La Mer Genaissance de la Mer The Infused Lotion for mature skin

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.

  American Journal of Clinical Dermatology, 2013

• Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.

  Journal of Cosmetic and Laser Therapy, 2013

• Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.

  Annals of Dermatology, 2019

• Bog blueberry anthocyanin-rich extract attenuated ultraviolet-B-induced toxicity, DNA damage, collagen degradation, and inflammatory cytokine release in human dermal fibroblasts by modulating NF-kappaB and MAPK signaling pathways.

  Molecular Nutrition & Food Research, 2009

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Treatment with lipid algae extract reduced the level of oxidized proteins in human keratinocytes and stratum corneum skin cells.

  Annals of the New York Academy of Sciences, 2004

• Topical astaxanthin-loaded algae extract hydrogel and lipogel formulations exhibited the highest antioxidant activity and successful in vitro release, suggesting their potential as anti-aging formulations.

  Journal of Cosmetic Dermatology, 2019

• Antarctic marine algae extracts increased cell viability, protected against inflammation, and enhanced the barrier integrity of human intestinal and keratinocyte cell lines damaged by lipopolysaccharide or ultraviolet radiation.

  Marine Drugs, 2022

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

Ingredients

Water, Dimethicone, Methyl Trimethicone, Isododecane, Phenyl Trimethicone, Polysilicone-11, Squalane, Glycerin, Glycereth-26, Propanediol, Algae Extract, Sesamum Indicum Seed Oil, Medicago Sativa Seed Powder, Helianthus Annuus Seedcake Sunflower Seedcake, Prunus Amygdalus Dulcis Seed Meal Seed, Eucalyptus Globulus Oil Leaf Eucalyptus Oil Leaf, Sodium Gluconate, Copper Gluconate, Calcium Gluconate, Magnesium Gluconate, Zinc Gluconate, Tocopheryl Succinate, Niacin, Sesamum Indicum Seed Powder, Sapindus Mukorossi Fruit Extract, Linoleic Acid, Garcinia Mangostana Peel Extract, Citrus Aurantifolia Peel Extract, Helichrysum Italicum Extract, Laminaria Digitata Extract, Cranberry Fruit Extract, Blueberry Fruit Extract, Lycium Chinense Fruit Extract Wolfberry Fruit Extract, Whey Lactis Proteine Du Petit-Lait Protein, Jania Rubens Extract, Yeast Faex Extrait De Levure Extract, Citrus Reticulata Peel Extract Tangerine Peel Extract, Cladosiphon Okamuranus Extract, Sucrose, Bis-Stearyl Dimethicone, Cetyl Dimethicone, Persea Gratissima Oil Avocado Oil, Caffeine, Chondrus Crispus, Lactobacillus Ferment, Yeast Polysaccharides, Sodium Hyaluronate, Trehalose, Acetyl Hexapeptide-8, Caprylic Capric Triglyceride, Isononyl Isononanoate, Acetyl Glucosamine, Triolein, Phytosteryl Canola Glycerides, Hydrolyzed Wheat Protein, Caesalpinia Spinosa Gum, Tourmaline, Peg-40 Hydrogenated Castor Oil, Gold, Peg-75, Butylene Glycol, Ethylhexyl Isononanoate, Caprylyl Glycol, Saccharide Isomerate, Peg-7m, Dextrin, Tocopheryl Acetate, Tetrahexyldecyl Ascorbate, Citric Acid, Sodium Hydroxide, Maltodextrin, Hexylene Glycol, Oleic Acid, Palmitic Acid, Stearic Acid, Polymethylsilsesquioxane, Alcohol Denat, Vinyl Dimethicone Methicone Silsesquioxane Crosspolymer, Parfum, Trimethylsiloxysilicate, Disodium Edta, Bht, Sodium Benzoate, Chlorphenesin, Phenoxyethanol, Linalool, Citronellol, Geraniol, Hydroxycitronellal, Limonene, Red 4 Ci 14700

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.