# HydroPeptide Power Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ie/p/hydropeptide/power-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Brand: [HydroPeptide](https://lovi.care/skincare/ie/brands/hydropeptide)
Category: [Serums and treatments](https://lovi.care/skincare/ie/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Excellent for your combination skin, this serum utilizes Hexapeptide-11 and Tetrahexyldecyl Ascorbate to effectively smooth texture and brighten your skin tone, addressing your concerns with acne and blemishes.
- The inclusion of Glycerin and Sodium Hyaluronate provides essential hydration, supporting your skin's repair processes and reducing inflammation without causing irritation.
- This formulation is safe for your acne-prone skin, containing soothing ingredients like Tocopherol and avoiding harsh components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ie/p/hydropeptide/power-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ie/p/hydropeptide/power-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ie/p/hydropeptide/power-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ie/p/hydropeptide/power-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ie/p/hydropeptide/power-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/ie/p/hydropeptide/power-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ie/p/hydropeptide/power-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ie/p/hydropeptide/power-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ie/p/hydropeptide/power-serum/for/oily-acne-prone-skin): High

## Key ingredients

Palmitoyl Tripeptide-5, Hexapeptide-11, Acetyl Hexapeptide-30, Sodium Hyaluronate, Lemon Peel Extract

## What the research says

- Hexapeptide-11 activated proteasome, autophagy, chaperones, and antioxidant response genes, protected fibroblasts against oxidative-stress-mediated premature cellular senescence, and improved skin elasticity in human subjects. ([Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Hexapeptide-11 reversibly downregulated ATM and p53 protein expression in intrinsically aged fibroblasts, extrinsically aged fibroblasts, and extrinsically aged dermal papillae cells at concentrations between 0.1% and 1.0% in vitro, thereby influencing the onset of cellular senescence. ([Journal of Cosmetic Science, 2013](https://pubmed.ncbi.nlm.nih.gov/23578831/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Users consistently praise this serum as a lightweight, non-greasy anti-aging powerhouse that visibly plumps and smooths the skin. While it is highly effective for hydrating dry skin and softening fine lines without irritating sensitive complexions, the high price point and distinct scent are occasional points of contention.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Visible anti-aging (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Gentle on skin (sometimes noted)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Packaging size (rarely noted)
- Disliked: Scent dislike (rarely noted)
- Disliked: Slow results (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes HydroPeptide Power Serum a great fit for acne-prone skin?

HydroPeptide Power Serum is a great fit for acne-prone skin because it uses gentle peptides and vitamin C to smooth texture and brighten tone while addressing blemishes. Ingredients like glycerin and sodium hyaluronate provide essential hydration to support skin repair and reduce inflammation without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum is a great fit for your acne-prone skin because it uses Hexapeptide-11 and Tetrahexyldecyl Ascorbate to smooth texture and brighten your tone, while Glycerin and Sodium Hyaluronate provide essential hydration to reduce inflammation without causing irritation. It also contains soothing ingredients like Tocopherol and avoids harsh components, making it safe and gentle for blemish-prone skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Palmitoyl Tripeptide-5 do for acne-prone skin?

Palmitoyl Tripeptide-5 helps improve skin texture and firmness, making it a supportive addition for acne-prone skin that needs smoothing without heavy oils.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/)

### What does Hexapeptide-11 do for acne-prone skin?

Hexapeptide-11 is a peptide that may help improve skin elasticity and support overall skin health. For acne-prone skin, a product of this type needs soothing ingredients and lightweight hydrators that help calm redness and keep the skin barrier strong.
Sources: [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in the evening routine after cleansing and before moisturizing, following Lovi's routine for acne-prone skin.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the treatment after your retinol to help calm the skin and provide hydration without causing irritation. Using soothing ingredients alongside active treatments is unlikely to cause issues and may reduce potential skin discomfort.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

This serum is a great fit for your acne-prone skin and is best used in your evening routine for simplicity and extra safety around sun exposure. It helps smooth texture and brighten skin tone while providing essential hydration and reducing inflammation without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is a great fit for acne-prone skin because it relies on soothing ingredients and avoids harsh components that typically cause breakouts. It helps hydrate your skin and calm inflammation safely without clogging pores.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Redox Biology, 2015](https://pubmed.ncbi.nlm.nih.gov/25974626/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/ie/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — €14.94 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/ie/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — €52.57 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ie/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — €185.00 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/ie/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.40 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/ie/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €19.99 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/ie/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €18.99 at Amazon

## Where to buy

No store in Ireland has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Lactococcus Lysate Ferment, Butylene Glycol, Propanediol, Diethylhexyl Carbonate, Isopentyldiol, Pentylene Glycol, Diheptyl Succinate, Caprylyl Glycol, Hydroxyacetophenone, Olea Europaea Fruit Olive Fruit, Sodium Stearoyl Glutamate, Cetearyl Alcohol, Glyceryl Stearate, Potassium Olivoyl Hydrolyzed Oat Protein, Lysolecithin, Sclerotium Gum, Hexapeptide-11, Tetrahexyldecyl Ascorbate, 1,2-Hexanediol, Capryloyl Glycerin Sebacic Acid Copolymer, Phenylpropanol, Sorbitan Laurate, Pullulan, Xanthan Gum, Caprylic Capric Triglyceride, Glyceryl Oleate, Glycine Soja Seed Extract Soybean Seed Extract, Anogeissus Leiocarpus Bark Extract, Lemon Peel Extract, Palmitoyl Hexapeptide-19, Sodium Phytate, Hydroxyethylcellulose, Sodium Hyaluronate, Acetyl Dipeptide-1 Cetyl Ester, Citrus Aurantium Dulcis Peel Extract, Grapefruit Fruit Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Bergamot Fruit Extract, Citrus Aurantifolia Peel Extract, Citrus Nobilis Fruit Extract Mandarin Orange Fruit Extract, Tangerine Peel Extract, Acetyl Hexapeptide-30, Barosma Betulina Leaf Extract, Vanilla Planifolia Fruit Extract, Vitis Vinifera Fruit Extract Grape Fruit Extract, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Tripeptide-5, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/hydropeptide/power-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/hydropeptide/power-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/hydropeptide/power-serum/for/acne-prone-skin (this page)
- Germany: https://lovi.care/skincare/de/p/hydropeptide/power-serum/for/acne-prone-skin
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