Eighth Day Regenerative Serum for oily acne-prone skin
Peptide-Rich Plasma
Sodium Hyaluronate
Niacinamide
Acetyl Glutamine
Manuka Honey
Average
- HighOily Skin Fit
- AverageEffectiveness
- Low RiskSafety
Works for oily acne-prone skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate exfoliation and oil control for your oily skin due to niacinamide and glycolic acid, which help to regulate sebum and shed dead skin cells. The peptides and hyaluronic acid provide excellent hydration and support for minimizing fine lines and wrinkles, though they do not specifically target acne, blemishes, and breakouts.
- The serum offers general skincare benefits like hydration and soothing, which are supportive but not the primary focus for your main concerns.
- The product is generally safe for your oily skin, with a low risk of irritation from glycolic acid.
How to apply
- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
People Say
★4.5Overall rating based on 300+ reviewsThis serum is highly praised for its "Peptide-Rich Plasma" technology, which users credit for rapidly improving skin texture, firmness, and radiance. While many describe it as a "holy grail" for anti-aging and hydration, a subset of users feel the high price tag is not justified by the results, which can be subtle for some.
Highlights
High price Mostly Mentioned
- “hefty price tag”
- “hard to justify”
- “investment skincare”
- “wallet-draining”
Fast absorption Often Mentioned
- “Lightweight, non-sticky, sinks in immediately, satin finish, layers well”
Visible anti-aging Often Mentioned
- “Smoother fine lines, plumper skin, increased firmness, brighter complexion, "instant glow."”
High-tech ingredients Sometimes Noted
- “Peptide-Rich Plasma, bio-identical actives, stem cell technology, clean formula, fragrance-free”
Hydration Sometimes Noted
- “Deeply hydrating, restores moisture barrier, skin feels bouncy, eliminates dryness”
Lack of results Sometimes Noted
- “No visible difference”
- “didn't work for me”
- “overhyped”
- “saw no change”
- “cheaper alternatives work better”
Packaging Rarely Noted
- “Sleek black bottle, airless pump, luxurious design, dispenses perfect amount”
Availability issues Rarely Noted
- “Frequently sold out”
- “hard to find”
- “waitlists”
- “stock issues”
No acne benefit Rarely Noted
- “Did not help breakouts”
- “didn't reduce acne”
- “neutral on blemishes”
Texture complaints Rarely Noted
- “Slightly tacky for some”
- “hard to spread (rare)”
- “leaves a film”
- “requires quick application”
Sources: lovi.care, nordstrom.com, violetgrey.com, editorialist.com, whowhatwear.com, reddit.com, and more
Questions and answers
How well does Eighth Day Regenerative Serum work for oily acne-prone skin?
Eighth Day Eighth Day Regenerative Serum is an average fit for oily acne-prone skin because it offers moderate oil control and hydration, though it does not specifically target breakouts. A product of this type needs ingredients like niacinamide, propolis, or Vitamin C that provide excellent benefits for acne without heavy or pore-clogging components, along with soothing extracts and antioxidants to maintain balanced skin health.
Scientific Reports, 2024Clinical, Cosmetic and Investigational Dermatology, 2019
Which ingredients make this serum a good fit for oily acne-prone skin?
Niacinamide and glycolic acid make this serum a fit by offering moderate oil control and shedding dead skin cells. Oily acne-prone skin needs products with effective ingredients like niacinamide and propolis or vitamin C that target acne, control excess oil, and soothe without irritation.
What does Peptide-Rich Plasma do for oily acne-prone skin?
Platelet-rich plasma helps improve inflammatory and non-inflammatory acne lesions and acne scars when used in professional treatments. This type of skin needs soothing ingredients and professional care to calm breakouts and smooth texture.
Lasers in Medical Science, 2022Aesthetic Plastic Surgery, 2026
What does Hyaluronic Acid do for oily acne-prone skin?
Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.
The Journal of Investigative Dermatology, 2017Journal of Cosmetic Dermatology, 2022
Where does it go in a skincare routine for oily acne-prone skin?
