# Hexapeptide and retinal Page: https://lovi.care/skincare/ie/ingredients/hexapeptide-and-retinal The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland. Keep them apart Use them at different times of day, applying [retinal](https://lovi.care/skincare/ie/ingredients/retinal) at night and [hexapeptide](https://lovi.care/skincare/ie/ingredients/hexapeptide) in the morning, to prevent skin irritation. Both ingredients work hard to smooth the skin, and mixing them at the same time can cause redness and stinging. The shopper can switch to a gentler strength or separate the application times to keep the skin calm and comfortable. - [All about hexapeptide](https://lovi.care/skincare/ie/ingredients/hexapeptide) - [All about retinal](https://lovi.care/skincare/ie/ingredients/retinal) ### [Hexapeptide](https://lovi.care/skincare/ie/ingredients/hexapeptide) products - [SkinCeuticals P-TOX](https://lovi.care/skincare/ie/p/skinceuticals/p-tox/for/mature-skin) — High fit — [€155.25 at Lookfantastic](https://www.lookfantastic.ie/p/skinceuticals-p-tiox-neuro-peptide-serum-30ml/15456548/) ### [Retinal](https://lovi.care/skincare/ie/ingredients/retinal) products - [Beauty of Joseon Revive Eye Serum](https://lovi.care/skincare/ie/p/beauty-of-joseon/revive-eye-serum/for/combination-skin) — High fit — [€12.98 at Amazon](https://www.amazon.ie/dp/B0B45LL4DD?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [The Ordinary Retinal 0.2% Emulsion](https://lovi.care/skincare/ie/p/the-ordinary/retinal-0-2-emulsion/for/oily-acne-prone-skin) — High fit — [€14.57 at Amazon](https://www.amazon.ie/dp/B0CZ5VG3L1?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [Medik8 CRYSTAL RETINAL 3](https://lovi.care/skincare/ie/p/medik8/crystal-retinal-3/for/mature-skin) — High fit — [€46.00 at Lookfantastic](https://www.lookfantastic.ie/p/medik8-crystal-retinal-3-serum-30ml/12097972/) - [Murad Retinal ReSculpt Overnight Treatment](https://lovi.care/skincare/ie/p/murad/retinal-resculpt-overnight-treatment/for/mature-skin) — Superior fit — [€91.92 at Amazon](https://www.amazon.ie/dp/B0FJW4K9HR?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [celimax RETINAL SHOT](https://lovi.care/skincare/ie/p/celimax/retinal-shot/for/acne-prone-skin) — Average fit — [€21.28 at Amazon](https://www.amazon.ie/dp/B0DK4Y2YP3?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [Some By Mi Retinol Intense Reactivating Serum](https://lovi.care/skincare/ie/p/some-by-mi/retinol-intense-reactivating-serum/for/oily-acne-prone-skin) — High fit — [€13.50 at Notino](https://www.notino.ie/some-by-mi/retinol-intense-anti-wrinkle-retinol-serum-for-sensitive-skin/p-16293218/) - [NATURIUM Retinaldehyde Cream Serum 0.05%](https://lovi.care/skincare/ie/p/naturium/retinaldehyde-cream-serum-0-05/for/dry-skin) — Average fit — [€37.82 at Amazon](https://www.amazon.ie/dp/B0DJFX5PS6?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [Avène RetrinAL EYES](https://lovi.care/skincare/ie/p/avene/retrinal-eyes/for/dry-skin) — High fit - [Murad Retinal ReSculpt Body Treatment](https://lovi.care/skincare/ie/p/murad/retinal-resculpt-body-treatment/for/mature-skin) — Average fit - [K-SECRET SEOUl 1988 EYE CREAM](https://lovi.care/skincare/ie/p/k-secret/seoul-1988-eye-cream/for/mature-skin) — Average fit — [€18.50 at Amazon](https://www.amazon.ie/dp/B0DGGBYDRZ?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [Geek & Gorgeous A-Game 5](https://lovi.care/skincare/ie/p/geek-and-gorgeous/a-game-5/for/oily-acne-prone-skin) — High fit — [€15.80 at Amazon](https://www.amazon.ie/dp/B08TTP8589?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [Peach & Lily Retinal For All Renewing Serum](https://lovi.care/skincare/ie/p/peach-and-lily/retinal-for-all-renewing-serum/for/dry-sensitive-skin) — Average fit ## Questions and answers ### Can you use hexapeptide and retinal together? You should keep [hexapeptide](https://lovi.care/skincare/ie/ingredients/hexapeptide) and [retinal](https://lovi.care/skincare/ie/ingredients/retinal) apart in your routine because combining them may increase irritation. Instead, alternate their usage by applying retinal at night and peptides in the morning. ### Which goes first, hexapeptide or retinal? Keep hexapeptide and retinal apart in your routine by using retinal in the PM and hexapeptide in the AM to help avoid increased irritation. ### Are hexapeptide and retinal good for sensitive skin? Hexapeptide and retinal are not recommended for the same routine because combined stimulation may increase irritation on sensitive skin. Instead, you can use retinal in the evening and hexapeptide in the morning. ## Research on hexapeptide and retinal - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013 - [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019 ## Other combinations - Keep them apart: [Retinal and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/retinal-and-acetyl-hexapeptide-3) - Keep them apart: [Bio-placenta peptides and retinal](https://lovi.care/skincare/ie/ingredients/bio-placenta-peptides-and-retinal) - Keep them apart: [Retinal and collagen peptide](https://lovi.care/skincare/ie/ingredients/retinal-and-collagen-peptide) - Keep them apart: [Retinal and copper peptide](https://lovi.care/skincare/ie/ingredients/retinal-and-copper-peptide) - Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/ie/ingredients/adapalene-and-hexapeptide) - Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-granactive-retinoid) - Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-hydroxypinacolone-retinoate) - Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-pro-retinol) - Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-retinoid-blend) - Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/ie/ingredients/retinol-and-hexapeptide) - Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/ie/ingredients/tretinoin-and-hexapeptide) - Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-vitamin-a) - Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/retinal-and-hexapeptide-9) - Keep