Alastin Skincare HA Immerse Serum for mature skin
Sodium Hyaluronate
Tremella Fuciformis Sporocarp Extract Silver Ear Mushroom Extract
Hexapeptide-11
Lactoferrin
Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate
High
- HighNormal Skin Fit
- HighEffectiveness
- ExcellentSafety
One of the best moisturizers for mature skin.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent for your normal skin, this serum effectively targets wrinkles and fine lines with specialized peptides like Octapeptide-45 and Hexapeptide-11 to promote collagen synthesis and elasticity.
- Its highly moisturizing formula, featuring Sodium Hyaluronate and Glycerin, provides excellent hydration and plumping effects, further enhancing skin texture and smoothness.
- The product is safe for your skin, containing soothing ingredients like Tocopherol and Tremella Fuciformis Sporocarp Extract, with no risk of irritation.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
People Say
★4.7Overall rating based on 400+ reviewsThis serum is widely celebrated for its transformative hydrating properties, with users reporting significant improvements in skin suppleness, radiance, and the reduction of fine lines. It is particularly favored by those with dry or mature skin for its ability to provide a "plumped" and youthful appearance without causing irritation or leaving a heavy, sticky residue.
Highlights
Instant hydration Mostly Mentioned
- “Hydrates and plumps instantly”
- “Sweet, sweet relief”
- “Quenches all the dryness”
Layers well Often Mentioned
- “Doesn't pill under makeup”
- “Layers well with other products”
- “No mask-like feeling”
Non-greasy texture Often Mentioned
- “No greasy residue”
- “Lightweight, absorbs completely”
- “Smooth and silky”
High price Often Mentioned
- “A little pricey”
- “Triple dollar sign territory”
- “Worth the investment but pricey”
Smooths fine lines Sometimes Noted
- “Less creases”
- “Lines look smoother”
- “Don't see them when I use this”
Packaging issues Rarely Noted
- “Pop-up part stops working”
- “Inner chamber came loose”
- “Rendered the spout useless”
Product longevity Rarely Noted
- “Wish it lasted longer”
- “Need to reapply during the day”
Sources: lovi.care, alastin.com, ellemesmedspa.com, lovelyskin.com, newbeauty.com, nicolesimonek.com, and more
Questions and answers
What makes Alastin HA Immerse Serum a great fit for mature skin?
Alastin Skincare HA Immerse Serum is a great fit for mature skin because it targets wrinkles and fine lines using specialized peptides like Octapeptide-45 and Hexapeptide-11 to boost collagen and elasticity. Its moisturizing formula with sodium hyaluronate and glycerin provides deep hydration and plumping effects, while soothing ingredients like tocopherol and silver ear mushroom extract keep your skin calm and smooth with a very low risk of irritation.
Redox Biology, 2015Clinical, Cosmetic and Investigational Dermatology, 2017
Which ingredients make this serum a good fit for mature skin?
This serum is a great fit for mature skin because it contains specialized peptides like Hexapeptide-11 and Octapeptide-45 that help smooth out fine lines and wrinkles. It also includes sodium hyaluronate and glycerin to provide deep hydration and leave your skin feeling plump and soft.
Redox Biology, 2015Clinical, Cosmetic and Investigational Dermatology, 2017
What does Hyaluronic Acid do for mature skin?
Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Journal of Drugs in Dermatology, 2011Skin Research and Technology, 2024
What does Tremella Fuciformis Sporocarp Extract do for mature skin?
Tremella Fuciformis Sporocarp Extract helps mature skin stay soft and smooth by holding onto moisture while also protecting against everyday damage that can make skin look tired. It supports the skin barrier and may help calm irritation, keeping your complexion looking fresh and healthy. Products for mature skin benefit most when they pair this ingredient with deep hydrators and antioxidants.
Molecular Medicine Reports, 2017Photochemical & Photobiological Sciences, 2023
Where does this serum go in a skincare routine for mature skin?
This serum goes in the evening routine after cleansing and before moisturizing, which keeps the routine simple and safe around sun exposure. Using targeted treatments at night helps support collagen synthesis and elasticity for mature skin.
Can I use this serum with retinol, and in what order?
You can use this serum alongside retinol, applying the serum first to hydrate and smooth your skin before your retinol product. This helps keep mature skin comfortable and is unlikely to cause irritation.
Cutis, 2006Clinical, Cosmetic and Investigational Dermatology, 2017
How often should I use this serum?
