# Adapalene and peptide-rich plasma Page: https://lovi.care/skincare/ie/ingredients/adapalene-and-peptide-rich-plasma The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland. Keep them apart Use them at different times of day by applying peptides in the morning and [adapalene](https://lovi.care/skincare/ie/ingredients/adapalene) at night, because combining them in the same routine causes irritation. Adapalene renews skin cells while peptides help firm the surface, but using both at once can overload your skin and cause redness. You can prevent this by switching to a gentler strength or waiting longer between applications. - [All about adapalene](https://lovi.care/skincare/ie/ingredients/adapalene) - [All about peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/peptide-rich-plasma) ### [Adapalene](https://lovi.care/skincare/ie/ingredients/adapalene) products - [Differin Gel](https://lovi.care/skincare/ie/p/differin/gel/for/oily-acne-prone-skin) — High fit — [€76.89 at Amazon](https://www.amazon.ie/dp/B07ZTN5N1V?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [Galderma Epiduo Gel](https://lovi.care/skincare/ie/p/galderma/epiduo-gel/for/acne-prone-skin) — High fit - [La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment](https://lovi.care/skincare/ie/p/la-roche-posay/effaclar-adapalene-gel-0-1-acne-treatment/for/oily-skin) — Superior fit ### [Peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/peptide-rich-plasma) products - [Eighth Day Regenerative Serum](https://lovi.care/skincare/ie/p/eighth-day/regenerative-serum/for/dry-sensitive-skin) — High fit ## Questions and answers ### Can you use adapalene and peptide-rich plasma together? No, you should keep [adapalene](https://lovi.care/skincare/ie/ingredients/adapalene) and [peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/peptide-rich-plasma) apart in your routine because combined stimulation may increase irritation. Instead, alternate their usage by applying adapalene in the PM and peptides in the AM. ### Which goes first, adapalene or peptide-rich plasma? Keep adapalene and peptide-rich plasma apart because combining them may increase skin irritation. You can alternate usage by applying your retinoid in the evening and peptides in the morning. ### Are adapalene and peptide-rich plasma good for sensitive skin? Keep adapalene and peptide-rich plasma apart because combining strong retinoids and peptides may increase irritation. Alternate your usage by applying the retinoid in the evening and peptides in the morning. ## Research on adapalene and peptide-rich plasma - [Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison](https://pubmed.ncbi.nlm.nih.gov/29549588/) Adapalene · American Journal of Clinical Dermatology, 2018 - [Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug](https://pubmed.ncbi.nlm.nih.gov/34674160/) Adapalene · American Journal of Clinical Dermatology, 2022 - [A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/34251536/) Adapalene · Archives of Dermatological Research, 2022 - [Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials](https://pubmed.ncbi.nlm.nih.gov/37656094/) Adapalene · Journal of the American Academy of Dermatology, 2023 ## Other combinations - Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/adapalene-and-acetyl-hexapeptide-3) - Keep them apart: [Adapalene and bio-placenta peptides](https://lovi.care/skincare/ie/ingredients/adapalene-and-bio-placenta-peptides) - Keep them apart: [Adapalene and collagen peptide](https://lovi.care/skincare/ie/ingredients/adapalene-and-collagen-peptide) - Keep them apart: [Adapalene and copper peptide](https://lovi.care/skincare/ie/ingredients/adapalene-and-copper-peptide) - Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/ie/ingredients/adapalene-and-hexapeptide) - Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/adapalene-and-hexapeptide-9) - Keep them apart: [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/adapalene-and-palmitoyl-pentapeptide-4) - Keep them apart: [Adapalene and palmitoyl tripeptide-1](https://lovi.care/skincare/ie/ingredients/adapalene-and-palmitoyl-tripeptide-1) - Keep them apart: [Granactive retinoid and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/granactive-retinoid-and-peptide-rich-plasma) - Keep them apart: [Hydroxypinacolone retinoate and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/hydroxypinacolone-retinoate-and-peptide-rich-plasma) - Keep