# Dear, Klairs Midnight Blue Youth Activating Drop for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ie/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Brand: [Dear, Klairs](https://lovi.care/skincare/ie/brands/dear-klairs)
Category: [Serums and treatments](https://lovi.care/skincare/ie/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- This product offers excellent skin rejuvenation for your combination skin, as Sh-Oligopeptide-1 and Sh-Polypeptide-1 promote collagen stimulation and boost extracellular matrix synthesis to minimize fine lines and wrinkles.
- Blueberry fruit extract and adenosine further enhance skin regeneration and improve texture, addressing your concerns with oily shine.
- The formula is safe for your skin, with Guaiazulene providing soothing benefits and no harsh ingredients present.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ie/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ie/p/dear-klairs/midnight-blue-youth-activating-drop/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ie/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/ie/p/dear-klairs/midnight-blue-youth-activating-drop/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ie/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ie/p/dear-klairs/midnight-blue-youth-activating-drop/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ie/p/dear-klairs/midnight-blue-youth-activating-drop/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ie/p/dear-klairs/midnight-blue-youth-activating-drop/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ie/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin): High

## Key ingredients

Rh-Oligopeptide-1, Sh-Oligopeptide-1, Sh-Polypeptide-1, Blueberry Fruit Extract, Guaiazulene

## What the research says

- Bovine basic fibroblast growth factor combined with ultrapulsed fractional CO2 laser increased the overall response rate, reduced ECCA scores, scar base depth, skin pore value, texture value, transepidermal water loss, redness duration, scabbing duration, erythema duration, and adverse reactions, while increasing skin water and epidermal oil content in patients with acne scars compared to ultrapulsed fractional CO2 laser therapy alone. ([Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37841061/))
- Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone. ([The New England Journal of Medicine, 1989](https://pubmed.ncbi.nlm.nih.gov/2659995/))
- Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba. ([Lasers in Surgery and Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/30614013/))
- Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars. ([The Journal of Clinical and Aesthetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35942017/))
- Topical application of PTD-EGF and FGF1 increased cell proliferation and collagen accumulation while protecting against UV-induced damage and improving wrinkle parameters in human skin. ([Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/24305427/))
- Basic fibroblast growth factor-loaded human serum albumin nanoparticles enhanced the proliferation and migration of human dermal fibroblasts, down-regulated myofibroblast-related genes, and accelerated wound healing with enhanced angiogenesis in vivo compared to unstable native forms. ([Journal of Nanobiotechnology, 2023](https://pubmed.ncbi.nlm.nih.gov/37658367/))
- Topical application of basic fibroblast growth factor decreases elevated transepidermal water loss and increases Ki67 expression in keratinocytes following mechanical scratching in a mouse model. ([Skin Pharmacology and Physiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23108135/))
- Applying a topical product containing blueberry extract and Pro-xylane following micro-focused ultrasound significantly improved global aesthetic improvement, skin elasticity, and fine lines compared to standard moisturizer in 50 patients. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40635529/))
- Topical usage of blueberries may prevent skin damage from environmental stressors by inducing an active skin response against noxious effects. ([Antioxidants, 2023](https://pubmed.ncbi.nlm.nih.gov/37371992/))
- Pretreatment with blueberry extracts prevented ozone-induced ROS production, NLRP1-ASC scaffold formation, and CASP1 and IL-18 transcripts across 2D, 3D, and human skin explant models. ([Oxidative Medicine and Cellular Longevity, 2020](https://pubmed.ncbi.nlm.nih.gov/32855770/))

## What reviewers say

Based on a very large amount of data, this product is widely praised as a lightweight, watery anti-aging serum that absorbs instantly and is exceptionally gentle, making it a favorite for oily and sensitive skin types. Many users report smoother skin texture, reduced redness, and a plump feel. Some find the 20ml bottle too small for the price and note that its preventative anti-aging effects take time to become visible.

- Liked: Rapid absorption (mostly mentioned)
- Disliked: Small volume/price (mostly mentioned)
- Liked: Gentle formula (often mentioned)
- Liked: Soothing & calming (often mentioned)
- Liked: Improves texture (sometimes noted)
- Disliked: Slow visible results (sometimes noted)
- Disliked: Watery consistency (sometimes noted)
- Disliked: Not moisturizing (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Dear, Klairs Midnight Blue Youth Activating Drop a great fit for combination skin?

This treatment is a great fit for your combination skin because peptides help boost collagen to smooth fine lines, while blueberry extract and adenosine improve your texture and help manage oily shine. It also features soothing ingredients like Guaiazulene to help keep your skin calm and safe from irritation.

### Which ingredients make this serum a good fit for combination skin?

Sh-Oligopeptide-1, Sh-Polypeptide-1, and blueberry fruit extract make this serum a great fit by smoothing fine lines and managing oily shine on combination skin. Guaiazulene also helps keep your skin calm and is very safe to use.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37841061/)

### What does EGF do for combination skin?

EGF helps support cell turnover and collagen production, which may improve firmness and keep combination skin looking smooth and even. For the best results on combination skin, this ingredient works well alongside hydrating ingredients like hyaluronic acid to balance oilier and dry areas.
Sources: [Journal of Drugs in Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30909351/), [Cell Proliferation, 2022](https://pubmed.ncbi.nlm.nih.gov/35274780/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in your evening routine after your cleansing toner and before your moisturizer. Putting it in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to let it absorb, followed by your retinol. This approach helps keep your combination skin smooth and calm while minimizing fine lines.

### How often should I use this serum?

This treatment is meant for your evening routine, where it helps smooth fine lines and improve texture on combination skin. It is safe for regular use as part of your nightly routine, while providing soothing benefits through ingredients like Guaiazulene.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts on combination skin. Its lightweight formula is safe and contains soothing ingredients that help calm the skin without heavy, pore-blocking oils.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/ie/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — €14.94 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/ie/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €52.57 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/ie/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €385.99 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ie/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — €56.86 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/ie/p/la-mer/the-tonic/for/combination-skin) — Superior fit — €115.30 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ie/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — €16.50 at Amazon

## Where to buy

- Notino: €25.50 (https://www.notino.ie/klairs/midnight-blue-activating-serum-for-skin-rejuvenation/p-11635961/)
Prices checked 10 Oct 2026.

## Ingredients

Water, Butylene Glycol, Sh-Oligopeptide-1, Sh-Polypeptide-1, Blueberry Fruit Extract, Lecithin, Sorbitan Sesquioleate, 1,2-Hexanediol, Caprylyl Glycol, Peg-60 Hydrogenated Castor Oil, Glycerin, Chlorphenesin, Guaiazulene, Ethylhexylglycerin, Adenosine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin (this page)
- Germany: https://lovi.care/skincare/de/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin
- France: https://lovi.care/skincare/fr/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin