# MiamiMD Age Defying Lift & Firm Cream for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ie/p/miamimd/age-defying-lift-and-firm-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Brand: [MiamiMD](https://lovi.care/skincare/ie/brands/miamimd)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ie/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for normal skin, this cream effectively addresses wrinkles and fine lines with ingredients like Palmitoyl Tripeptide-5 and Acetyl Hexapeptide-8, which promote collagen synthesis and muscle relaxation, while Sodium Hyaluronate and Ceramide Ap provide essential hydration and barrier support.
- The formulation also includes Jojoba Seed Oil and Glycerin, known for their soothing properties, ensuring a comfortable experience for your normal skin.
- This product is safe for your skin, containing no harsh ingredients and featuring beneficial components that support skin health.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ie/p/miamimd/age-defying-lift-and-firm-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ie/p/miamimd/age-defying-lift-and-firm-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ie/p/miamimd/age-defying-lift-and-firm-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ie/p/miamimd/age-defying-lift-and-firm-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ie/p/miamimd/age-defying-lift-and-firm-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ie/p/miamimd/age-defying-lift-and-firm-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ie/p/miamimd/age-defying-lift-and-firm-cream/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ie/p/miamimd/age-defying-lift-and-firm-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ie/p/miamimd/age-defying-lift-and-firm-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Palmitoyl Tripeptide-1, Acetyl Hexapeptide-8, Sodium Hyaluronate, Ceramide Ng, Jojoba Seed Oil

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- An oil/water emulsion containing 10% Argireline reduced wrinkle depth up to 30% and inhibited neurotransmitter release in healthy women volunteers compared to baseline. ([International Journal of Cosmetic Science, 2002](https://pubmed.ncbi.nlm.nih.gov/18498523/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Clay jojoba oil facial masks reduced total skin lesions by a mean of 54% after 6 weeks in 133 participants with acne-prone, lesioned skin and mild acne compared to baseline. ([Forschende Komplementarmedizin, 2012](https://pubmed.ncbi.nlm.nih.gov/22585103/))
- Topical application of jojoba wax reduced LPS-induced secretion of IL-6, IL-8, and TNFα by approximately 30% and increased the synthesis of pro-collagen III and hyaluronic acid compared to untreated skin in an ex-vivo human skin organ culture model. ([Frontiers in Pharmacology, 2024](https://pubmed.ncbi.nlm.nih.gov/38344180/))
- Topical jojoba oil application in male mice decreased exercise-induced pro-inflammatory gene expression (Il-1b and Il-6 in soleus, Il-1b in gastrocnemius) compared to untreated exercised mice. ([Biomolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/41154623/))

## What reviewers say

Based on limited data, this product is frequently praised for its lightweight, non-greasy texture and its ability to hydrate and improve the appearance of fine lines and skin texture. Some users report a lack of visible results for deeper wrinkles or sagging skin, and a few express concerns about the product's price and company subscription policies.

- Liked: Lightweight texture (often mentioned)
- Liked: Hydrating and smoothing (sometimes noted)
- Liked: Improves fine lines (sometimes noted)
- Disliked: Lack of results (sometimes noted)
- Disliked: High price (rarely noted)
- Disliked: Subscription issues (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes MiamiMD Age Defying Lift & Firm Cream a great fit for mature skin?

MiamiMD Age Defying Lift & Firm Cream is a great fit for mature skin because it targets wrinkles and fine lines using Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-5 to help smooth the skin. It also provides essential moisture and barrier support with Sodium Hyaluronate and Ceramide Ap, keeping the skin soft and comfortable.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Which ingredients make this cream a good fit for mature skin?

This cream is a great fit for mature skin because it contains Palmitoyl Tripeptide-5 and Acetyl Hexapeptide-8, which help smooth out fine lines and wrinkles by supporting collagen and relaxing facial tension. It also includes Sodium Hyaluronate and Ceramide Ap to deliver essential hydration and keep your skin barrier strong.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Palmitoyl Tripeptide-1 do for mature skin?

Palmitoyl tripeptide-1 helps improve firmness, smooths out wrinkles, and enhances skin brightness when used as part of an anti-aging routine. Studies show that when applied at night or combined with complementary peptides, it supports collagen production to make mature skin look more firm and elastic.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/)

### What does Argireline do for mature skin?

Argireline helps smooth out lines and makes mature skin look firmer and less rough when used twice a day. It may also help keep skin hydrated, though its penetration is naturally limited.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Where does this cream go in a skincare routine for mature skin?

This moisturizing treatment goes in the evening routine after cleansing and before your final moisturizer, or as your morning moisturizer before sunscreen. It is a great fit for mature skin because it targets fine lines and provides deep hydration and barrier support.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this cream with retinol, and in what order?

Yes, you can use this cream with retinol by applying the retinol first and following it with this moisturizer to help keep your skin comfortable and protected against dryness. Using a barrier-supporting moisturizer alongside retinol helps improve your skin tolerability and supports your overall routine.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

Use this cream twice a day to help improve fine lines and keep mature skin hydrated and smooth. Regular daily application supports the skin barrier and provides noticeable anti-aging benefits over time.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin, as it contains no harsh ingredients and features a safe formulation. It focuses on smoothing fine lines and providing hydration without heavy, pore-blocking agents.

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment on your body and carefully around the eyes, where the skin is particularly thin. Its hydrating ingredients like Sodium Hyaluronate and peptides help smooth fine lines while keeping these delicate areas comfortable.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/ie/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/mature-skin) — Superior fit — €17.84 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/ie/p/cosrx/advanced-snail-96-mucin-power-essence/for/mature-skin) — Superior fit — €14.07 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/ie/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/mature-skin) — Superior fit — €18.99 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ie/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €56.86 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ie/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.28 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ie/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — €26.27 at Amazon

## Where to buy

No store in Ireland has a checked price for this product, so the page shows none.

## Ingredients

Water, Jojoba Seed Oil, Glycerin, Carbomer, Phenoxyethanol, Dimethicone, Prunus Amygdalus Dulcis Oil, Triethanolamine, Sodium Polyacrylate, Butylene Glycol, Dimethiconol, Sodium Lauroyl Lactylate, Diethanolamine, Laureth-4, Laureth-23, Sodium Hyaluronate, Ceramide Np, Palmitoyl Tripeptide-5, Caprylyl Glycol, Polysorbate 20, Phytosphingosine, Cholesterol, Ceramide Ap, Potassium Sorbate, Xanthan Gum, Tocopherol, Hexylene Glycol, Dextran, Acetyl Hexapeptide-8, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide Eop
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/miamimd/age-defying-lift-and-firm-cream/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/miamimd/age-defying-lift-and-firm-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/miamimd/age-defying-lift-and-firm-cream/for/mature-skin (this page)
- Germany: https://lovi.care/skincare/de/p/miamimd/age-defying-lift-and-firm-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/miamimd/age-defying-lift-and-firm-cream/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/miamimd/age-defying-lift-and-firm-cream/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/miamimd/age-defying-lift-and-firm-cream/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/miamimd/age-defying-lift-and-firm-cream/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/miamimd/age-defying-lift-and-firm-cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/miamimd/age-defying-lift-and-firm-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/miamimd/age-defying-lift-and-firm-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/miamimd/age-defying-lift-and-firm-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/miamimd/age-defying-lift-and-firm-cream/for/mature-skin