# Betaine and hexapeptide-9

Page: https://lovi.care/skincare/ie/ingredients/betaine-and-hexapeptide-9

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Work well together

Use them together by applying your [betaine](https://lovi.care/skincare/ie/ingredients/betaine) product first and your [hexapeptide-9](https://lovi.care/skincare/ie/ingredients/hexapeptide-9) product second, because hydration helps the peptide work better. Betaine draws moisture into your skin while hexapeptide-9 helps smooth and firm the surface, creating a great team for your complexion. You do not need to change anything since this combination is gentle and effective.

[Effects of water activity and low molecular weight humectants on skin permeability and hydration dynamics - a double-blind, randomized and controlled study](https://pubmed.ncbi.nlm.nih.gov/24786192/) [The efficiency of humectants as skin moisturizers in the presence of oil](https://pubmed.ncbi.nlm.nih.gov/11301638/)

- [All about betaine](https://lovi.care/skincare/ie/ingredients/betaine)
- [All about hexapeptide-9](https://lovi.care/skincare/ie/ingredients/hexapeptide-9)

### [Betaine](https://lovi.care/skincare/ie/ingredients/betaine) products

- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/ie/p/cosrx/advanced-snail-96-mucin-power-essence/for/dry-skin) — Superior fit — [€14.07 at Amazon](https://www.amazon.ie/dp/B00PBX3L7K?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [COSRX The Hyaluronic Acid 3 Serum](https://lovi.care/skincare/ie/p/cosrx/the-hyaluronic-acid-3-serum/for/combination-skin) — High fit — [€17.00 at Amazon](https://www.amazon.ie/dp/B09ZYCVH8N?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Good Molecules Niacinamide Serum](https://lovi.care/skincare/ie/p/good-molecules/niacinamide-serum/for/oily-skin) — Average fit — [€18.88 at Amazon](https://www.amazon.ie/dp/B08R994Q1L?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [COSRX Advanced Snail 92 All in One Cream](https://lovi.care/skincare/ie/p/cosrx/advanced-snail-92-all-in-one-cream/for/sensitive-skin) — Superior fit — [€22.87 at Amazon](https://www.amazon.ie/dp/B01LEJ5MSK?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [MEDIHEAL Collagen Ampoule Pad](https://lovi.care/skincare/ie/p/mediheal/collagen-ampoule-pad/for/mature-skin) — High fit — [€23.09 at Amazon](https://www.amazon.ie/dp/B0BHVF95S9?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [PanOxyl Clarifying Exfoliant](https://lovi.care/skincare/ie/p/panoxyl/clarifying-exfoliant/for/combination-skin) — High fit — [€20.53 at Amazon](https://www.amazon.ie/dp/B0CPQ9S5J8?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Anua Heartleaf 77% Clear Pad](https://lovi.care/skincare/ie/p/anua/heartleaf-77-clear-pad/for/sensitive-skin) — High fit — [€25.04 at Amazon](https://www.amazon.ie/dp/B08JLMRTZS?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [innisfree Cherry Blossom Glow Jelly Cream](https://lovi.care/skincare/ie/p/innisfree/cherry-blossom-glow-jelly-cream/for/dry-skin) — Average fit — [€30.90 at Amazon](https://www.amazon.ie/dp/B0F3HGKWN7?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [The INKEY List Omega Water Cream](https://lovi.care/skincare/ie/p/the-inkey-list/omega-water-cream/for/dry-skin) — High fit — [€9.49 at Amazon](https://www.amazon.ie/dp/B09XY514HX?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Illiyoon Ceramide Ato Soothing Gel](https://lovi.care/skincare/ie/p/illiyoon/ceramide-ato-soothing-gel/for/acne-prone-skin) — High fit
- [COSRX Advanced Snail Mucin Power Sheet Mask](https://lovi.care/skincare/ie/p/cosrx/advanced-snail-mucin-power-sheet-mask/for/dry-skin) — Superior fit — [€4.40 at Notino](https://www.notino.ie/cosrx/advanced-snail-power-essence-anti-wrinkle-cloth-mask-with-moisturising-effect/p-16373127/)
- [AMOREPACIFIC Treatment Enzyme Peel](https://lovi.care/skincare/ie/p/amorepacific/treatment-enzyme-peel/for/dark-spots) — Superior fit

### [Hexapeptide-9](https://lovi.care/skincare/ie/ingredients/hexapeptide-9) products

- [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/ie/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [€102.00 at Notino](https://www.notino.ie/elemis/pro-collagen-oxygenating-night-cream-firming-anti-wrinkle-night-cream/p-16327257/)
- [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/ie/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit
- [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/ie/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [€17.26 at Amazon](https://www.amazon.ie/dp/B095YHYF33?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use betaine and hexapeptide-9 together?

Yes, you can use [betaine](https://lovi.care/skincare/ie/ingredients/betaine) and [hexapeptide-9](https://lovi.care/skincare/ie/ingredients/hexapeptide-9) together because humectants like betaine pair well with peptides to enhance hydration and improve peptide delivery. Lovi gives this combination a High fit for all skin types, especially dry and mature skin.

### Which goes first, betaine or hexapeptide-9?

Layer a hydrating [serum](https://lovi.care/skincare/ie/ingredients/serum) containing betaine beneath your hexapeptide-9 product to increase peptide diffusion and support skin barrier integrity.

### Are betaine and hexapeptide-9 good for sensitive skin?

Yes, betaine and hexapeptide-9 work well together to benefit all skin types by enhancing hydration and supporting barrier integrity. You can combine them by layering a hydrating serum beneath your peptide product.