them apart: [Pro-retinol and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/pro-retinol-and-peptide-rich-plasma) - Keep them apart: [Retinal and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/retinal-and-peptide-rich-plasma) - Keep them apart: [Retinoid blend and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/retinoid-blend-and-peptide-rich-plasma) - Depends on the strength: [Retinol and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/retinol-and-peptide-rich-plasma) - Keep them apart: [Tretinoin and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/tretinoin-and-peptide-rich-plasma) - Keep them apart: [Vitamin A and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/vitamin-a-and-peptide-rich-plasma) - Keep them apart: [Adapalene and triple peptide blend](https://lovi.care/skincare/ie/ingredients/adapalene-and-triple-peptide-blend) - Work well together: [Liposome and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/liposome-and-peptide-rich-plasma) - Work well together: [Microcapsule and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/microcapsule-and-peptide-rich-plasma) - Keep them apart: [Vitamin C and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/vitamin-c-and-peptide-rich-plasma) - Depends on the strength: [Adapalene and niacinamide](https://lovi.care/skincare/ie/ingredients/adapalene-and-niacinamide) - Work well together: [Betaine and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/betaine-and-peptide-rich-plasma) - Work well together: [Glycerin and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/glycerin-and-peptide-rich-plasma) - Work well together: [Hyaluronic acid and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/hyaluronic-acid-and-peptide-rich-plasma) - Depends on the strength: [Niacinamide and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/niacinamide-and-peptide-rich-plasma) - Work well together: [Panthenol and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/panthenol-and-peptide-rich-plasma) - Work well together: [Bakuchiol and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/bakuchiol-and-peptide-rich-plasma) - Work well together: [Arginine and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/arginine-and-peptide-rich-plasma) - Work well together: [Peptide-rich plasma and GABA](https://lovi.care/skincare/ie/ingredients/peptide-rich-plasma-and-gaba) - Work well together: [Silk amino acids and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/silk-amino-acids-and-peptide-rich-plasma) - Work well together: [Taurine and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/taurine-and-peptide-rich-plasma) - Work well together: [Peptide-rich plasma and theanine](https://lovi.care/skincare/ie/ingredients/peptide-rich-plasma-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/aha-blend-glycolic-and-citric-acids-and-peptide-rich-plasma) - Keep them apart: [Citric acid and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/citric-acid-and-peptide-rich-plasma) - Keep them apart: [Glycolic acid and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/glycolic-acid-and-peptide-rich-plasma) - Keep them apart: [Lactic acid and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/lactic-acid-and-peptide-rich-plasma) - Keep them apart: [Mandelic acid and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/mandelic-acid-and-peptide-rich-plasma) - Work well together: [Coenzyme Q10 and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/coenzyme-q10-and-peptide-rich-plasma) - Work well together: [Green tea and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/green-tea-and-peptide-rich-plasma) - Work well together: [Vitamin E and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/vitamin-e-and-peptide-rich-plasma) - Keep them apart: [Adapalene and aha blend glycolic and citric acids](https://lovi.care/skincare/ie/ingredients/adapalene-and-aha-blend-glycolic-and-citric-acids) - Keep them apart: [Adapalene and citric acid](https://lovi.care/skincare/ie/ingredients/adapalene-and-citric-acid) - Keep them apart: [Adapalene and glycolic acid](https://lovi.care/skincare/ie/ingredients/adapalene-and-glycolic-acid) - Keep them apart: [Adapalene and lactic acid](https://lovi.care/skincare/ie/ingredients/adapalene-and-lactic-acid) - Keep them apart: [Adapalene and mandelic acid](https://lovi.care/skincare/ie/ingredients/adapalene-and-mandelic-acid) - Work