them apart: [Retinal and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/retinal-and-palmitoyl-pentapeptide-4) - Keep them apart: [Retinal and palmitoyl tripeptide-1](https://lovi.care/skincare/ie/ingredients/retinal-and-palmitoyl-tripeptide-1) - Keep them apart: [Retinal and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/retinal-and-peptide-rich-plasma) - Keep them apart: [Retinal and triple peptide blend](https://lovi.care/skincare/ie/ingredients/retinal-and-triple-peptide-blend) - Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-liposome) - Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-microcapsule) - Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/ie/ingredients/vitamin-c-and-hexapeptide) - Depends on the strength: [Niacinamide and retinal](https://lovi.care/skincare/ie/ingredients/niacinamide-and-retinal) - Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-betaine) - Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/ie/ingredients/glycerin-and-hexapeptide) - Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/ie/ingredients/niacinamide-and-hexapeptide) - Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/ie/ingredients/panthenol-and-hexapeptide) - Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/ie/ingredients/bakuchiol-and-hexapeptide) - Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-arginine) - Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-gaba) - Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-silk-amino-acids) - Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-taurine) - Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/ie/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide) - Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-citric-acid) - Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/ie/ingredients/glycolic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-lactic-acid) - Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-mandelic-acid) - Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/ie/ingredients/coenzyme-q10-and-hexapeptide) - Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/ie/ingredients/green-tea-and-hexapeptide) - Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/ie/ingredients/vitamin-e-and-hexapeptide) - Keep them apart: [AHA blend glycolic and citric acids and retinal](https://lovi.care/skincare/ie/ingredients/aha-blend-glycolic-and-citric-acids-and-retinal) - Keep them apart: [Retinal and citric acid](https://lovi.care/skincare/ie/ingredients/retinal-and-citric-acid) - Keep them apart: [Glycolic acid and retinal](https://lovi.care/skincare/ie/ingredients/glycolic-acid-and-retinal) - Keep them apart: [Retinal and lactic acid](https://lovi.care/skincare/ie/ingredients/retinal-and-lactic-acid) - Keep them apart: [Retinal and mandelic acid](https://lovi.care/skincare/ie/ingredients/retinal-and-mandelic-acid) - Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/ie/ingredients/ceramide-building-complex-and-hexapeptide) - Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-cholesterol) - Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-phytosphingosine) - Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-phytosterol) - Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-squalene) - Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/ie/ingredients/salicylic-acid-and-hexapeptide) - Keep them apart: [Salicylic acid and retinal](https://lovi.care/skincare/ie/ingredients/salicylic-acid-and-retinal) - Keep them apart: [Vitamin C and retinal](https://lovi.care/skincare/ie/ingredients/vitamin-c-and-retinal) - Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-baking-soda) - Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-bleach) - Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-potassium-hydroxide) - Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-behenyl-alcohol) - Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-isopropyl-alcohol) - Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-polyvinyl-alcohol) - Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-copper) - Keep them apart: [Benzoyl peroxide and retinal](https://lovi.care/skincare/ie/ingredients/benzoyl-peroxide-and-retinal) - Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-magnesium) - Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-zinc) - Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/ie/ingredients/benzoyl-peroxide-and-hexapeptide) - Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/ie/ingredients/azelaic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-protease) - Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/hexapeptide-and-retinal - United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-and-retinal - Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-and-retinal (this page) - Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-and-retinal - France: https://lovi.care/skincare/fr/ingredients/hexapeptide-and-retinal - Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-and-retinal - Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-and-retinal - Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-and-retinal - Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-and-retinal - Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-and-retinal - Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-and-retinal - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-and-retinal - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-and-retinal