# Acetyl hexapeptide-3 and phytosphingosine Page: https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-phytosphingosine The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland. Work well together Use them together in the same routine, applying the peptide product first followed by the ceramide cream, for better barrier support. The [phytosphingosine](https://lovi.care/skincare/ie/ingredients/phytosphingosine) helps the [acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3) absorb better while reinforcing your skin structure for a smoother feel. You can keep using them together as long as your skin feels comfortable, or switch to using them on alternate days if you notice any sensitivity. - [All about acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3) - [All about phytosphingosine](https://lovi.care/skincare/ie/ingredients/phytosphingosine) ### [Acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3) products - [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/ie/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [€33.24 at Amazon](https://www.amazon.ie/dp/B0C9DXGXZ3?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/ie/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit — [€18.06 at Lookfantastic](https://www.lookfantastic.ie/p/the-ordinary-multi-peptide-ha-serum-30ml/13955445/) - [Medik8 Liquid Peptides](https://lovi.care/skincare/ie/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [€69.50 at Notino](https://www.notino.ie/medik8/liquid-peptides-anti-wrinkle-serum/p-16088423/) - [La Mer The Treatment Lotion](https://lovi.care/skincare/ie/p/la-mer/the-treatment-lotion/for/mature-skin) — Superior fit - [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/ie/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit - [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/ie/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit — [€8.82 at Amazon](https://www.amazon.ie/dp/B072JH13CD?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [Good Molecules Super Peptide Serum](https://lovi.care/skincare/ie/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [€24.66 at Amazon](https://www.amazon.ie/dp/B091MTKS35?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/ie/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit - [La Mer The Renewal Oil](https://lovi.care/skincare/ie/p/la-mer/the-renewal-oil/for/mature-skin) — High fit — [€225.26 at Amazon](https://www.amazon.ie/dp/B0163GAMI4?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/ie/p/estee-lauder/micro-essence-treatment-lotion/for/oily-acne-prone-skin) — Superior fit — [€87.32 at Amazon](https://www.amazon.ie/dp/B09Y3DG7WT?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/ie/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit - [La Mer The Eye Concentrate](https://lovi.care/skincare/ie/p/la-mer/the-eye-concentrate/for/mature-skin) — High fit — [€199.00 at Amazon](https://www.amazon.ie/dp/B085614WX5?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) ### [Phytosphingosine](https://lovi.care/skincare/ie/ingredients/phytosphingosine) products - [CeraVe Hydrating Facial Cleanser](https://lovi.care/skincare/ie/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — [€14.68 at Amazon](https://www.amazon.ie/dp/B07C5XPXDC?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/ie/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit — [€39.42 at Amazon](https://www.amazon.ie/dp/B0D9C55KBF?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [Aestura Atobarrier 365 Cream](https://lovi.care/skincare/ie/p/aestura/atobarrier-365-cream/for/dry-skin) — High fit — [€34.29 at Amazon](https://www.amazon.ie/dp/B0GXVFVQFW?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [Cetaphil Ceramide Serum](https://lovi.care/skincare/ie/p/cetaphil/ceramide-serum/for/acne-prone-skin) — Superior fit — [€32.99 at Amazon](https://www.amazon.ie/dp/B0957ZBGBJ?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [Bioderma Atoderm Intensive Eye](https://lovi.care/skincare/ie/p/bioderma/atoderm-intensive-eye/for/acne-prone-skin) — High fit — [€21.90 at Amazon](https://www.amazon.ie/dp/B08562FW67?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) - [Obagi Rebalance Skin Barrier Recovery Cream](https://lovi.care/skincare/ie/p/obagi/rebalance-skin-barrier-recovery-cream/for/dry-sensitive-skin) — High fit - [Elizabeth Arden Advanced Ceramide Capsules Daily Youth Restoring Serum](https://lovi.care/skincare/ie/p/elizabeth-arden/advanced-ceramide-capsules-daily-youth-restoring-serum/for/oily-skin) — High fit — [€34.95 at Amazon](https://www.amazon.ie/dp/B06WLQWXY6?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use acetyl hexapeptide-3 and phytosphingosine together? Yes, you can use [acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3) and [phytosphingosine](https://lovi.care/skincare/ie/ingredients/phytosphingosine) together because lipids like phytosphingosine improve peptide absorption and reinforce skin structure. Lovi rates this pairing as having High fit for dry, mature, and barrier-impaired skin. [Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/) ### Which goes first, acetyl hexapeptide-3 or phytosphingosine? Acetyl hexapeptide-3 and phytosphingosine work well together to repair and support the skin barrier, but the page facts do not specify which one goes first. ### Are acetyl hexapeptide-3 and phytosphingosine good for sensitive skin? Acetyl hexapeptide-3 and phytosphingosine work well together because the lipids help improve peptide absorption and reinforce skin structure. Lovi rates this combination as having a High fit for dry, mature, and barrier-impaired skin. [Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/) ## Research on acetyl hexapeptide-3 and phytosphingosine - [Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/18489348/) Phytosphingosine · International Journal of Cosmetic Science, 2007 - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-3 · Annals of Dermatology, 2019 - [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017 - [Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids](https://pubmed.ncbi.nlm.nih.gov/12482041/) Phytosphingosine · Journal of the European Academy of Dermatology and Venereology, 2002 - [Salicyloyl-phytosphingosine: a novel agent for the repair of photoaged skin](https://pubmed.ncbi.nlm.nih.gov/18489360/) Phytosphingosine · International