# SEYOUL vs Sesderma Page: https://lovi.care/skincare/ie/compare/seyoul-vs-sesderma The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland. SEYOUL and Sesderma are distinguished skincare lines known for thoughtful preparations and meticulously engineered formulas. SEYOUL offers nourishing masks with delicate formulas suited best for dry, oily, and combination skin, including the [Collagen](https://lovi.care/skincare/ie/ingredients/collagen) Night Wrapping Mask for acne-prone skin. Meanwhile, the Spanish brand founded in 1989 and owned by Grupo Sesderma since 2026 delivers advanced [serums](https://lovi.care/skincare/ie/ingredients/serum) featuring botanical [extracts](https://lovi.care/skincare/ie/ingredients/extract) and active compounds tailored best for sensitive, hyperpigmented, and aging skin, such as the Azelac RU Serum for acne-prone skin. While both care for the complexion with quiet precision, they differ in their primary product types and specific ingredient synergies. Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026. [skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html) This page compares some of the most popular SEYOUL and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg14bdfc8f10). ### Popular SEYOUL vs Sesderma products #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/ie/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€28.32 at Amazon](https://www.amazon.ie/dp/B00987RKWW?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1) #### SEYOUL - [Collagen Night Wrapping Mask](https://lovi.care/skincare/ie/p/seyoul/collagen-night-wrapping-mask/for/dry-skin) — Average fit ## Questions and answers ### SEYOUL or Sesderma: which is better? Sesderma achieves a High Lovi fit for acne-prone skin and skin with dark spots with its Azelac RU [Serum](https://lovi.care/skincare/ie/ingredients/serum), while SEYOUL products on this page have lower fit levels for those skin concerns. Both brands include items with no fragrance. ### What is the difference between SEYOUL and Sesderma? Sesderma has a High Lovi fit for skin with dark spots, whereas SEYOUL has a Low fit for that skin type. Additionally, the products on this page from SEYOUL list no fragrance, while Sesderma includes fragrance in its Azelac RU Serum. ### Which is more affordable, SEYOUL or Sesderma? This page does not compare the prices or affordability of SEYOUL and Sesderma products. ### Which causes fewer breakouts, SEYOUL or Sesderma? SEYOUL and Sesderma carry different breakout risks depending on your skin type, as SEYOUL carries a caution fit level for acne-prone skin while Sesderma achieves a high fit level for acne-prone skin. ### Which brand has been in business longer, SEYOUL or Sesderma? Sesderma has been in business longer than Sencyoul, having been founded in Spain in 1989 compared to SEYOUL's founding in 2022. ### Do SEYOUL products or Sesderma products contain fragrance? Every product from SEYOUL on this page lists no fragrance in its ingredients, while Sesderma's Azelac RU Serum contains fragrance. ### Where were SEYOUL and Sesderma founded? Sesderma was founded in Spain, whereas the founding location for SEYOUL is not available. ## Research behind their key ingredients - [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000 - [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002 - [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007 - [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004 - [Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics](https://pubmed.ncbi.nlm.nih.gov/35223163/) Collagen · Dermatology Practical & Conceptual, 2022 - [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017 - [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019 - [Use of Collagen in Cosmetic Products](https://pubmed.ncbi.nlm.nih.gov/38534748/) Collagen · Current Issues in Molecular Biology, 2024 - [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021 - [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007 - [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017 - [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024 - [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998 - [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023 - [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025 - [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021 - [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024 ## The brands - Skincare: [SEYOUL](https://lovi.care/skincare/ie/brands/seyoul) - Spanish skincare: [Sesderma](https://lovi.care/skincare/ie/brands/sesderma) ## More comparisons - [SKIN1004 vs SEYOUL](https://lovi.care/skincare/ie/compare/skin1004-vs-seyoul) - [SKIN1004 vs Sesderma](https://lovi.care/skincare/ie/compare/skin1004-vs-sesderma) - [Anua vs SEYOUL](https://lovi.care/skincare/ie/compare/anua-vs-seyoul) - [Anua vs Sesderma](https://lovi.care/skincare/ie/compare/anua-vs-sesderma) - [Medicube vs SEYOUL](https://lovi.care/skincare/ie/compare/medicube-vs-seyoul) - [Medicube vs Sesderma](https://lovi.care/skincare/ie/compare/medicube-vs-sesderma) - [The Ordinary vs SEYOUL](https://lovi.care/skincare/ie/compare/the-ordinary-vs-seyoul) - [The Ordinary vs Sesderma](https://lovi.care/skincare/ie/compare/the-ordinary-vs-sesderma) - [Beauty of Joseon vs SEYOUL](https://lovi.care/skincare/ie/compare/beauty-of-joseon-vs-seyoul) - [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/ie/compare/beauty-of-joseon-vs-sesderma) - [COSRX vs SEYOUL](https://lovi.care/skincare/ie/compare/cosrx-vs-seyoul) - [COSRX vs Sesderma](https://lovi.care/skincare/ie/compare/cosrx-vs-sesderma) - [CeraVe vs SEYOUL](https://lovi.care/skincare/ie/compare/cerave-vs-seyoul) - [CeraVe vs Sesderma](https://lovi.care/skincare/ie/compare/cerave-vs-sesderma) - [La Roche-Posay vs SEYOUL](https://lovi.care/skincare/ie/compare/la-roche-posay-vs-seyoul) - [La Roche-Posay vs Sesderma](https://lovi.care/skincare/ie/compare/la-roche-posay-vs-sesderma) - [Dr. Althea vs SEYOUL](https://lovi.care/skincare/ie/compare/dr-althea-vs-seyoul) - [Dr. Althea vs Sesderma](https://lovi.care/skincare/ie/compare/dr-althea-vs-sesderma) - [Some By Mi vs SEYOUL](https://lovi.care/skincare/ie/compare/some-by-mi-vs-seyoul) - [Some By Mi vs Sesderma](https://lovi.care/skincare/ie/compare/some-by-mi-vs-sesderma) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/compare/seyoul-vs-sesderma - United Kingdom: https://lovi.care/skincare/uk/compare/seyoul-vs-sesderma - Ireland: https://lovi.care/skincare/ie/compare/seyoul-vs-sesderma (this page) - Germany: https://lovi.care/skincare/de/compare/seyoul-vs-sesderma - France: https://lovi.care/skincare/fr/compare/seyoul-vs-sesderma - Italy: https://lovi.care/skincare/it/compare/seyoul-vs-sesderma - Netherlands: https://lovi.care/skincare/nl/compare/seyoul-vs-sesderma - Spain: https://lovi.care/skincare/es/compare/seyoul-vs-sesderma - Canada: https://lovi.care/skincare/ca/compare/seyoul-vs-sesderma - Australia: https://lovi.care/skincare/au/compare/seyoul-vs-sesderma - Singapore: https://lovi.care/skincare/sg/compare/seyoul-vs-sesderma - Saudi Arabia: https://lovi.care/skincare/sa/compare/seyoul-vs-sesderma - United Arab Emirates: https://lovi.care/skincare/ae/compare/seyoul-vs-sesderma