Dermalogica Circular Hydration Serum for acne-prone skin

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Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

  American Journal of Clinical Dermatology, 2002

• A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

  The Journal of Dermatological Treatment, 2017

• A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.

  Journal of Cosmetic Dermatology, 2025

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• A repair cream containing Rhealba oat plantlets extract, l-ALA-l-GLU dipeptide, and hyaluronic acid provided immediate relief and was judged by doctors as good or very good in 96.8% of cases for wound healing in 2,363 patients following dermatological acts.

  Clinical, Cosmetic and Investigational Dermatology, 2018

• Topically applied Avena sativa and Avena Rhealba oatmeal extracts significantly reduced skin irritation parameters including a* parameter increase and blood flow increase compared to vehicle in 12 healthy individuals subjected to the sodium lauryl sulfate irritation model.

  Skin Pharmacology and Applied Skin Physiology, 2002

• Colloidal oat extracts diminished pro-inflammatory cytokines in vitro and colloidal oat lotion improved skin dryness, scaling, roughness, and itch intensity in healthy female subjects compared to baseline.

  Journal of Drugs in Dermatology, 2015

• A Dunaliella salina extract significantly reduced skin glycation scores, histamine sensitivity, wrinkle counts, and spots compared to placebo under intense solar exposure.

  Marine Drugs, 2022

• Phytoene- and phytofluene-rich tomato and Dunaliella salina extracts show no significant cytotoxic, genotoxic, irritant, or sensitizing potential, supporting their safe human topical use.

  Journal of Toxicology, 2018

• Curcumin-loaded polyglutamic acid and gum arabic electrospun nanofibers accelerated wound healing, increased TGF-beta1 and VEGF expression, reduced inflammatory factors, and enhanced re-epithelialization and tissue regeneration in a mouse model with acute full-thickness skin defects.

  International Journal of Biological Macromolecules, 2024

• Polyglutamic acid and polylysine composite hydrogels promote wound repair and hemostasis through high water absorption, bioadhesion, calcium ion-mediated coagulation factor activation, and inherent antibacterial properties in a deep skin defect model.

  Macromolecular Bioscience, 2021

Ingredients

Water, Peg-8, Glycerin, Methylpropanediol, Propanediol, Ppg-24-Glycereth-24, 1,2-Hexanediol, Xylitylglucoside, Butylene Glycol, Hydroxyethyl Urea, Panthenol, Hydroxyacetophenone, Lactic Acid, Sodium Hyaluronate, Dunaliella Salina Extract, Avena Sativa Kernel Extract Oat Kernel Extract, Bergamot Oil Fruit, Grapefruit Peel Oil, Lemon Peel Oil, Sandalwood Oil, Laminaria Digitata Extract, Jasminum Sambac Flower Extract Jasmine Flower Extract, Chondrus Crispus Extract, Gigartina Stellata Extract, Macrocystis Pyrifera Extract Kelp Extract, Prunus Amygdalus Dulcis Oil, Lithothamnion Calcareum Extract, Citrus Aurantium Dulcis Oil, Cupressus Sempervirens Oil, Cistus Ladaniferus Stem Extract Leaf, Juniperus Virginiana Oil, Rosamarinus Officinalis Stem Extract Flower Leaf Rosemary Stem Extract Flower Leaf, Tagetes Minuta Oil Flower, Rosa Damascena Flower, Hydrolyzed Rice Protein, Pentylene Glycol, Sodium Pca, Anhydroxylitol, Xylitol, Polyglutamic Acid, Lactobacillus Ferment, Lysine Hcl, Betaine, Sclerotium Gum, Sodium Lactate, Pca, Glucose, Serine, Alanine, Glycine, Silanetriol, Pantolactone, Glutamic Acid, Threonine, Arginine, Proline, Xanthan Gum, Tetrasodium Glutamate Diacetate, Polysorbate 20, Sorbitan Isostearate, Citric Acid, Sodium Hydroxide, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Amylopectin, Hydroxyethylcellulose, Sodium Benzoate, Potassium Sorbate, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.