# Vitamin A and palmitoyl pentapeptide-4

Page: https://lovi.care/skincare/ie/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Keep them apart

Use them at different times of day by applying [vitamin A](https://lovi.care/skincare/ie/ingredients/vitamin-a) at night and [palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/palmitoyl-pentapeptide-4) in the morning to avoid extra skin irritation. Using both strong ingredients at the same time can cause your skin to become red, sensitive, and irritated. You can solve this by switching to a gentler strength or waiting longer between applying the two products.

- [All about vitamin A](https://lovi.care/skincare/ie/ingredients/vitamin-a)
- [All about palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/palmitoyl-pentapeptide-4)

### [Vitamin A](https://lovi.care/skincare/ie/ingredients/vitamin-a) products

- [Bio-Oil Skincare Oil](https://lovi.care/skincare/ie/p/bio-oil/skincare-oil/for/dry-skin) — Average fit — [€25.49 at Amazon](https://www.amazon.ie/dp/B004AI97MA?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [ZO Skin Health Exfoliating Polish](https://lovi.care/skincare/ie/p/zo-skin-health/exfoliating-polish/for/mature-skin) — High fit
- [Peter Thomas Roth Instant FIRMx Eye Temporary Eye Tightener](https://lovi.care/skincare/ie/p/peter-thomas-roth/instant-firmx-eye-temporary-eye-tightener/for/mature-skin) — High fit — [€14.90 at Amazon](https://www.amazon.ie/dp/B0B8PXXPQN?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Peter Thomas Roth Instant FirmX Temporary Face Tightener](https://lovi.care/skincare/ie/p/peter-thomas-roth/instant-firmx-temporary-face-tightener/for/mature-skin) — Average fit
- [Augustinus Bader The Cream](https://lovi.care/skincare/ie/p/augustinus-bader/the-cream/for/mature-skin) — High fit — [€348.17 at Amazon](https://www.amazon.ie/dp/B08WH421M7?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [U Beauty Resurfacing Compound](https://lovi.care/skincare/ie/p/u-beauty/resurfacing-compound/for/dark-spots) — High fit
- [Philosophy Hope In A Jar](https://lovi.care/skincare/ie/p/philosophy/hope-in-a-jar/for/dark-spots) — Average fit
- [SkinMedica TNS Eye Repair](https://lovi.care/skincare/ie/p/skinmedica/tns-eye-repair/for/mature-skin) — Superior fit
- [Dermalogica Multivitamin Power Recovery Masque](https://lovi.care/skincare/ie/p/dermalogica/multivitamin-power-recovery-masque/for/mature-skin) — High fit — [€66.90 at Notino](https://www.notino.ie/dermalogica/age-smart-multivitamin-regenerating-mask/p-508929/)
- [BYOMA Sensitive Retinol Oil](https://lovi.care/skincare/ie/p/byoma/sensitive-retinol-oil/for/dry-skin) — Average fit
- [NatureWell Extra Virgin Coconut Oil Moisturizing Cream](https://lovi.care/skincare/ie/p/naturewell/extra-virgin-coconut-oil-moisturizing-cream/for/mature-skin) — Average fit
- [Murad Essential-C Cleanser](https://lovi.care/skincare/ie/p/murad/essential-c-cleanser/for/mature-skin) — High fit

### [Palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/palmitoyl-pentapeptide-4) products

- [Olay Eye Lifting Serum](https://lovi.care/skincare/ie/p/olay/eye-lifting-serum/for/dry-skin) — High fit

## Questions and answers

### Can you use vitamin A and palmitoyl pentapeptide-4 together?

Keep [vitamin A](https://lovi.care/skincare/ie/ingredients/vitamin-a) and [palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/palmitoyl-pentapeptide-4) apart in your routine because combining them may increase irritation, so you should alternate usage by applying a retinoid in the PM and peptides in the AM.

