# IOPE Pro Peeling Enzyme Wash for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Brand: [IOPE](https://lovi.care/skincare/ie/brands/iope)
Category: [Exfoliants](https://lovi.care/skincare/ie/best/exfoliators)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best products for mature skin.

## Why this fit

- Offers excellent cleansing and moderate exfoliation for wrinkles and fine lines, as papain and protease work synergistically to renew the skin, while betaine and squalane provide essential hydration and emollience for your normal skin type.
- The inclusion of lemon fruit extract and saccharum officinarum extract further aids in skin renewal and brightening, complementing the primary exfoliating agents.
- The formula is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin): High

## Key ingredients

Papain, Squalane, Acetyl Glucosamine, Betaine, Vaccinium Myrtillus Fruit Extract

## What the research says

- A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- L-ascorbic acid and betaine-based therapeutic deep eutectic system significantly enhanced transdermal delivery through porcine skin compared to ascorbic acid alone or physical mixture, and reduced aging markers while inducing an even skin tone in humans. ([Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/38794349/))
- Soaps containing betaine caused the least skin irritation compared to other tested soaps in twenty-eight healthy subjects, though irritation did not decrease with increasing concentrations of betaine. ([Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/))
- Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo. ([Wilderness & Environmental Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/26827260/))
- A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face. ([Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/))
- Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation. ([Molecules, 2020](https://pubmed.ncbi.nlm.nih.gov/31991676/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical dry mouth products containing olive oil, betaine, and xylitol significantly increased unstimulated whole salivary flow rates, reduced xerostomia complaints, and improved quality of life in adults with polypharmacy-induced xerostomia compared to their normal routine care, with no clinically significant adverse events. ([Journal of Oral Rehabilitation, 2007](https://pubmed.ncbi.nlm.nih.gov/17824884/))
- Mixed surfactant systems of sodium dodecyl sulfate and dimethyl dodecyl amido betaine significantly reduce acute skin irritation potential in human volunteers compared with the individual surfactants, demonstrating that irritation potential cannot be predicted by simple summation. ([Food and Chemical Toxicology, 1998](https://pubmed.ncbi.nlm.nih.gov/9609395/))
- Polyhexanide/betaine may be nontoxic and effective in enhancing wound healing, whereas the majority of other topical cleaning agents are locally toxic and of limited or no proven efficacy. ([Advances in Skin & Wound Care, 2013](https://pubmed.ncbi.nlm.nih.gov/23507692/))
- Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days. ([Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/))
- Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/))
- Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations. ([Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38247529/))

## What reviewers say

Based on limited data, users find this enzyme wash effectively exfoliates and smooths skin, leaving it feeling soft and clean without dryness, making it suitable for sensitive skin. However, the product is considered expensive for the quantity provided, and the powder format can lead to clumping and dispensing difficulties.

- Liked: Improved skin texture (mostly mentioned)
- Liked: Gentle exfoliation (often mentioned)
- Liked: Non-stripping cleanse (often mentioned)
- Disliked: Expensive for amount (often mentioned)
- Disliked: Packaging issues (often mentioned)
- Liked: Effective deep clean (sometimes noted)
- Disliked: Availability issues (sometimes noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Could be used as part of your PM routine once a week, increasing to 2-3 times if your skin tolerates it well.
- Place this enzyme powder cleanser in your weekly routine after your regular cleanser and before your hydrating toner.
- Mix a small amount of the enzyme powder cleanser with water in your hands to create a soft foam before applying.
- Gently massage the foam onto your damp face using circular motions, then rinse thoroughly with warm water.
- Avoid the sensitive eye area and always apply SPF the morning after using exfoliating products.
- Video: https://storage.pora.ai/2d8db6e67371d665a6a7736b5ed5d762.mp4

## Questions and answers

### What makes IOPE Enzyme Wash one of the best fits for mature skin?

This cleanser is an excellent fit because papain and protease gently renew mature skin to help smooth fine lines and wrinkles. At the same time, squalane and betaine keep your face feeling soft and well-hydrated without causing irritation.
Sources: [Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/), [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/)