This serum fits well into your evening routine as a treatment step, used once a day for simplicity and extra safety around sun exposure. Applying it consistently helps improve hydration, firmness, and fine lines over time.
Journal of Cosmetic Dermatology, 2020Journal of Drugs in Dermatology, 2015
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is a great fit for mature skin and is unlikely to clog pores, cause breakouts, or lead to purging. Its soothing ingredients and gentle moisturizing formula make it well-suited for regular use without causing irritation.
Can I use this serum around the eyes or on my body?
You can use this moisturizing treatment around the eyes or on the body, though the skin around the eyes and on certain body areas is very thin and may react differently than facial skin. Its hydrating formula helps keep thin areas smooth and plump, while peptides like Hexapeptide-11 improve elasticity with a very low risk of irritation.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Hexapeptide-11 activated proteasome, autophagy, chaperones, and antioxidant response genes, protected fibroblasts against oxidative-stress-mediated premature cellular senescence, and improved skin elasticity in human subjects.
Redox Biology, 2015The addition of Octapeptide-45 to TriHex technology (TriHex 2.0) significantly increased hyaluronic acid levels and tropoelastin intensity compared to untreated tissue, while also upregulating genes affecting the extracellular matrix and basement membrane.
Journal of Cosmetic Dermatology, 2025A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022Pre-treatment with Tremella fuciformis polysaccharide reduced oxidative stress and cell apoptosis in hydrogen peroxide-treated human skin fibroblasts via the upregulation of SIRT1 expression.
Molecular Medicine Reports, 2017Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Snow mushroom alcohol-based hand rub gel significantly improved skin moisture better than the placebo through 180 minutes while maintaining comparable antiseptic efficacy in 20 human volunteers.
Journal of Cosmetic Dermatology, 2021Tremella fuciformis extract demonstrates potential cutaneous benefits including skin antiaging, photoprotection, wound healing, and barrier protection based on in vitro and animal models.
Archives of Dermatological Research, 2023Tremella fuciformis inhibits melanogenesis by decreasing melanin content and tyrosinase expression in B16F10 cells while promoting wound healing in human HaCaT keratinocytes and Detroit 551 fibroblasts.
In Vivo, 2022Hexapeptide-11 reversibly downregulated ATM and p53 protein expression in intrinsically aged fibroblasts, extrinsically aged fibroblasts, and extrinsically aged dermal papillae cells at concentrations between 0.1% and 1.0% in vitro, thereby influencing the onset of cellular senescence.
Journal of Cosmetic Science, 2013The combination of sodium ascorbate and lactoferrin demonstrated a significant synergistic effect on tropoelastin stimulation with intact and increased elastin fibers compared to single treatments in an ex vivo human skin model.
Journal of Cosmetic Dermatology, 2024Colostrum-derived exosome-encapsulated lactoferrin promoted cell viability and migration while reducing pro-inflammatory cytokines and phosphorylated JNK in mouse NIH/3T3 and human HS-68 fibroblasts treated with lipopolysaccharide.
Current Issues in Molecular Biology, 2025Lactoferrin treatment decreased lipid content and attenuated the mRNA expression of lipid metabolism and inflammatory genes in SZ95 human sebocytes, and reduced inflammation, lipid production, and sebaceous gland cell proliferation while increasing apoptosis in a mouse model of acne.
Journal of Cosmetic Dermatology, 2023
Ingredients
Water, Glycerin, Polyacrylate-13, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Octapeptide-45, Hexapeptide-11, Tremella Fuciformis Sporocarp Extract Silver Ear Mushroom Extract, Lactoferrin, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Xylitol, Propanediol, Anhydroxylitol, Xylitylglucoside, Phosphatidylserine, Glucose, Hydroxymethoxyphenyl Decanone, Tocopherol, Ascorbyl Palmitate, Dimethicone, Caprylyl Methicone, Caprylic Capric Triglyceride, Polyisobutene, Caprylyl Glycol, Disodium Edta, Betaine, Polysorbate 20, Ethylhexylglycerin, Caprylhydroxamic Acid, Sorbitan Isostearate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Lecithin, Pentylene Glycol, Magnesium Chloride, Phenoxyethanol, Potassium Sorbate, Sodium Hydroxide
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
-
Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
-
Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
-
Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
-
Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
-
Medical Board
Cosmetic chemist, SCS, IFSCC member
-
Medical Board, Medical Advisor
Dermatology MD
-
Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
-
Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.