# Medicube Zero Exosome Shot for dry sensitive skin

**Lovi Fit: Average fit for dry sensitive skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ie/p/medicube/zero-exosome-shot/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Brand: [Medicube](https://lovi.care/skincare/ie/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/ie/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your dry skin, as glycerin and panthenol provide humectant action, while niacinamide and gluconolactone help even skin tone and smooth texture.
- While the formula offers general skincare benefits, it lacks specialized ingredients like ceramides or hyaluronic acid in concentrations that would optimally support your dry or flaky skin and sensitivity.
- The product is safe for your dry and sensitive skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ie/p/medicube/zero-exosome-shot/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ie/p/medicube/zero-exosome-shot/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ie/p/medicube/zero-exosome-shot/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ie/p/medicube/zero-exosome-shot/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ie/p/medicube/zero-exosome-shot/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ie/p/medicube/zero-exosome-shot/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ie/p/medicube/zero-exosome-shot/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ie/p/medicube/zero-exosome-shot/for/dry-sensitive-skin): Average (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/ie/p/medicube/zero-exosome-shot/for/oily-acne-prone-skin): High

## Key ingredients

Lacto Exosome, Niacinamide, Betaine Salicylate, Adenosine, Hydrolyzed Sponge

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Lactobacillus-derived exosome therapy combined with microneedling reduced acne severity, post-inflammatory hyperpigmentation, and atrophic scarring in three patients, with high satisfaction and minimal adverse effects. ([The Journal of Craniofacial Surgery, 2025](https://pubmed.ncbi.nlm.nih.gov/40257450/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- A nano-encapsulated spicule system delivering Wharton's Jelly MSC secretome enhanced transdermal penetration, promoted cell proliferation and collagen synthesis in vitro, and reduced wrinkles and pigmentation in clinical evaluation. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41155317/))
- Deer antler velvet extract formulated in sponge spicule micro-blend cream applied to healthy humans for 14 days enhanced macromolecule skin permeation by 1.94-fold, decreased melanin content and erythema, and increased skin elasticity and hydration without causing irritation. ([Biological & Pharmaceutical Bulletin, 2019](https://pubmed.ncbi.nlm.nih.gov/31257296/))
- Marine sponge spicules enhanced the skin delivery of human umbilical cord-derived mesenchymal stem cell exosomes by a factor of 5.87 and combined with them produced significant anti-photoaging effects in mice compared to exosomes alone. ([International Journal of Nanomedicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32368058/))

## Why other serums fit dry sensitive skin better

- Tocopherol succinate-loaded ethosomal gel increased skin deposition, stability, moisture, and mechanical properties in 13 human subjects compared to a control gel over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35274433/))
- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle. ([Skin Pharmacology and Physiology, 2026](https://pubmed.ncbi.nlm.nih.gov/41758783/))

## What reviewers say

Users describe this ampoule as a potent texturizing treatment that delivers a glass skin finish by minimizing pores and smoothing roughness. While highly effective for many in tightening pores and boosting radiance, the sensation is polarizing, often described as a prickly or tingling feeling that can be intense for sensitive skin.

- Liked: Smoother texture (mostly mentioned)
- Disliked: Prickly sensation (mostly mentioned)
- Liked: Pore minimization (often mentioned)
- Liked: Radiance and glow (often mentioned)
- Liked: Enhanced absorption (sometimes noted)
- Disliked: Skin irritation (sometimes noted)
- Disliked: Lack of results (rarely noted)
- Disliked: Unpleasant texture (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does the Zero Exosome Shot work for dry sensitive skin?

The MEDICUBE Zero Exosome Shot works reasonably well for dry sensitive skin, as glycerin and panthenol pull in moisture while niacinamide helps smooth texture. It is safe for sensitive skin, but a product of this type needs specialized ingredients like ceramides or hyaluronic acid to properly target dryness and flakiness.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this serum a good fit for dry sensitive skin?

Glycerin and panthenol make this serum a good fit because they draw moisture into dry skin and help calm irritation. Niacinamide and gluconolactone also help even out skin tone and smooth texture safely.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Lacto Exosome do for dry sensitive skin?

Lacto Exosome helps strengthen dry sensitive skin by supporting the skin barrier so it holds onto moisture better. It does this by boosting key proteins that keep the skin smooth and resilient.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40356846/)

### What does Niacinamide do for dry sensitive skin?

Niacinamide helps dry sensitive skin by calming irritation and keeping moisture locked in so your face feels soft and smooth. It works to build up your skin barrier and calm redness while being very gentle and unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [International Journal of Pharmaceutics, 2013](https://pubmed.ncbi.nlm.nih.gov/23220080/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This treatment goes in your evening routine after your soothing toner and before your moisturizer. A dry skin routine needs rich hydrators like ceramides or hyaluronic acid to properly support and comfort dry or flaky skin.

### Can I use this serum with retinol, and in what order?

This treatment is safe for your dry and sensitive skin, but since it lacks strong moisture-locking ingredients, this skin type needs added ceramides or hyaluronic acid to stay comfortable alongside strong products like retinol.

### How often should I use this serum?

Start by using this treatment once a week in your evening routine, and if your skin tolerates it well without irritation, you may carefully use it more often. This product works for your dry sensitive skin, but to truly support dryness and flakiness, a product of this type needs rich moisturizing ingredients like ceramides or hyaluronic acid.

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This treatment is unlikely to clog pores or cause breakouts for your dry sensitive skin, as its safe formula lacks harsh ingredients. However, to truly comfort dry or flaky skin, a product of this type needs rich moisture-locking ingredients and barrier-repairing ceramides or hyaluronic acid.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ie/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — €185.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/ie/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-sensitive-skin) — Superior fit — €14.94 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/ie/p/augustinus-bader/the-serum/for/dry-sensitive-skin) — Superior fit — €385.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/ie/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — €14.68 at Amazon
- Soothing Toner: [Pixi Milky Tonic](https://lovi.care/skincare/ie/p/pixi/milky-tonic/for/dry-sensitive-skin) — Superior fit — €27.17 at Amazon
- Moisturizer with Sun Protection: [Dr.G Green Mild Up Sun+](https://lovi.care/skincare/ie/p/dr-g/green-mild-up-sun/for/dry-sensitive-skin) — Superior fit — €23.00 at Amazon

## Where to buy

- Amazon.ie: €23.25 (https://www.amazon.ie/dp/B0D137TMRB?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, Butylene Glycol, 1,2-Hexanediol, Niacinamide, Sodium Polyacrylate, Ethylhexyl Palmitate, Hydrolyzed Sponge, C12-14 Alketh-12, Hydrogenated Polydecene, Ethylhexylglycerin, Adenosine, Caprylyl Capryl Glucoside, Disodium Edta, Panthenol, Calcium Silicate, Lactobacillus Extracellular Vesicles, Campsis Grandiflora Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Oenothera Biennis Flower Extract, Ulmus Davidiana Root Extract, Sodium Silicate, Betaine Salicylate, Citric Acid, Gluconolactone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/zero-exosome-shot/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/zero-exosome-shot/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/zero-exosome-shot/for/dry-sensitive-skin (this page)
- Germany: https://lovi.care/skincare/de/p/medicube/zero-exosome-shot/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/medicube/zero-exosome-shot/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/medicube/zero-exosome-shot/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/zero-exosome-shot/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/medicube/zero-exosome-shot/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/zero-exosome-shot/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/medicube/zero-exosome-shot/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/zero-exosome-shot/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/zero-exosome-shot/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/zero-exosome-shot/for/dry-sensitive-skin