# Anua NANO RETINOL™ 0.3% + NIACIN RENEWING SERUM for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ie/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Brand: [Anua](https://lovi.care/skincare/ie/brands/anua)
Category: [Serums and treatments](https://lovi.care/skincare/ie/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers high suitability for your oily skin as niacinamide and retinol work synergistically to regulate sebum production and promote skin renewal, addressing your concerns with acne, blemishes, and breakouts. Glycerin and panthenol further support hydration and soothe the skin, enhancing the overall efficacy for your skin type.
- The formulation is well-balanced with humectants like hyaluronic acid and betaine to maintain skin hydration without exacerbating oiliness.
- The safety profile is excellent, with no harsh ingredients and a good balance of soothing agents, making it suitable for your non-sensitive oily skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ie/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ie/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ie/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ie/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ie/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ie/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ie/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ie/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ie/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Retinol, Niacinamide, Hyaluronic Acid, Panthenol, Allantoin

## What the research says

- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/))
- Soaps containing betaine caused the least skin irritation compared to other tested soaps in twenty-eight healthy subjects, though irritation did not decrease with increasing concentrations of betaine. ([Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))

## What reviewers say

Users find this serum to be an excellent gentle introduction to retinol, effectively smoothing skin texture and refining pores with minimal irritation. While improvements to fine lines and blackheads require consistent use, the formula hydrates and plumps the skin, leaving it glowing and moisturized.

- Liked: Gentle & non-irritating (often mentioned)
- Liked: Improves texture & pores (often mentioned)
- Liked: Brightening effect (sometimes noted)
- Liked: Elegant texture (sometimes noted)
- Liked: Hydrating & plumping (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Initial sensitivity (rarely noted)
- Disliked: Scent preferences (rarely noted)
- Disliked: Small quantity (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Anua Nano Retinol 0.3% + Niacin Renewing Serum a great fit for oily acne-prone skin?

This serum is a great fit for your oily acne-prone skin because niacinamide and retinol help regulate oil and encourage skin renewal to tackle breakouts. Hyaluronic acid and glycerin keep your skin hydrated without feeling greasy, while panthenol and allantoin soothe the skin.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Retinol and niacinamide make this serum a great fit because they work together to regulate oil production and help clear up breakouts. Glycerin, panthenol, and hyaluronic acid keep your skin hydrated without feeling greasy, while soothing agents keep the formula gentle.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Retinol do for oily acne-prone skin?

Retinol helps oily acne-prone skin by clearing up breakouts and smoothing the skin, though it may occasionally cause some mild scaling or stinging. This ingredient works by addressing the root causes of acne, making it a reliable choice for keeping pores clear and skin smooth.
Sources: [American Journal of Clinical Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30674002/), [Journal of Drugs in Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/30586483/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment serum goes in the evening routine after cleansing and toning, and before moisturizing. Putting treatments in the evening helps with simplicity and extra safety around sun exposure.

### Can I use this serum with vitamin C, and in what order?

You can use this serum with vitamin C by applying vitamin C in your morning routine and this treatment at night, as using both at the same time may cause too much irritation. This serum pairs well with your routine because soothing ingredients like panthenol and allantoin help keep your skin calm while active ingredients work.

### How often should I use this serum?

You can use this treatment in your evening routine, starting just once a week and gradually using it more often if your skin tolerates it well. Retinol and niacinamide help regulate oil and renew your skin, while soothing ingredients keep your oily acne-prone skin comfortable.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is a great fit for your oily acne-prone skin because retinol and niacinamide help regulate oil and encourage skin renewal to tackle breakouts. It also includes soothing and hydrating ingredients like panthenol and glycerin to keep your skin calm and balanced without feeling heavy.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/ie/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — €14.94 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/ie/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — €29.07 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/ie/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — €31.40 at Amazon

## Pairs well with

- Cleanser: [IS Clinical Cleansing Complex](https://lovi.care/skincare/ie/p/is-clinical/cleansing-complex/for/oily-acne-prone-skin) — Superior fit — €95.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ie/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ie/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — €16.50 at Amazon

## Where to buy

- Amazon.ie: €32.00 (https://www.amazon.ie/dp/B0CRSZDX59?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
Prices checked 4 Nov 2026.

## Ingredients

Water, Niacinamide, Glycerin, Butylene Glycol, 1,2-Hexanediol, Panthenol, Hyaluronic Acid, Allantoin, Betaine, Tocopherol, Ethylhexylglycerin, Adenosine, Caprylyl Glycol, Xanthan Gum, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin (this page)
- Germany: https://lovi.care/skincare/de/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/anua/nano-retinoltm-0-3-niacin-renewing-serum/for/oily-acne-prone-skin