# iS Clinical Hydra-Cool Serum for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ie/p/is-clinical/hydra-cool-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Brand: [iS Clinical](https://lovi.care/skincare/ie/brands/is-clinical)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ie/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate hydration and soothing benefits for your acne, blemishes, and breakouts due to the presence of sodium hyaluronate and asiaticoside, which provide general skincare benefits.
- This serum is highly suitable for your combination skin, as sodium hyaluronate and pantothenic acid offer humectant action and barrier repair.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of prohibited or harsh ingredients and the presence of soothing ingredients like menthol and asiaticoside.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ie/p/is-clinical/hydra-cool-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ie/p/is-clinical/hydra-cool-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ie/p/is-clinical/hydra-cool-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ie/p/is-clinical/hydra-cool-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ie/p/is-clinical/hydra-cool-serum/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/ie/p/is-clinical/hydra-cool-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ie/p/is-clinical/hydra-cool-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ie/p/is-clinical/hydra-cool-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ie/p/is-clinical/hydra-cool-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Asiaticoside, Madecassic Acid, Menthol, Pantothenic Acid

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Cooling skin temperature or applying topical menthol reduced histamine-induced itch intensity and flare diameters in healthy male volunteers. ([Neuroscience Letters, 1995](https://pubmed.ncbi.nlm.nih.gov/7624016/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Coadministration of 40% topical L-menthol with 10% trans-cinnamaldehyde reduced spontaneous pain intensity, neurogenic inflammation, primary and secondary mechanical hyperalgesia, and heat hyperalgesia, but not cold hyperalgesia, in 14 healthy volunteers. ([The Journal of Pain, 2016](https://pubmed.ncbi.nlm.nih.gov/27260636/))
- Topical application of menthol-based cooling gel decreased intramuscular temperature by 1.9 °C and increased cutaneous blood flow by 0.3 ml/min in healthy males compared to placebo gel. ([International Journal of Sports Physical Therapy, 2018](https://pubmed.ncbi.nlm.nih.gov/30038834/))
- Topical L-menthol and trans-cinnamaldehyde administered individually and in combination on the volar forearm of healthy volunteers induced distinct somatosensory and vasomotor effects, where L-menthol reduced the axon-reflex-flare and altered the mechanical hyperalgesia caused by trans-cinnamaldehyde. ([European Journal of Pain, 2014](https://pubmed.ncbi.nlm.nih.gov/24664788/))
- Panthenyl triacetate (PTA) demonstrated skin de-acetylation into panthenol, stimulated energetic and synthesis metabolic pathways, and achieved a statistically significant improvement in wound healing after 72 hours compared to saline treatment in human volunteers, outperforming panthenol in long-lasting wound healing action. ([Journal of Cosmetic Science, 2012](https://pubmed.ncbi.nlm.nih.gov/22487447/))
- A comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol following PicoWay laser treatment decreased transepidermal water loss, increased hydration and skin elasticity, reduced wrinkles and redness, and improved skin tone in 88 Chinese females compared to a standard care control group. ([Lasers in Medical Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42686896/))
- Formulations containing 1.0% and 5.0% panthenol decreased transepidermal water loss after 30-day applications on healthy subjects compared to control and vehicle. ([Journal of Cosmetic Science, 2011](https://pubmed.ncbi.nlm.nih.gov/21982351/))

## What reviewers say

This serum is widely praised as a "drink of water" for the skin, excelling at soothing irritation, redness, and sunburns while providing lightweight hydration. It is particularly favored by users with acne-prone and sensitive skin for its ability to calm inflammation without clogging pores, though some find it insufficient for extremely dry skin types.

- Liked: Soothing & Cooling (mostly mentioned)
- Liked: Lightweight Hydration (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Acne-Safe (sometimes noted)
- Liked: Versatile Use (sometimes noted)
- Disliked: Insufficient moisture (rarely noted)
- Disliked: Menthol sensitivity (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does iS Clinical Hydra-Cool work for acne-prone skin?

iS Clinical Hydra-Cool Serum works for acne-prone skin, though other products fit it better because they contain ingredients like niacinamide, peptides, and hydrolyzed hyaluronic acid that provide stronger hydration and better care for breakouts without causing excess oiliness.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this serum a good fit for acne-prone skin?

Sodium hyaluronate, asiaticoside, and pantothenic acid make this serum a good fit for acne-prone skin by offering moderate hydration and soothing benefits. To fit this skin even better, products of this type need ingredients like niacinamide and hydrolyzed hyaluronic acid for optimal moisture without excess oiliness.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### What does Asiaticoside do for acne-prone skin?

Asiaticoside helps calm acne-prone skin and supports healing by acting on the biological pathways involved in skin inflammation and blemishes. It works best when paired with soothing ingredients and gentle hydration to keep the skin barrier balanced without irritation.
Sources: [Evidence-based Complementary and Alternative Medicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34845411/)

### Where does it go in a skincare routine for acne-prone skin?

This serum goes in your evening routine after cleansing and before moisturizing, though some people can also use it in the morning. An acne-prone skin type needs a product that provides targeted blemish control ingredients and oil-balancing benefits.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to give your skin moisture and help calm any irritation before adding your retinol product. This type of routine works best for acne-prone skin when it also includes targeted ingredients that deeply clear pores and gently control breakouts.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use it?

You can use this treatment in your evening routine for simplicity and extra safety around sun exposure. This product works for your acne-prone skin, though acne-prone skin needs a product that delivers targeted blemish-fighting ingredients alongside lightweight hydration.

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to clog pores or cause breakouts for acne-prone skin because it avoids harsh ingredients and features soothing components that calm the skin. Acne-prone skin still benefits most from a moisturizing treatment that offers targeted oil control and powerful blemish-clearing ingredients.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can I use it around the eyes or on my body?

This serum can be used around the eyes or on the body, as its gentle ingredients are safe for delicate areas. However, because it only offers moderate hydration, acne-prone skin on the body and eyes tends to do better with products that provide deep moisture and targeted spot-clearing ingredients.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/ie/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/acne-prone-skin) — High fit — €32.09 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/ie/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/acne-prone-skin) — High fit — €35.40 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/ie/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin) — Average fit — €21.00 at Notino

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/ie/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.40 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/ie/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €19.99 at Amazon
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/ie/p/d-alba/piedmont-waterfull-mild-sunscreen/for/acne-prone-skin) — Superior fit — €17.43 at Amazon

## Where to buy

No store in Ireland has a checked price for this product, so the page shows none.

## Ingredients

Water, Sodium Hyaluronate, Pantothenic Acid, Pentylene Glycol, Menthol, Phenoxyethanol, Asiaticoside, Polyporus Umbellatus Extract Mushroom Extract, Asiatic Acid, Madecassic Acid, Blue 1 Ci 42090
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/hydra-cool-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/hydra-cool-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/hydra-cool-serum/for/acne-prone-skin (this page)
- Germany: https://lovi.care/skincare/de/p/is-clinical/hydra-cool-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/hydra-cool-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/hydra-cool-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/hydra-cool-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/hydra-cool-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/hydra-cool-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/hydra-cool-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/hydra-cool-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/hydra-cool-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/hydra-cool-serum/for/acne-prone-skin