Olay Regenerist Retinol 24 Night Facial Serum for mature skin
Retinol
Niacinamide
Palmitoyl Pentapeptide-4
Glycerin
Retinyl Propionate
High
- SuperiorNormal Skin Fit
- HighEffectiveness
- HighSafety
A great choice for mature skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent suitability for your normal skin is provided by the superb combination of retinol, retinyl propionate, and niacinamide, which offer potent anti-aging benefits and support skin regeneration.
- The serum offers relevant benefits for your wrinkles and fine lines due to the presence of retinol, retinyl propionate, and palmitoyl pentapeptide-4 in concentrations that promote skin rejuvenation.
- There are no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.6Overall rating based on 1.6k+ reviewsBased on a very large amount of data, this serum is highly praised for delivering significant anti-aging results like firmer skin and reduced fine lines, with a notable absence of typical retinol irritation. Its lightweight, hydrating, and fragrance-free formula is well-suited for sensitive skin, effectively improving texture and evening out skin tone over time.
Highlights
Smoother skin texture Mostly Mentioned
- “skin feels like silk”
- “woke up to soft skin”
- “texture is much smoother”
- “bumps are gone”
- “face feels baby soft”
Gentle and non-irritating Often Mentioned
- “no redness or peeling”
- “great for sensitive skin”
- “zero irritation”
- “gentlest retinol I've used”
- “didn't dry me out”
Lightweight and fast-absorbing Often Mentioned
- “absorbs almost instantly”
- “not greasy at all”
- “lightweight milky texture”
- “sinks right in”
- “doesn't feel heavy”
Brightens and evens tone Sometimes Noted
- “faded my dark spots”
- “complexion looks brighter”
- “helped with acne scars”
- “skin tone is more even”
- “glowy morning skin”
Hydrating and plumping Sometimes Noted
- “skin looks plumped”
- “very moisturizing”
- “hydrates well overnight”
- “no need for extra cream”
- “woke up glowing”
Poor dropper design Sometimes Noted
- “dropper is clunky”
- “hard to get product out”
- “button mechanism fails”
- “bottle design is frustrating”
- “dispenses inconsistently”
Slow visible results Sometimes Noted
- “took months to see difference”
- “no immediate miracle”
- “slow progress on deep wrinkles”
- “needs consistent use”
- “hard to tell difference at first”
Caused breakouts Rarely Noted
- “caused minor purging”
- “broke me out initially”
- “small whiteheads appeared”
- “clogged my pores”
- “reaction on chin”
Pilling or residue Rarely Noted
- “leaves a white film”
- “pills under moisturizer”
- “feels slightly sticky”
- “residue on pillow”
- “doesn't layer well”
Texture preference Rarely Noted
- “prefer the cream version”
- “too watery for me”
- “wanted something thicker”
- “runs off hand easily”
- “cream feels more luxurious”
Sources: lovi.care, walmart.com, target.com, byrdie.com, youtube.com, skinsort.com, and more
Questions and answers
What makes Olay Retinol 24 Serum a great fit for mature skin?
This serum is a great fit for mature skin because its combination of retinol, retinyl propionate, and niacinamide supports skin regeneration and helps smooth out fine lines and wrinkles. It is very well suited for normal skin and is unlikely to cause irritation.
Which ingredients make this serum a good fit for mature skin?
This serum is a great fit for mature skin due to a superb combination of retinol, retinyl propionate, and niacinamide that offers potent anti-aging benefits and supports skin regeneration. Additionally, palmitoyl pentapeptide-4 helps smooth out wrinkles and fine lines to promote skin rejuvenation.
What does Retinol do for mature skin?
Retinol helps smooth out fine lines and wrinkles while improving overall skin thickness and firmness over time. It may also cause temporary dryness, scaling, or stinging as your skin gets used to it.
What does Niacinamide do for mature skin?
Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Where does this serum go in a skincare routine for mature skin?
This serum goes in the evening routine after cleansing and toning, followed by a moisturizer. Putting treatments in the evening provides extra safety around sun exposure.
Can I use this serum with vitamin C, and in what order?
You can use this serum with vitamin C by applying vitamin C in your morning routine and this treatment at night, as this helps prevent irritation while supporting your skin. This product is a great fit for your mature skin, offering potent anti-aging benefits and helping to smooth fine lines and wrinkles safely.
How often should I use this serum?
Use this serum in your evening routine to smooth fine lines and help renew mature skin safely. This product is a great fit and is unlikely to irritate normal skin when applied as part of your nightly routine.
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to cause breakouts or clog pores for mature skin, as it has a very low risk of irritation and no harsh ingredients. However, because it contains retinol, you may experience mild purging when you first start using it as your skin adjusts.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women.
The British Journal of Dermatology, 2010A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation.
International Journal of Cosmetic Science, 2024Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects.
International Journal of Cosmetic Science, 2005Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle.
International Journal of Cosmetic Science, 2017Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.
The British Journal of Dermatology, 2019Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity.
Journal of Controlled Release, 2018Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question.
The Journal of Clinical and Aesthetic Dermatology, 2021Topical retinyl propionate cream produced no statistically significant differences compared to placebo for any clinical, histological, or profilometric parameters of skin photoageing in 80 subjects.
Clinical and Experimental Dermatology, 1998A vitamin A palmitate and antioxidant-containing oil-based moisturizer improved fine lines, wrinkles, pigmentation, tone, texture, dryness, firmness, and clarity across various body sites compared to a no-treatment group over 12 weeks.
Journal of Cosmetic Dermatology, 2013
Ingredients
Water, Dimethicone, Glycerin, Retinol, Retinyl Propionate, Niacinamide, Palmitoyl Pentapeptide-4, Dimethicone Crosspolymer, Polyacrylamide, Titanium Dioxide, C13-14 Isoparaffin, Dmdm Hydantoin, Mica, Polysorbate 20, Laureth-4, Laureth-7, Disodium Edta, Iodopropynyl Butylcarbamate, Caprylic Capric Triglyceride
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.