# MISSHA Vita C Plus Spot Correcting & Firming Ampoule for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ie/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Brand: [MISSHA](https://lovi.care/skincare/ie/brands/missha)
Category: [Serums and treatments](https://lovi.care/skincare/ie/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers excellent treatment for brightening and evening skin tone, as 3-O-Ethyl Ascorbic Acid and Tranexamic Acid work synergistically to address hyperpigmentation and promote a more uniform complexion for your oily skin. Niacinamide further supports oil regulation and antioxidant effects, directly benefiting your concerns with acne, blemishes, and breakouts.
- The inclusion of licorice root extract and allantoin provides soothing benefits, ensuring comfort and minimizing potential irritation for your oily skin.
- The product demonstrates a high safety profile with no risks of irritation due to the absence of harsh ingredients and the presence of beneficial soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ie/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/ie/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ie/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/combination-skin): Superior
- [Sensitive skin](https://lovi.care/skincare/ie/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ie/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/ie/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ie/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ie/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/ie/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Ascorbic Acid, Niacinamide, Tranexamic Acid, Bifida Lysate Ferment, Liposome Formula

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- A multi-component dissolving microneedle patch loaded with glabridin, 3-O-ethyl-L-ascorbic acid, and tranexamic acid effectively reduced chloasma and age spots while demonstrating safety in clinical evaluation, alongside significant antioxidant, anti-tyrosinase, and melanin-reduction effects in vitro and in vivo. ([Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- Ammonium glycyrrhizinate-loaded ultradeformable liposomes decreased skin inflammation in healthy human volunteers when compared to standard delivery. ([Colloids and Surfaces. B, Biointerfaces, 2020](https://pubmed.ncbi.nlm.nih.gov/32535351/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Liposomes loaded with anti-tyrosinase bioactive tripeptides achieved 20-30% encapsulation efficiency, exhibited no cytotoxicity toward reconstructed human epidermis cells, and facilitated epidermal retention of the CSF tripeptide without significant systemic permeation in an ex vivo human skin assay. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40508130/))
- Ascorbate phosphatidylcholine liposomes improved skin penetration and provided preventive antioxidant and anti-inflammatory effects against UV irradiation in human skin compared to unformulated active. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26719718/))
- Topical administration of liposomes co-loaded with quercetin and resveratrol reduced tissue damage, oedema, and leukocyte infiltration in a mouse model of skin lesion. ([International Journal of Pharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27609664/))

## What reviewers say

Users with dull, aging, or hyperpigmented skin frequently praise this ampoule for its ability to brighten the complexion and fade dark spots without causing irritation. Many reviewers report that the product provides a "healthy glow" and significant hydration, leaving skin feeling plumper and smoother, though results regarding deep wrinkles or old scars can take time.

- Liked: Effective brightening (mostly mentioned)
- Liked: Gentle formula (often mentioned)
- Liked: Hydrating texture (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Disliked: Sticky finish (sometimes noted)
- Disliked: Scent sensitivity (rarely noted)
- Disliked: Skin reactions (rarely noted)
- Disliked: Slow results (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes MISSHA Vita C Plus Ampoule a great fit for oily acne-prone skin?

This ampoule is a great fit because ingredients like 3-O-Ethyl Ascorbic Acid and Tranexamic Acid help fade dark spots while keeping your skin tone even. Niacinamide also supports oil regulation to manage breakouts, while licorice root extract and allantoin calm the skin and keep irritation unlikely.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

This serum is a great fit for your oily acne-prone skin because 3-O-Ethyl Ascorbic Acid and Tranexamic Acid brighten dark spots, while Niacinamide helps balance oil and calm breakouts. Licorice root extract and allantoin also keep your skin comfortable and are unlikely to cause irritation.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/)

### What does Vitamin C do for oily acne-prone skin?

Vitamin C helps brighten skin, smooth out texture, and improve uneven spots for oily acne-prone skin. It may also help fade marks left behind by blemishes.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Putting it in the evening helps keep your routine simple and adds safety around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this treatment with retinol by applying this serum first and following it with your retinol product, or by using them on alternate nights to keep your skin calm. The formula's soothing ingredients like licorice root extract and allantoin help ensure comfort and minimize potential irritation when combining active routines.

### How often should I use this serum?

This treatment fits into your evening routine as an extra step after cleansing, which helps keep things simple and safe. You can use it in the evening, and it is unlikely to cause irritation thanks to its soothing ingredients.

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is a great fit and is unlikely to clog pores or cause breakouts for your oily acne-prone skin. It features helpful ingredients like niacinamide to support oil control and soothing components to keep irritation low, though a sticky finish is sometimes noted.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Colloids and Surfaces. B, Biointerfaces, 2020](https://pubmed.ncbi.nlm.nih.gov/32535351/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/ie/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — €14.94 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/ie/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — €29.07 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/ie/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — €31.40 at Amazon

## Pairs well with

- Cleanser: [IS Clinical Cleansing Complex](https://lovi.care/skincare/ie/p/is-clinical/cleansing-complex/for/oily-acne-prone-skin) — Superior fit — €95.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ie/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ie/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — €16.50 at Amazon

## Where to buy

- Amazon.ie: €23.06 (https://www.amazon.ie/dp/B09KNBVCNT?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- Notino: €40.00 (https://www.notino.ie/missha/vita-c-plus-antioxidant-face-firming-serum-for-pigment-spots-correction/p-16057221/)
Prices checked 12 Oct – 6 Nov 2026.

## Ingredients

Water, Hippophae Rhamnoides Water, Glycerin, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Methylpropanediol, Butylene Glycol, Niacinamide, Diethoxyethyl Succinate, 1,2-Hexanediol, Tocopheryl Acetate, 3-O-Ethyl Ascorbic Acid, Bifida Lysate Ferment, Tranexamic Acid, Sodium Polyacryloyldimethyl Taurate, Chlorella Vulgaris Extract, Glucose, Caprylic Capric Triglyceride, Glycine Soja Oil Soybean Oil, Fructooligosaccharides, Fructose, Arbutin, Hydrogenated Lecithin, Panthenol, Citrus Aurantium Dulcis Peel Oil, Xanthan Gum, Adenosine, Ethylhexylglycerin, Citric Acid, Polyquaternium-51, Ceramide Np, Grapefruit Peel Oil, Sodium Phytate, Eucalyptus Globulus Oil Leaf, Lavandula Angustifolia Oil Lavender Oil, Sodium Citrate, Daucus Carota Sativa Root Extract Carrot Root Extract, Beta-Carotene, Tocopherol, Hydrolyzed Collagen, Allantoin, Glyceryl Glucoside, Palmitoyl Tripeptide-5, Dipropylene Glycol, Caprylyl Glycol, Ascorbic Acid, Sodium Hyaluronate, Acetyl Hexapeptide-8, Pentylene Glycol, Pvp, Laurdimonium Hydroxypropyl Hydrolyzed Wheat Protein, Hydrolyzed Hyaluronic Acid, Phytosterols, Ascorbyl Glucoside, Fullerenes
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/oily-acne-prone-skin (this page)
- Germany: https://lovi.care/skincare/de/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/oily-acne-prone-skin
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- Spain: https://lovi.care/skincare/es/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/missha/vita-c-plus-spot-correcting-and-firming-ampoule/for/oily-acne-prone-skin