### Which goes first, vitamin A or palmitoyl pentapeptide-4?

Keep vitamin A and palmitoyl pentapeptide-4 apart because combined stimulation may increase irritation, so use them at different times such as applying vitamin A in the evening and peptides in the morning.

### Are vitamin A and palmitoyl pentapeptide-4 good for sensitive skin?

Keep vitamin A and palmitoyl pentapeptide-4 apart because combined stimulation may increase irritation in sensitive skin. Alternate your usage by applying the retinoid in the PM and peptides in the AM.

## Research on vitamin A and palmitoyl pentapeptide-4

- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Vitamin A · International Journal of Cosmetic Science, 2017
- [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Vitamin A · The British Journal of Dermatology, 2019
- [Clinical Assessment of New Topical Cream Containing Two Essential Oils Combined with Tretinoin in the Treatment of Acne](https://pubmed.ncbi.nlm.nih.gov/32210603/) Vitamin A · Clinical, Cosmetic and Investigational Dermatology, 2020
- [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Vitamin A · International Journal of Nanomedicine, 2021
- [Encapsulation and controlled release of retinol from silicone particles for topical delivery](https://pubmed.ncbi.nlm.nih.gov/29604311/) Vitamin A · Journal of Controlled Release, 2018
- [A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen](https://pubmed.ncbi.nlm.nih.gov/20374604/) Vitamin A · The British Journal of Dermatology, 2010
- [Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system](https://pubmed.ncbi.nlm.nih.gov/21411295/) Vitamin A · Colloids and Surfaces. B, Biointerfaces, 2011
- [A clinicopathological study of the effects of topical retinyl propionate cream in skin photoageing](https://pubmed.ncbi.nlm.nih.gov/9894360/) Vitamin A · Clinical and Experimental Dermatology, 1998
- [The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites](https://pubmed.ncbi.nlm.nih.gov/23438139/) Vitamin A · Journal of Cosmetic Dermatology, 2013
- [Topical application of retinyl propionate, 4 hexyl resorcinol, and niacinamide reverses molecular and clinical features of ageing](https://pubmed.ncbi.nlm.nih.gov/38685700/) Vitamin A · International Journal of Cosmetic Science, 2024
- [Retinyl propionate and climbazole combination demonstrates clinical improvement to the appearance of hyperpigmentation and deep wrinkling with minimal irritation](https://pubmed.ncbi.nlm.nih.gov/28733999/) Vitamin A · International Journal of Cosmetic Science, 2017
- [Microneedling and Topical Retinyl Palmitate for Acne Scars: A Preliminary Split-Face Study with Placebo Control](https://pubmed.ncbi.nlm.nih.gov/41899112/) Vitamin A · Journal of Clinical Medicine, 2026
- [Use of a Serum With the Infinite Glow® Device Improves Signs of Facial Aging: A Split-Face Case Report Using VISIA Analysis](https://pubmed.ncbi.nlm.nih.gov/42500768/) Palmitoyl pentapeptide-4 · Cureus, 2026

