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Retinol and mandelic acid

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Retinol and mandelic acid: keep them apart

Keep them apart

Use retinol and mandelic acid on alternate nights to prevent skin irritation. Both ingredients speed up skin cell renewal, so combining them can cause redness and peeling. The shopper can use a gentler product strength or leave more days between using each ingredient.

Photocarcinogenesis study of glycolic acid and salicylic acid (CAS Nos. 79-14-1 and 69-72-7) in SKH-1 mice (simulated solar light and topical application study)Novel retinoid ester in combination with salicylic acid for the treatment of acne

Retinol products

Mandelic acid products

Questions and answers

Can you use retinol and mandelic acid together?

Keep retinol and mandelic acid apart in your routine to help avoid over-exfoliation and irritation. Instead, try alternating them on different evenings or buffer them with a moisturizer.

Which goes first, retinol or mandelic acid?

Keep retinol and mandelic acid apart in your routine to avoid over-exfoliation and irritation. You can safely use them by alternating evenings or buffering with a moisturizer between uses.

Are retinol and mandelic acid good for sensitive skin?

Keep retinol and mandelic acid apart to avoid over-exfoliation and irritation on sensitive skin. Instead, alternate them on different evenings or buffer them with a moisturizer.

Research on retinol and mandelic acid

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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