# Arginine and hexapeptide-9

Page: https://lovi.care/skincare/ie/ingredients/arginine-and-hexapeptide-9

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Work well together

Use them together in the same routine, applying the amino acid first and the peptide right after. [Arginine](https://lovi.care/skincare/ie/ingredients/arginine) helps deliver moisture and nourishment, while [hexapeptide-9](https://lovi.care/skincare/ie/ingredients/hexapeptide-9) supports firmer, healthier-looking skin. You can continue using both together, but if your skin feels sensitive, try applying them on alternate nights or look for gentler formulas.

- [All about arginine](https://lovi.care/skincare/ie/ingredients/arginine)
- [All about hexapeptide-9](https://lovi.care/skincare/ie/ingredients/hexapeptide-9)

### [Arginine](https://lovi.care/skincare/ie/ingredients/arginine) products

- [SKIN AQUA UV Super Moisture Gel](https://lovi.care/skincare/ie/p/skin-aqua/uv-super-moisture-gel/for/oily-skin) — Superior fit
- [SKIN AQUA UV Super Moisture Milk](https://lovi.care/skincare/ie/p/skin-aqua/uv-super-moisture-milk/for/dark-spots) — High fit
- [NIOD Superoxide Dismutase Saccharide Mist](https://lovi.care/skincare/ie/p/niod/superoxide-dismutase-saccharide-mist/for/dry-sensitive-skin) — Average fit
- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/ie/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/oily-acne-prone-skin) — Superior fit — [€6.00 at Notino](https://www.notino.ie/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97-intensely-hydrating-serum-with-hyaluronic-acid/p-16191539/)
- [S.Nature Aqua Squalane Moisturizing Cream](https://lovi.care/skincare/ie/p/s-nature/aqua-squalane-moisturizing-cream/for/dry-skin) — Superior fit — [€20.50 at Amazon](https://www.amazon.ie/dp/B09KV5LCVH?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)

### [Hexapeptide-9](https://lovi.care/skincare/ie/ingredients/hexapeptide-9) products

- [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/ie/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [€102.00 at Notino](https://www.notino.ie/elemis/pro-collagen-oxygenating-night-cream-firming-anti-wrinkle-night-cream/p-16327257/)
- [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/ie/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit
- [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/ie/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [€17.26 at Amazon](https://www.amazon.ie/dp/B095YHYF33?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use arginine and hexapeptide-9 together?

Yes, you can use [arginine](https://lovi.care/skincare/ie/ingredients/arginine) and [hexapeptide-9](https://lovi.care/skincare/ie/ingredients/hexapeptide-9) together because they support structural protein synthesis and moisture balance, making them beneficial when paired in hydrating and reparative complexes for all skin types.

[Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40586182/)

### Which goes first, arginine or hexapeptide-9?

Arginine and hexapeptide-9 work well together to support structural protein synthesis and moisture balance, so you can use them in hydrating and reparative complexes for all skin types.

### Are arginine and hexapeptide-9 good for sensitive skin?

Arginine and hexapeptide-9 work well together to support structural protein synthesis and moisture balance for all skin types. Lovi gives this combination a High fit.

## Research on arginine and hexapeptide-9

- [Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos](https://pubmed.ncbi.nlm.nih.gov/39769217/) Arginine · International Journal of Molecular Sciences, 2024
- [A cleanser formulated with Tris (hydroxymethyl) aminomethane and l-arginine significantly improves facial acne in male Thai subjects](https://pubmed.ncbi.nlm.nih.gov/31347768/) Arginine · Journal of Cosmetic Dermatology, 2020
- [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025

