🇮🇪Ireland

Lancôme Rénergie H.P.N. 300-Peptide Cream for oily acne-prone skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Lancôme Rénergie H.P.N. 300-Peptide Cream

Average

  • AverageOily Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for oily acne-prone skin; other moisturizers fit it better.

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate suitability for your oily skin due to the presence of niacinamide which offers seboregulation, but lacks sufficient ingredients for optimal oil control.
  • The product provides excellent moisturizing and anti-aging effects with hydrolyzed hyaluronic acid and adenosine, which hydrate and smooth texture, but these are mostly supportive for your acne, blemishes, and breakouts.
  • The safety profile is good, with no risks of irritation for your oily skin due to the absence of harsh ingredients and the presence of soothing ingredients like Tocopherol.

How to apply

  • Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
  • Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
  • Gently press a small amount into your skin and avoid rubbing to keep pores clear.
  • Apply on clean, slightly damp skin to help the product absorb better and control oil.
  • Avoid the sensitive eye area and do a simple patch test before your first use.

People Say

★4.7Overall rating based on 7.1k+ reviews

Based on a very large amount of data, this rich cream is highly recommended for mature and dry skin, effectively plumping, firming, and smoothing without greasiness, leading to a radiant complexion. Some users noted sensitivity to the fragrance and found the price to be high.

Highlights

  • Luxurious non-greasy texture Mostly Mentioned
    • “rich cream that absorbs instantly”
    • “feels like butter but not oily”
    • “sinks in beautifully”
    • “perfect under makeup”
  • Deep hydration Often Mentioned
    • “skin feels hydrated all day”
    • “no more dry patches”
    • “leaves face feeling soft”
    • “plumps up dehydration lines”
  • Visible anti-aging results Often Mentioned
    • “jawline looks tighter”
    • “fine lines are less visible”
    • “skin feels plumper”
    • “texture is much smoother”
  • High price point Often Mentioned
    • “very expensive for the amount”
    • “hard to justify the cost”
    • “price is a bit steep”
    • “wish it was more affordable”
  • Pleasant fragrance Sometimes Noted
    • “smells absolutely divine”
    • “light and fresh scent”
    • “fragrance is lovely but not overpowering”
    • “luxurious spa smell”
  • Refillable packaging Sometimes Noted
    • “love that it is refillable”
    • “beautiful heavy glass jar”
    • “great sustainable option”
    • “easy to replace the pod”
  • Heavy for oily skin Rarely Noted
    • “too heavy for my oily zone”
    • “made me look greasy”
    • “clogged my pores”
    • “better for night use only”
  • Lack of dramatic results Rarely Noted
    • “didn't see a difference”
    • “just a basic moisturizer”
    • “not enough for very dry skin”
    • “expected more for the price”
  • Skin irritation Rarely Noted
    • “caused a red rash”
    • “skin felt burning”
    • “broke me out in hives”
    • “irritated my sensitive skin”
  • Strong fragrance Rarely Noted
    • “fragrance is too heavy”
    • “smell lingers too long”
    • “perfume irritated my eyes”
    • “wish it was fragrance-free”

Sources: lovi.care, macys.com, ulta.com, lancome-usa.com, walmart.com, sephora.com, and more

Questions and answers

How well does Lancôme Rénergie H.P.N. 300-Peptide Cream work for oily acne-prone skin?

This cream works moderately well for oily acne-prone skin because it contains niacinamide to help balance oil, but it lacks enough ingredients for strong oil control. While it hydrates and smooths your skin texture, it needs lightweight ingredients that control excess oil and clear breakouts without clogging pores.

Which ingredients make this cream a good fit for oily acne-prone skin?

This cream is an average fit for your oily acne-prone skin because niacinamide helps balance oil, while tocopherol provides soothing benefits. To work better for this skin, a product of this type needs lightweight hydrators and ingredients that manage breakouts without adding heaviness.

What do Peptides do for oily acne-prone skin?

Peptides help calm oily, acne-prone skin by targeting acne-causing bacteria and reducing redness and swelling. Advanced delivery methods like nanomicelles may also improve how deeply these helpful ingredients sink into the skin.