This serum goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. Because this is an average fit for your skin, an ideal product of this type for oily acne-prone skin needs ingredients that directly target breakouts and blemishes alongside oil control and gentle exfoliation.
Can I use this serum with retinol, and in what order?
You can use this treatment alongside retinol by applying the retinol first and following with this serum, or by using them on alternating nights to keep your skin calm and comfortable. This approach helps you gain the hydrating and oil-regulating benefits of both products while lowering the likelihood of dryness or irritation.
How often should I use it?
Apply this treatment in the evening as part of your nighttime routine, starting once a week to see how your skin tolerates it. Oily acne-prone skin needs a product of this type to include targeted blemish-fighting ingredients and oil-control agents like salicylic acid or retinoids to properly address breakouts.
Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?
This serum is unlikely to clog pores or cause breakouts on oily skin, and the low amount of glycolic acid may cause very mild shedding without true purging. It offers moderate oil control and hydration, but an oily acne-prone skin needs products with ingredients specifically targeting blemishes and breakouts.
Is it fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.
Scientific Reports, 2024Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG.
Drug Delivery, 2017Glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene showed no hindrance compared to adapalene monotherapy and provided benefits in reducing complications in 25 subjects with mild-to-moderate acne vulgaris.
Clinical, Cosmetic and Investigational Dermatology, 2019Topical insulin combined with fractional CO2 laser showed no significant difference in efficacy compared to topical PRP combined with fractional CO2 laser for atrophic acne scars in 30 patients.
Archives of Dermatological Research, 2025Subcision and microneedling combined with topical platelet-rich plasma resulted in significantly greater improvement in scar grading compared to subcision and microneedling alone in patients with atrophic scars.
Journal of Cutaneous and Aesthetic Surgery, 2024Platelets remain viable for up to 90 days in a refrigerated cosmetic vehicle with demonstrated topical clinical PRP facial benefits, and 20ml and 60ml PRP volumes are equally efficacious.
Journal of Drugs in Dermatology, 2020Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical overnight application of MGO Manuka Honey microemulsion eye cream significantly reduced symptomology, improved tear film stability and lipid layer thickness, and decreased lid margin staining, ocular Demodex, and bacterial load in patients with blepharitis compared to control eyes.
The Ocular Surface, 2020Optimel 16% manuka honey eye-drops significantly improved symptoms and objective signs in patients with meibomian gland dysfunction compared to baseline after 3 weeks.
The British Journal of Ophthalmology, 2022The application of Manuka honey and the GENADYNE A4 negative pressure wound therapy system in a 55-year-old woman with extensive phlegmonous and necrotic lesions following traumatic colonic rupture successfully enabled skin autografting and complete wound healing.
Medical Science Monitor, 2010
Why other serums fit oily acne-prone skin better
A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.
Clinical Pharmacology, 2018Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.
BioMed Research International, 2022
Ingredients
Water, Pentylene Glycol, Peptide-Rich Plasma, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Acetyl Hexapeptide-8, Sh-Oligopeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Acetyl Glutamine, Sodium Hyaluronate, Lysine Hcl, Alanine, Histidine Hcl, Arginine, Serine, Proline, Glutamic Acid, Threonine, Valine, Leucine, Glycine, Isoleucine, Phenylalanine, Taurine, Glycerin, Hedychium Coronarium Root Extract, Tripeptide-1, Polygonum Aviculare Extract, Honey, Nonapeptide-1, Acetyl Heptapeptide-4, Phytosphingosine, Sea Whip Extract, Niacinamide, Hydrolyzed Hyaluronic Acid, Aminobutyric Acid, Adenosine, Thioctic Acid, Glycolic Acid, Bacillus Soybean Folic Acid Extract Ferment, Polysorbate 20, Allantoin, Caprylyl Glycol, Lecithin, Butylene Glycol, 1,2-Hexanediol, Dextran, Phenoxyethanol, Ethylhexylglycerin, Xanthan Gum
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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