## Research on betaine and hexapeptide-9

- [Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration](https://pubmed.ncbi.nlm.nih.gov/38611819/) Betaine · Molecules, 2024
- [Formulation of Ascorbic Acid and Betaine-based Therapeutic Deep Eutectic System for Enhanced Transdermal Delivery of Ascorbic Acid](https://pubmed.ncbi.nlm.nih.gov/38794349/) Betaine · Pharmaceutics, 2024
- [The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively](https://pubmed.ncbi.nlm.nih.gov/12535284/) Betaine · Skin Research and Technology, 2003
- [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025

## Other combinations

- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/granactive-retinoid-and-hexapeptide-9)
- Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9)
- Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/pro-retinol-and-hexapeptide-9)
- Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/retinal-and-hexapeptide-9)
- Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/retinoid-blend-and-hexapeptide-9)
- Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/retinol-and-hexapeptide-9)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/vitamin-a-and-hexapeptide-9)
- Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/liposome-and-hexapeptide-9)
- Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/microcapsule-and-hexapeptide-9)
- Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/vitamin-c-and-hexapeptide-9)
- Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-betaine)
- Work well together: [Bio-placenta peptides and betaine](https://lovi.care/skincare/ie/ingredients/bio-placenta-peptides-and-betaine)
- Work well together: [Collagen peptide and betaine](https://lovi.care/skincare/ie/ingredients/collagen-peptide-and-betaine)
- Work well together: [Betaine and copper peptide](https://lovi.care/skincare/ie/ingredients/betaine-and-copper-peptide)
- Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-betaine)
- Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/glycerin-and-hexapeptide-9)
- Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/hyaluronic-acid-and-hexapeptide-9)
- Work well together: [Betaine and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/betaine-and-palmitoyl-pentapeptide-4)
- Work well together: [Betaine and palmitoyl tripeptide-1](https://lovi.care/skincare/ie/ingredients/betaine-and-palmitoyl-tripeptide-1)
- Work well together: [Betaine and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/betaine-and-peptide-rich-plasma)
- Work well together: [Betaine and triple peptide blend](https://lovi.care/skincare/ie/ingredients/betaine-and-triple-peptide-blend)
- Work well together: [AHA blend glycolic and citric acids and betaine](https://lovi.care/skincare/ie/ingredients/aha-blend-glycolic-and-citric-acids-and-betaine)
- Work well together: [Betaine and citric acid](https://lovi.care/skincare/ie/ingredients/betaine-and-citric-acid)
- Work well together: [Glycolic acid and betaine](https://lovi.care/skincare/ie/ingredients/glycolic-acid-and-betaine)
- Work well together: [Lactic acid and betaine](https://lovi.care/skincare/ie/ingredients/lactic-acid-and-betaine)
- Work well together: [Mandelic acid and betaine](https://lovi.care/skincare/ie/ingredients/mandelic-acid-and-betaine)
- Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/niacinamide-and-hexapeptide-9)
- Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/panthenol-and-hexapeptide-9)
- Work well together: [Betaine and tri-ceramide complex](https://lovi.care/skincare/ie/ingredients/betaine-and-tri-ceramide-complex)
- Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/bakuchiol-and-hexapeptide-9)
- Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/arginine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-gaba)
- Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/silk-amino-acids-and-hexapeptide-9)
- Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/taurine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9)
- Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/citric-acid-and-hexapeptide-9)
- Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/glycolic-acid-and-hexapeptide-9)
- Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/lactic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/mandelic-acid-and-hexapeptide-9)
- Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/coenzyme-q10-and-hexapeptide-9)
- Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/green-tea-and-hexapeptide-9)
- Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/vitamin-e-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/ceramide-building-complex-and-hexapeptide-9)
- Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/cholesterol-and-hexapeptide-9)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/phytosterol-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-squalene)
- Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/salicylic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-baking-soda)
- Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/bleach-and-hexapeptide-9)
- Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/potassium-hydroxide-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/polyvinyl-alcohol-and-hexapeptide-9)
- Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/copper-and-hexapeptide-9)
- Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/benzoyl-peroxide-and-hexapeptide-9)
- Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/magnesium-and-hexapeptide-9)
- Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/zinc-and-hexapeptide-9)
- Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/zinc-sulfate-and-hexapeptide-9)
- Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/azelaic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-protease)
- Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/superoxide-dismutase-and-hexapeptide-9)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/betaine-and-hexapeptide-9
- United Kingdom: https://lovi.care/skincare/uk/ingredients/betaine-and-hexapeptide-9
- Ireland: https://lovi.care/skincare/ie/ingredients/betaine-and-hexapeptide-9 (this page)
- Germany: https://lovi.care/skincare/de/ingredients/betaine-and-hexapeptide-9
- France: https://lovi.care/skincare/fr/ingredients/betaine-and-hexapeptide-9
- Italy: https://lovi.care/skincare/it/ingredients/betaine-and-hexapeptide-9
- Netherlands: https://lovi.care/skincare/nl/ingredients/betaine-and-hexapeptide-9
- Spain: https://lovi.care/skincare/es/ingredients/betaine-and-hexapeptide-9
- Canada: https://lovi.care/skincare/ca/ingredients/betaine-and-hexapeptide-9
- Australia: https://lovi.care/skincare/au/ingredients/betaine-and-hexapeptide-9
- Singapore: https://lovi.care/skincare/sg/ingredients/betaine-and-hexapeptide-9
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/betaine-and-hexapeptide-9
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/betaine-and-hexapeptide-9