### Which ingredients make this cleanser a good fit for mature skin?

Papain and protease help renew mature skin and smooth out fine lines, while betaine and squalane keep normal skin hydrated and soft. Lemon and sugar maple extracts further assist in brightening and renewing the skin safely.
Sources: [Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/), [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/)

### What does Papain do for mature skin?

Papain gently exfoliates the outer layer of skin by breaking down surface proteins, which helps reveal smoother and fresher skin. This gentle shedding process may improve skin texture and reduce the look of dullness in mature skin.
Sources: [International Journal of Cosmetic Science, 2022](https://pubmed.ncbi.nlm.nih.gov/35892222/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34897928/)

### What does Squalane do for mature skin?

Squalane helps keep mature skin feeling soft and smooth by boosting moisture and protecting the skin barrier. It also provides antioxidant support that helps improve the look of fine lines and wrinkles over time.
Sources: [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/), [Journal of Nanoscience and Nanotechnology, 2010](https://pubmed.ncbi.nlm.nih.gov/21137794/)

### Where does this cleanser go in a skincare routine for mature skin?

This enzyme powder cleanser fits into a weekly routine for mature skin, used once a week to gently renew the skin while keeping it soft and smooth. Those who tolerate it well and see good results can carefully use it more often. It is safe for normal skin and is unlikely to cause irritation.

### Can I use it with retinol, and in what order?

You can use this enzyme wash with retinol by using them on different days or times, since combining active exfoliants directly with retinol may increase the likelihood of skin irritation.
Sources: [Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/)

### How often should I use this cleanser?

Start by using this enzyme powder cleanser once a week as part of your routine. If your skin tolerates it well and you see good results, you can carefully use it more often.

### Can it clog pores, cause breakouts or purging for mature skin?

IOPE Pro Peeling Enzyme Wash is unlikely to clog pores or cause breakouts for mature skin, as it contains gentle cleansing and hydrating ingredients like betaine and squalane. It helps renew the skin without harsh ingredients that typically trigger irritation.
Sources: [Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/), [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/)

### Is it fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (ethanol).

## Alternatives for mature skin

- [VT Cica Mild Powder Wash](https://lovi.care/skincare/ie/p/vt/cica-mild-powder-wash/for/mature-skin) — Superior fit — €8.99 at Amazon
- [By Wishtrend Green Tea & Enzyme Powder Wash](https://lovi.care/skincare/ie/p/by-wishtrend/green-tea-and-enzyme-powder-wash/for/mature-skin) — High fit — €15.91 at Amazon
- [Dr. Barbara Sturm Enzyme Cleanser](https://lovi.care/skincare/ie/p/dr-barbara-sturm/enzyme-cleanser/for/mature-skin) — High fit — €66.90 at Notino

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ie/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €56.86 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ie/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.28 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/ie/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €50.82 at Amazon

## Where to buy

No store in Ireland has a checked price for this product, so the page shows none.

## Ingredients

Microcrystalline Cellulose, Sodium Cocoyl Glycinate, Sodium Lauroyl Glutamate, Silica, Papain, Protease, Lipase, Lemon Fruit Extract, Saccharum Officinarum Extract, Sugar Maple Extract, Vaccinium Myrtillus Fruit Extract, Citrus Aurantium Dulcis Fruit Extract, Betaine, Squalane, Acetyl Glucosamine, Allantoin, Chitosan, Alpha-Glucan Oligosaccharide, Ethyl Cellulose, Ethanol, Xanthan Gum, Water, Butylene Glycol, Polycaprolactone, Peg-75, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/iope/pro-peeling-enzyme-wash/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/mature-skin (this page)
- Germany: https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/mature-skin
- France: https://lovi.care/skincare/fr/p/iope/pro-peeling-enzyme-wash/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/iope/pro-peeling-enzyme-wash/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/iope/pro-peeling-enzyme-wash/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/iope/pro-peeling-enzyme-wash/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/iope/pro-peeling-enzyme-wash/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/iope/pro-peeling-enzyme-wash/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/iope/pro-peeling-enzyme-wash/for/mature-skin