Medi-Peel Peptide 9 Hyaluronic Volumy Eye Cream for skin with dark spots

Questions and answers

What the research says

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated.

  Antioxidants, 2021

• Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide.

  Advanced Science, 2025

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

• Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality.

  Archives of Facial Plastic Surgery, 2006

• A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days.

  Cureus, 2024

• The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls.

  Skin Research and Technology, 2026

Why other eye cares fit skin with dark spots better

• Bakuchiol functions as an anti-aging compound through retinol-like regulation of gene expression, producing significant improvements in lines, wrinkles, pigmentation, elasticity, firmness, and photo-damage after 12 weeks of twice-a-day facial application without usual retinol therapy-associated undesirable effects.

  International Journal of Cosmetic Science, 2014

• Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.

  The British Journal of Dermatology, 2019

• Topical application of a water-in-oil emulsion containing 2% Muscat hamburg grape seed extract significantly improved melanin, elasticity, and sebum content compared to a placebo in human volunteers over 8 weeks, with no reported skin hypersensitivity.

  International Journal of Cosmetic Science, 2015

Ingredients

Water, Methylpropanediol, Caprylic Capric Triglyceride, Glycerin, Dimethicone, Niacinamide, Pentaerythrityl Tetraisostearate, Cyclopentasiloxane, Cetearyl Alcohol, Cetearyl Olivate, Cyclohexasiloxane, Sorbitan Olivate, Glyceryl Stearate, Butyrospermum Parkii Butter Shea Butter, Hydroxypropylmethyl Cellulose, Peg-100 Stearate, Pullulan, Hydroxyacetophenone, Helianthus Annuus Seed Oil Sunflower Seed Oil, Sodium Polyacrylate, Arginine, Carbomer, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Cetearyl Glucoside, Isohexadecane, Juniperus Communis Fruit Extract, Eucalyptus Globulus Leaf Extract, Trehalose, Ethylhexylglycerin, Xanthan Gum, Polysorbate 80, Porphyridium Cruentum Extract, Glycine Soja Oil Soybean Oil, Adenosine, Malt Extract, Sodium Hyaluronate, Disodium Edta, Sorbitan Oleate, Propanediol, Sodium Hyaluronate Crosspolymer, Bixa Orellana Seed Oil, Hydrolyzed Glycosaminoglycans, Olea Europaea Leaf Extract Olive Leaf Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Dandelion Leaf Extract, Magnolia Officinalis Bark Extract, Fructan, Hydrolyzed Elastin, Hydrolyzed Collagen, Hydrogenated Polyisobutene, Benzyl Glycol, Tocopherol, Propylene Glycol, Rosa Damascena Flower Extract, Rhodiola Rosea Root Extract, Hydrolyzed Hyaluronic Acid, Ginkgo Biloba Leaf Extract, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Butylene Glycol, 1,2-Hexanediol, Raspberry Ketone, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Anemarrhena Asphodeloides Root Extract, Acetyl Hexapeptide-8, Copper Tripeptide-1, Palmitoyl Oligopeptide, Palmitoyl Tripeptide-1, Oligopeptide-29, Oligopeptide-32, Palmitoyl Pentapeptide-4

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.