## Other combinations

- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/granactive-retinoid-and-hexapeptide-9)
- Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9)
- Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/pro-retinol-and-hexapeptide-9)
- Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/retinal-and-hexapeptide-9)
- Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/retinoid-blend-and-hexapeptide-9)
- Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/retinol-and-hexapeptide-9)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/vitamin-a-and-hexapeptide-9)
- Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/liposome-and-hexapeptide-9)
- Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/microcapsule-and-hexapeptide-9)
- Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/vitamin-c-and-hexapeptide-9)
- Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/betaine-and-hexapeptide-9)
- Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/glycerin-and-hexapeptide-9)
- Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/hyaluronic-acid-and-hexapeptide-9)
- Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/niacinamide-and-hexapeptide-9)
- Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/panthenol-and-hexapeptide-9)
- Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/bakuchiol-and-hexapeptide-9)
- Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/arginine-and-acetyl-hexapeptide-3)
- Work well together: [Bio-placenta peptides and arginine](https://lovi.care/skincare/ie/ingredients/bio-placenta-peptides-and-arginine)
- Work well together: [Arginine and collagen peptide](https://lovi.care/skincare/ie/ingredients/arginine-and-collagen-peptide)
- Work well together: [Arginine and copper peptide](https://lovi.care/skincare/ie/ingredients/arginine-and-copper-peptide)
- Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-arginine)
- Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-gaba)
- Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/silk-amino-acids-and-hexapeptide-9)
- Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/taurine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-theanine)
- Work well together: [Arginine and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/arginine-and-palmitoyl-pentapeptide-4)
- Work well together: [Arginine and palmitoyl tripeptide-1](https://lovi.care/skincare/ie/ingredients/arginine-and-palmitoyl-tripeptide-1)
- Work well together: [Arginine and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/arginine-and-peptide-rich-plasma)
- Work well together: [Arginine and triple peptide blend](https://lovi.care/skincare/ie/ingredients/arginine-and-triple-peptide-blend)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9)
- Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/citric-acid-and-hexapeptide-9)
- Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/glycolic-acid-and-hexapeptide-9)
- Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/lactic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/mandelic-acid-and-hexapeptide-9)
- Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/coenzyme-q10-and-hexapeptide-9)
- Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/green-tea-and-hexapeptide-9)
- Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/vitamin-e-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/ceramide-building-complex-and-hexapeptide-9)
- Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/cholesterol-and-hexapeptide-9)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/phytosterol-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-squalene)
- Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/salicylic-acid-and-hexapeptide-9)
- Work well together: [AHA blend glycolic and citric acids and arginine](https://lovi.care/skincare/ie/ingredients/aha-blend-glycolic-and-citric-acids-and-arginine)
- Work well together: [Arginine and citric acid](https://lovi.care/skincare/ie/ingredients/arginine-and-citric-acid)
- Work well together: [Glycolic acid and arginine](https://lovi.care/skincare/ie/ingredients/glycolic-acid-and-arginine)
- Work well together: [Arginine and lactic acid](https://lovi.care/skincare/ie/ingredients/arginine-and-lactic-acid)
- Work well together: [Arginine and mandelic acid](https://lovi.care/skincare/ie/ingredients/arginine-and-mandelic-acid)
- Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-baking-soda)
- Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/bleach-and-hexapeptide-9)
- Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/potassium-hydroxide-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/polyvinyl-alcohol-and-hexapeptide-9)
- Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/copper-and-hexapeptide-9)
- Work well together: [Arginine and hyaluronic acid](https://lovi.care/skincare/ie/ingredients/arginine-and-hyaluronic-acid)
- Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/benzoyl-peroxide-and-hexapeptide-9)
- Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/magnesium-and-hexapeptide-9)
- Keep them apart: [Zinc and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/zinc-and-hexapeptide-9)
- Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/zinc-sulfate-and-hexapeptide-9)
- Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/azelaic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/ie/ingredients/hexapeptide-9-and-protease)
- Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/superoxide-dismutase-and-hexapeptide-9)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/arginine-and-hexapeptide-9
- United Kingdom: https://lovi.care/skincare/uk/ingredients/arginine-and-hexapeptide-9
- Ireland: https://lovi.care/skincare/ie/ingredients/arginine-and-hexapeptide-9 (this page)
- Germany: https://lovi.care/skincare/de/ingredients/arginine-and-hexapeptide-9
- France: https://lovi.care/skincare/fr/ingredients/arginine-and-hexapeptide-9
- Italy: https://lovi.care/skincare/it/ingredients/arginine-and-hexapeptide-9
- Netherlands: https://lovi.care/skincare/nl/ingredients/arginine-and-hexapeptide-9
- Spain: https://lovi.care/skincare/es/ingredients/arginine-and-hexapeptide-9
- Canada: https://lovi.care/skincare/ca/ingredients/arginine-and-hexapeptide-9
- Australia: https://lovi.care/skincare/au/ingredients/arginine-and-hexapeptide-9
- Singapore: https://lovi.care/skincare/sg/ingredients/arginine-and-hexapeptide-9
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/arginine-and-hexapeptide-9
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/arginine-and-hexapeptide-9