well together: [Beta-sitosterol and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/beta-sitosterol-and-peptide-rich-plasma) - Work well together: [Ceramide-building complex and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/ceramide-building-complex-and-peptide-rich-plasma) - Work well together: [Cholesterol and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/cholesterol-and-peptide-rich-plasma) - Work well together: [Phytosphingosine and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/phytosphingosine-and-peptide-rich-plasma) - Work well together: [Phytosterol and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/phytosterol-and-peptide-rich-plasma) - Work well together: [Peptide-rich plasma and squalene](https://lovi.care/skincare/ie/ingredients/peptide-rich-plasma-and-squalene) - Work well together: [Peptide-rich plasma and tri-ceramide complex](https://lovi.care/skincare/ie/ingredients/peptide-rich-plasma-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/salicylic-acid-and-peptide-rich-plasma) - Keep them apart: [Adapalene and salicylic acid](https://lovi.care/skincare/ie/ingredients/adapalene-and-salicylic-acid) - Keep them apart: [Adapalene and vitamin C](https://lovi.care/skincare/ie/ingredients/adapalene-and-vitamin-c) - Keep them apart: [Peptide-rich plasma and baking soda](https://lovi.care/skincare/ie/ingredients/peptide-rich-plasma-and-baking-soda) - Keep them apart: [Bleach and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/bleach-and-peptide-rich-plasma) - Keep them apart: [Potassium hydroxide and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/potassium-hydroxide-and-peptide-rich-plasma) - Keep them apart: [Peptide-rich plasma and behenyl alcohol](https://lovi.care/skincare/ie/ingredients/peptide-rich-plasma-and-behenyl-alcohol) - Keep them apart: [Isopropyl alcohol and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/isopropyl-alcohol-and-peptide-rich-plasma) - Keep them apart: [Polyvinyl alcohol and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/polyvinyl-alcohol-and-peptide-rich-plasma) - Keep them apart: [Copper and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/copper-and-peptide-rich-plasma) - Keep them apart: [Adapalene and benzoyl peroxide](https://lovi.care/skincare/ie/ingredients/adapalene-and-benzoyl-peroxide) - Keep them apart: [Magnesium and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/magnesium-and-peptide-rich-plasma) - Keep them apart: [Zinc and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/zinc-and-peptide-rich-plasma) - Keep them apart: [Zinc sulfate and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/zinc-sulfate-and-peptide-rich-plasma) - Keep them apart: [Benzoyl peroxide and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/benzoyl-peroxide-and-peptide-rich-plasma) - Keep them apart: [Azelaic acid and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/azelaic-acid-and-peptide-rich-plasma) - Keep them apart: [Peptide-rich plasma and protease](https://lovi.care/skincare/ie/ingredients/peptide-rich-plasma-and-protease) - Keep them apart: [Superoxide dismutase and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/superoxide-dismutase-and-peptide-rich-plasma) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/adapalene-and-peptide-rich-plasma - United Kingdom: https://lovi.care/skincare/uk/ingredients/adapalene-and-peptide-rich-plasma - Ireland: https://lovi.care/skincare/ie/ingredients/adapalene-and-peptide-rich-plasma (this page) - Germany: https://lovi.care/skincare/de/ingredients/adapalene-and-peptide-rich-plasma - France: https://lovi.care/skincare/fr/ingredients/adapalene-and-peptide-rich-plasma - Italy: https://lovi.care/skincare/it/ingredients/adapalene-and-peptide-rich-plasma - Netherlands: https://lovi.care/skincare/nl/ingredients/adapalene-and-peptide-rich-plasma - Spain: https://lovi.care/skincare/es/ingredients/adapalene-and-peptide-rich-plasma - Canada: https://lovi.care/skincare/ca/ingredients/adapalene-and-peptide-rich-plasma - Australia: https://lovi.care/skincare/au/ingredients/adapalene-and-peptide-rich-plasma - Singapore: https://lovi.care/skincare/sg/ingredients/adapalene-and-peptide-rich-plasma - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/adapalene-and-peptide-rich-plasma - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/adapalene-and-peptide-rich-plasma