Advanced Science, 2025Bioorganic Chemistry, 2025

What does Hyaluronic Acid do for oily acne-prone skin?

Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.

The Journal of Investigative Dermatology, 2017Journal of Cosmetic Dermatology, 2022

Where does this cream go in a skincare routine for oily acne-prone skin?

This moisturizing treatment goes after your cleanser, hydrating toner, and treatment in the evening, and after your cleanser and hydrating toner in the morning. Oily acne-prone skin needs a product of this type to include targeted ingredients for oil control and blemishes.

Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying the treatment first and following with the moisturizer. This combination helps keep your skin hydrated and may reduce the irritation often caused by retinol. To properly suit oily acne-prone skin, a product of this type needs specialized oil-controlling ingredients and lightweight, non-greasy hydrators.

Cutis, 2006The Journal of Dermatology, 2014

How often should I use this cream?

This cream works for your oily acne-prone skin with moderate suitability, and you can use it daily as part of your regular moisturizing routine. Twice-daily application helps improve hydration and texture, though this type of skin needs extra oil-control ingredients and targeted blemish treatments for best results.

Journal of Cosmetic Dermatology, 2020Journal of Drugs in Dermatology, 2015

Can this cream clog pores, cause breakouts or purging for oily acne-prone skin?

This cream is unlikely to cause irritation or breakouts on your oily skin due to the soothing ingredients like Tocopherol and the absence of harsh ingredients. However, oily acne-prone skin needs a product with stronger oil control ingredients to keep pores clear.

Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes or on your body, but it is primarily formulated as a facial product. Since the skin around the eyes is much thinner than the skin on most other body regions, rich facial creams may feel heavy there, though this formula has a good safety profile with soothing ingredients that are unlikely to cause irritation.

Surgical and Radiologic Anatomy, 2002

Is this cream fragrance-free and alcohol-free?

It contains fragrance (benzyl alcohol, geraniol, limonene, and parfum) and drying alcohol (alcohol denat).

What the research says

  • Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects.

    International Journal of Cosmetic Science, 2018

  • Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events.

    Journal of Cosmetic Dermatology, 2019

  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011

  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022

  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

  • Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

    Journal of Cosmetic Dermatology, 2021

  • Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

    The Journal of Investigative Dermatology, 2008

  • Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

    Dermatologic Surgery, 2005

  • Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.

    The Journal of Dermatology, 2008

  • Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.

    International Journal of Molecular Sciences, 2026

  • Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.

    International Journal of Molecular Sciences, 2021

Why other moisturizers fit oily acne-prone skin better

  • A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.

    Journal of Cosmetic Dermatology, 2024

  • A peel-off facial mask containing myoinositol and trehalose-loaded liposomes improved adult female acne by decreasing lesion counts, sebum production, GAGS scores, and local androgen levels while increasing beclin-1 levels.

    Journal of Cosmetic Dermatology, 2017

  • Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

    Molecules, 2023

Ingredients

Water, Glycerin, Dimethicone, Cetearyl Alcohol, Theobroma Grandiflorum Seed Butter, Alcohol Denat, Cetearyl Isononanoate, Niacinamide, Glyceryl Stearate, Peg-100 Stearate, Isopropyl Palmitate, Octyldodecanol, Cyclodextrin, Hydrolyzed Lupine Protein, Pisum Sativum Extract, Adenosine, Capryloyl Salicylic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Linseed Extract, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Trisodium Ethylenediamine Disuccinate, Tocopheryl Acetate, Alba Cera, Beeswax, Cire Dabeille, Orbignya Oleifera Seed Oil, Jojoba Butter, Cetearyl Glucoside, Citric Acid, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysorbate 60, Potassium Cetyl Phosphate, Sorbitan Isostearate, Tocopherol, Dimethicone Polyglycerin-3 Crosspolymer, Benzyl Alcohol, Geraniol, Limonene, Chlorphenesin, Dipropylene Glycol, Phenoxyethanol, Sodium Benzoate, Parfum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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Prices checked 10 Oct – 5 Nov 2026

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
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