Journal of Cosmetic Science, 2007 - [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013 ## Other combinations - Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/adapalene-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and granactive retinoid](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid) - Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate) - Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/pro-retinol-and-acetyl-hexapeptide-3) - Keep them apart: [Retinal and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/retinal-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-retinoid-blend) - Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/retinol-and-acetyl-hexapeptide-3) - Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/tretinoin-and-acetyl-hexapeptide-3) - Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/vitamin-a-and-acetyl-hexapeptide-3) - Work well together: [Liposome and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/liposome-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-microcapsule) - Depends on the strength: [Vitamin C and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/vitamin-c-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-betaine) - Work well together: [Glycerin and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/glycerin-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/niacinamide-and-acetyl-hexapeptide-3) - Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/panthenol-and-acetyl-hexapeptide-3) - Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/bakuchiol-and-acetyl-hexapeptide-3) - Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/arginine-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-gaba) - Work well together: [Silk amino acids and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3) - Work well together: [Taurine and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/taurine-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-citric-acid) - Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/glycolic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/lactic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-mandelic-acid) - Work well together: [Coenzyme Q10 and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3) - Work well together: [Green tea and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/green-tea-and-acetyl-hexapeptide-3) - Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/vitamin-e-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and beta-sitosterol](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol) - Work well together: [Ceramide-building complex and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-cholesterol) - Work well together: [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-phytosterol) - Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-squalene) - Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex) - Work well together: [Bio-placenta peptides and phytosphingosine](https://lovi.care/skincare/ie/ingredients/bio-placenta-peptides-and-phytosphingosine) - Work well together: [Collagen peptide and phytosphingosine](https://lovi.care/skincare/ie/ingredients/collagen-peptide-and-phytosphingosine) - Work well together: [Phytosphingosine and copper peptide](https://lovi.care/skincare/ie/ingredients/phytosphingosine-and-copper-peptide) - Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/ie/ingredients/hexapeptide-and-phytosphingosine) - Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/ie/ingredients/phytosphingosine-and-hexapeptide-9) - Work well together: [Phytosphingosine and palmitoyl pentapeptide-4](https://lovi.care/skincare/ie/ingredients/phytosphingosine-and-palmitoyl-pentapeptide-4) - Work well together: [Phytosphingosine and palmitoyl tripeptide-1](https://lovi.care/skincare/ie/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1) - Work well together: [Phytosphingosine and peptide-rich plasma](https://lovi.care/skincare/ie/ingredients/phytosphingosine-and-peptide-rich-plasma) - Work well together: [Phytosphingosine and triple peptide blend](https://lovi.care/skincare/ie/ingredients/phytosphingosine-and-triple-peptide-blend) - Keep them apart: [Salicylic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/salicylic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-baking-soda) - Keep them apart: [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-bleach) - Keep them apart: [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide) - Keep them apart: [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol) - Keep them apart: [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol) - Keep them apart: [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol) - Keep them apart: [Copper and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/copper-and-acetyl-hexapeptide-3) - Keep them apart: [Magnesium and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/magnesium-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-zinc) - Keep them apart: [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3) - Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ie/ingredients/azelaic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-protease) - Keep them apart: [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-phytosphingosine - United Kingdom: https://lovi.care/skincare/uk/ingredients/acetyl-hexapeptide-3-and-phytosphingosine - Ireland: https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-phytosphingosine (this page) - Germany: https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-phytosphingosine - France: https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-phytosphingosine - Italy: https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3-and-phytosphingosine - Netherlands: https://lovi.care/skincare/nl/ingredients/acetyl-hexapeptide-3-and-phytosphingosine - Spain: https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-phytosphingosine - Canada: https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-phytosphingosine - Australia: https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-phytosphingosine - Singapore: https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-phytosphingosine - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-phytosphingosine - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/acetyl-hexapeptide-3-and-phytosphingosine