD Deep Crease Serum a great fit for dry sensitive skin?
This serum is a great fit because it uses squalane and glycerin to keep dry skin soft and hydrated while supporting your skin barrier. It also helps smooth out fine lines and wrinkles using peptides without any harsh ingredients that might cause irritation.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013
Which ingredients make this serum a good fit for dry sensitive skin?
Squalane and glycerin make this serum a great fit by keeping your skin hydrated and supporting its protective barrier, while peptides like acetyl hexapeptide-8 help smooth out fine lines. It is very unlikely to cause irritation for dry and sensitive skin because it avoids harsh ingredients.
Clinical, Cosmetic and Investigational Dermatology, 2017American Journal of Clinical Dermatology, 2013
What does Acyl-Glutathione do for dry sensitive skin?
Acyl-Glutathione helps protect dry sensitive skin against environmental and oxidative stress while improving overall moisture and smoothness. It is unlikely to cause irritation and supports a calm, healthy look.
Journal of the European Academy of Dermatology and Venereology, 2024Clinical, Cosmetic and Investigational Dermatology, 2014
What does Palmitoyl Glutathione do for dry sensitive skin?
Palmitoyl Glutathione helps improve moisture content and smoothness for dry sensitive skin. Clinical studies show that topical oxidized glutathione significantly increases moisture and softness while maintaining a very safe profile on the skin.
Where does this serum go in a skincare routine for dry sensitive skin?
This serum goes in your evening routine after your toner and before your moisturizer. Putting it in the evening keeps things simple and adds extra safety around sun exposure.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the treatment after your retinol or on alternating nights to keep your dry skin calm and comfortable. This approach helps minimize potential dryness or irritation while still letting you target fine lines effectively.
How often should I use this serum?
This serum is a great fit for your dry sensitive skin and works best in your evening routine. Using it at night keeps things simple and safe, and it is unlikely to cause irritation.
Can this serum clog pores, cause breakouts or purging for dry sensitive skin?
This serum is unlikely to clog pores, cause breakouts, or lead to purging on dry sensitive skin because it contains no harsh or heavy ingredients that typically trigger irritation. It is formulated to be gentle while helping smooth fine lines and support skin hydration.
Is this serum fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool).
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.
Journal of Cosmetic and Laser Therapy, 2013Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects.
Colloids and Surfaces. B, Biointerfaces, 2025Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.
European Journal of Neurology, 2013Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.
International Journal of Biological Macromolecules, 2026
Ingredients
Water, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic Capric Triglyceride, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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