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Retinal and acetyl hexapeptide-3

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Retinal and acetyl hexapeptide-3: keep them apart

Keep them apart

Use them at different times of day, applying retinal at night and acetyl hexapeptide-3 in the morning to avoid skin irritation. Both ingredients work hard to smooth the skin, but mixing them at the same time can cause redness and stinging. You can easily fix this by using a gentler strength or simply applying them at different times of the day.

Retinal products

Acetyl hexapeptide-3 products

Questions and answers

Can you use retinal and acetyl hexapeptide-3 together?

No, you should keep retinal and acetyl hexapeptide-3 apart in your routine because combined stimulation may increase irritation. Instead, alternate your usage by applying your retinoid in the evening and peptides in the morning.

Which goes first, retinal or acetyl hexapeptide-3?

Keep retinal and acetyl hexapeptide-3 apart in your routine because combined stimulation may increase irritation. Alternate usage by applying your retinoid in the evening and peptides in the morning.

Are retinal and acetyl hexapeptide-3 good for sensitive skin?

No, you should keep retinal and acetyl hexapeptide-3 apart in your routine because combined stimulation may increase irritation on sensitive skin. Instead, you can alternate usage by applying your retinal in the evening and your peptides in the morning.

Research on retinal and acetyl hexapeptide-3

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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