## Other combinations

- Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/vitamin-a-and-acetyl-hexapeptide-3)
- Keep them apart: [Bio-placenta peptides and vitamin A](https://lovi.care/skincare/ie/ingredients/bio-placenta-peptides-and-vitamin-a)
- Keep them apart: [Vitamin A and collagen peptide](https://lovi.care/skincare/ie/ingredients/vitamin-a-and-collagen-peptide)
- Keep them apart: [Vitamin A and copper peptide](https://lovi.care/skincare/ie/ingredients/vitamin-a-and-copper-peptide)
- Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-vitamin-a)
- Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/vitamin-a-and-hexapeptide-9)
- Keep them apart: [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/adapalene-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Granactive retinoid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/granactive-retinoid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Hydroxypinacolone retinoate and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Pro-retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/pro-retinol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Retinal and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/retinal-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Retinoid blend and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/retinoid-blend-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/retinol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Tretinoin and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/tretinoin-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Vitamin A and palmitoyl tripeptide-1](https://lovi.care/skincare/ie/ingredients/vitamin-a-and-palmitoyl-tripeptide-1)
- Keep them apart: [Vitamin A and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/vitamin-a-and-peptide-rich-plasma)
- Keep them apart: [Vitamin A and triple peptide blend](https://lovi.care/skincare/ie/ingredients/vitamin-a-and-triple-peptide-blend)
- Work well together: [Liposome and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/liposome-and-palmitoyl-pentapeptide-4)
- Work well together: [Microcapsule and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/microcapsule-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Vitamin C and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/vitamin-c-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Niacinamide and vitamin A](https://lovi.care/skincare/ie/ingredients/niacinamide-and-vitamin-a)
- Work well together: [Betaine and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/betaine-and-palmitoyl-pentapeptide-4)
- Work well together: [Glycerin and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/glycerin-and-palmitoyl-pentapeptide-4)
- Work well together: [Hyaluronic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/hyaluronic-acid-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Niacinamide and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/niacinamide-and-palmitoyl-pentapeptide-4)
- Work well together: [Panthenol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/panthenol-and-palmitoyl-pentapeptide-4)
- Work well together: [Bakuchiol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/bakuchiol-and-palmitoyl-pentapeptide-4)
- Work well together: [Arginine and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/arginine-and-palmitoyl-pentapeptide-4)
- Work well together: [GABA and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/gaba-and-palmitoyl-pentapeptide-4)
- Work well together: [Silk amino acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/silk-amino-acids-and-palmitoyl-pentapeptide-4)
- Work well together: [Taurine and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/taurine-and-palmitoyl-pentapeptide-4)
- Work well together: [Palmitoyl pentapeptide-4 and theanine](https://lovi.care/skincare/ie/ingredients/palmitoyl-pentapeptide-4-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/aha-blend-glycolic-and-citric-acids-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Citric acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/citric-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Glycolic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/glycolic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Lactic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/lactic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Mandelic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/mandelic-acid-and-palmitoyl-pentapeptide-4)
- Work well together: [Coenzyme Q10 and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/coenzyme-q10-and-palmitoyl-pentapeptide-4)
- Work well together: [Green tea and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/green-tea-and-palmitoyl-pentapeptide-4)
- Work well together: [Vitamin E and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4)
- Work well together: [Beta-sitosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/beta-sitosterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Ceramide-building complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/ceramide-building-complex-and-palmitoyl-pentapeptide-4)
- Work well together: [Cholesterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/cholesterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Phytosphingosine and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/phytosphingosine-and-palmitoyl-pentapeptide-4)
- Work well together: [Phytosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/phytosterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Squalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/squalene-and-palmitoyl-pentapeptide-4)
- Work well together: [Tri-ceramide complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/tri-ceramide-complex-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Salicylic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/salicylic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Baking soda and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/baking-soda-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Bleach and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/bleach-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Potassium hydroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/potassium-hydroxide-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Behenyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/behenyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Isopropyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/isopropyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Polyvinyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/polyvinyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Copper and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/copper-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Benzoyl peroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/benzoyl-peroxide-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Magnesium and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/magnesium-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Zinc and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/zinc-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Zinc sulfate and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/zinc-sulfate-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Azelaic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Protease and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/protease-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Superoxide dismutase and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4
- United Kingdom: https://lovi.care/skincare/uk/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4
- Ireland: https://lovi.care/skincare/ie/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4 (this page)
- Germany: https://lovi.care/skincare/de/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4
- France: https://lovi.care/skincare/fr/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4
- Italy: https://lovi.care/skincare/it/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4
- Netherlands: https://lovi.care/skincare/nl/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4
- Spain: https://lovi.care/skincare/es/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4
- Canada: https://lovi.care/skincare/ca/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4
- Australia: https://lovi.care/skincare/au/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4
- Singapore: https://lovi.care/skincare/sg/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4