# Medik8 Oxy-R Peptides for dry sensitive skin

**Lovi Fit: High fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ie/p/medik8/oxy-r-peptides/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Brand: [Medik8](https://lovi.care/skincare/ie/brands/medik8)
Category: [Serums and treatments](https://lovi.care/skincare/ie/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry sensitive skin; a few serums fit it even better.

## Why this fit

- Offers excellent skin brightening for you due to Hydroxyresveratrol and Tetrapeptide-30, which promote evening skin tone and address your dry or flaky skin concerns.
- Provides moderate hydration for your dry skin with Sodium Hyaluronate and Glycerin, while Gluconolactone and Lactic Acid offer mild exfoliation to improve texture.
- The formula is safe for your dry and sensitive skin, containing soothing ingredients and lacking harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ie/p/medik8/oxy-r-peptides/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ie/p/medik8/oxy-r-peptides/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ie/p/medik8/oxy-r-peptides/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ie/p/medik8/oxy-r-peptides/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ie/p/medik8/oxy-r-peptides/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ie/p/medik8/oxy-r-peptides/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ie/p/medik8/oxy-r-peptides/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/ie/p/medik8/oxy-r-peptides/for/dry-sensitive-skin): High (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/ie/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin): High

## Key ingredients

Oxyresveratrol, Peptides, Sodium Hyaluronate, Lactic Acid, Glycerin

## What the research says

- Application of a new brightening complex cream containing niacinamide, tranexamic acid, oxyresveratrol, glutathione disulfide, and linoleic acid for 12 weeks increased skin lightness (L*-value) and significantly decreased melanin index and erythema index in Korean women. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28512843/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Combining 10% gluconolactone chemical peeling with oxybrasion or microneedle mesotherapy increased skin hydration and decreased sebum, pH, and TEWL in twenty-one Caucasian women, with no significant differences between the two methods. ([Skin Research and Technology, 2023](https://pubmed.ncbi.nlm.nih.gov/37357656/))
- Topical application of mulberroside A, oxyresveratrol, and oxyresveratrol-3-O-glucoside reduced UVB-induced skin pigmentation and melanogenic enzyme expression in brown guinea pigs compared to vehicle control, with oxyresveratrol showing the greatest effect. ([Food and Chemical Toxicology, 2011](https://pubmed.ncbi.nlm.nih.gov/21946069/))
- Topical oxyresveratrol microemulsion at 20-30% w/w effectively delayed skin lesion development and protected mice from death compared to untreated controls. ([AAPS PharmSciTech, 2012](https://pubmed.ncbi.nlm.nih.gov/22996670/))
- Encapsulating dihydrooxyresveratrol and oxyresveratrol into nanostructured lipid carriers enhanced photostability, promoted controlled release, facilitated skin penetration, exhibited no cytotoxicity up to 500 µg/mL on human keratinocytes, and effectively reduced melanogenesis in B16F10 cells. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39587280/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, users with hyperpigmentation, melasma, and post-inflammatory erythema (PIE) frequently report visible skin brightening and the fading of dark spots, often noting a smoother texture and "glass-like" glow within weeks. While many experience rapid results, a minority of users report no visible changes or mild breakouts, and the short shelf life of the activated formula is a noted consideration.

- Liked: Fades dark spots (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Gentle formulation (sometimes noted)
- Liked: Rapid results (sometimes noted)
- Disliked: Ineffective for some (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Short shelf life (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medik8 Oxy-R Peptides a great fit for dry sensitive skin?

Medik8 Oxy-R Peptides is a great fit for your dry sensitive skin because it brightens your complexion while gently smoothing dry or flaky patches with mild exfoliants. It also delivers helpful hydration and a safe formula that avoids harsh ingredients. Ingredients like hyaluronic acid and glycerin support this comfort by boosting skin moisture.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry sensitive skin?

Sodium Hyaluronate and Glycerin make this serum a good fit by providing moderate hydration for your dry skin, while Gluconolactone and Lactic Acid offer mild exfoliation to improve texture. Additionally, Hydroxyresveratrol and Tetrapeptide-30 help brighten your skin tone and address dry or flaky skin concerns safely.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Oxyresveratrol do for dry sensitive skin?

Oxyresveratrol helps brighten skin and may even out your tone when used in a complex cream. Because it can be active on delicate areas, dry sensitive skin needs soothing ingredients and gentle moisturizers to keep skin calm and soft.
Sources: [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28512843/)

### What do Peptides do for dry sensitive skin?

Peptides help hydrate dry sensitive skin while smoothing the look of fine lines and keeping the surface calm. They may also improve skin elasticity, though some types need enhanced delivery systems to deeply penetrate the skin barrier.
Sources: [Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40565185/)

### Where does it go in a skincare routine for dry sensitive skin?

This treatment goes in your evening routine, applied after your toner and before your moisturizer. Starting it just once a week is best for your dry and sensitive skin, and you can slowly use it more often if your skin handles it well.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment in your evening routine after cleansing and toning, and following it with a moisturizer. Because retinol and exfoliating ingredients can sometimes dry out sensitive skin, alternating nights or watching how your skin responds helps prevent irritation.

### How often should I use it?

Start using this treatment once a week in the evening, and if your dry and sensitive skin handles it well, you may carefully use it more often. The formula safely brightens your skin tone and gently smooths texture while providing moderate hydration.

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to cause breakouts or clog pores for your dry sensitive skin, as it has a very low rate of such complaints and includes gentle, soothing ingredients. The formula also provides mild exfoliation with lactic acid and gluconolactone to help keep pores clear without harshness.
Sources: [Skin Research and Technology, 2023](https://pubmed.ncbi.nlm.nih.gov/37357656/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ie/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — €185.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/ie/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-sensitive-skin) — Superior fit — €14.94 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/ie/p/augustinus-bader/the-serum/for/dry-sensitive-skin) — Superior fit — €385.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/ie/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — €14.68 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/ie/p/pixi/milky-tonic/for/dry-sensitive-skin) — Superior fit — €27.17 at Amazon
- Moisturizer with Sun Protection: [Dr.G Green Mild Up Sun+](https://lovi.care/skincare/ie/p/dr-g/green-mild-up-sun/for/dry-sensitive-skin) — Superior fit — €23.00 at Amazon

## Where to buy

- Notino: €81.40 (https://www.notino.ie/medik8/oxy-r-peptides-intensive-serum-with-peptides/p-16151739/)
Prices checked 26 Oct 2026.

## Ingredients

Water, Butylene Glycol, Artocarpus Lakoocha Extract Wood, Hydroxyresveratrol, Gluconolactone, Acetyl Glycyl Beta-Alanine, Glycerin, Lactic Acid, Sodium Hyaluronate, Sodium Benzoate, Disodium Edta, Tetrapeptide-30, Xanthan Gum, Sodium Metabisulfite, Calcium Gluconate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medik8/oxy-r-peptides/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medik8/oxy-r-peptides/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/medik8/oxy-r-peptides/for/dry-sensitive-skin (this page)
- Germany: https://lovi.care/skincare/de/p/medik8/oxy-r-peptides/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/medik8/oxy-r-peptides/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/medik8/oxy-r-peptides/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/medik8/oxy-r-peptides/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/medik8/oxy-r-peptides/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/medik8/oxy-r-peptides/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/medik8/oxy-r-peptides/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/medik8/oxy-r-peptides/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medik8/oxy-r-peptides/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medik8/oxy-r-peptides/for/dry-sensitive-skin