# Paula's Choice vs Clinique

Page: https://lovi.care/skincare/ie/compare/paula-s-choice-vs-clinique

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Paula's Choice and Clinique are American skincare brands known for thoughtful ranges of [serums](https://lovi.care/skincare/ie/ingredients/serum), cleansers, moisturizers, toners, and more. Paula's Choice relies on key ingredients like [hyaluronic acid](https://lovi.care/skincare/ie/ingredients/hyaluronic-acid), [glycerin](https://lovi.care/skincare/ie/ingredients/glycerin), and [vitamin c](https://lovi.care/skincare/ie/ingredients/vitamin-c) to suit oily skin and mature skin best. Conversely, Clinique incorporates hydrating hyaluronic acid, nourishing glycerin, and invigorating [caffeine](https://lovi.care/skincare/ie/ingredients/caffeine) to suit dry sensitive skin and oily skin best. While both brands share a focus on barrier-restoring glycerin, they differ in their founding years, ownership, and targeted product solutions.

Paula's Choice is an American skincare brand founded in 1995 and owned by Unilever since 2021.

[unilever.com](https://www.unilever.com/news/press-and-media/press-releases/2021/unilever-to-acquire-paulas-choice-skincare/) [tracxn.com](https://tracxn.com/d/companies/paulas-choice/__3NzlGcC2yhs-Z9XjkOCar6Dxe0DJgowfl0PAX9OD5s8)

Clinique is an American skincare brand founded in 1968 and owned by The Estée Lauder Companies Inc..

[en.wikipedia.org](https://en.wikipedia.org/wiki/Clinique) [elcompanies.com](https://www.elcompanies.com/en/who-we-are/our-heritage) [businesswire.com](https://www.businesswire.com/news/home/20261019083802/en/The-Este-Lauder-Companies-Appoints-Krista-Lee-Berger-Senior-Vice-President-Global-Marketing-Clinique) [glossy.co](https://www.glossy.co/beauty/glossy-pop-newsletter-clinique-launches-first-ever-creator-led-campaign/)

This page compares some of the most popular Paula's Choice and Clinique products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg8a70b82d67).

### Popular Paula's Choice vs Clinique products

#### Paula's Choice

- [Skin Perfecting 2% BHA Liquid Exfoliant](https://lovi.care/skincare/ie/p/paula-s-choice/skin-perfecting-2-bha-liquid-exfoliant/for/oily-skin) — Superior fit — [€39.00 at Amazon](https://www.amazon.ie/dp/B07R53ZLMV?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [1% Retinol Treatment](https://lovi.care/skincare/ie/p/paula-s-choice/1-retinol-treatment/for/dark-spots) — Superior fit
- [10% Azelaic Acid Booster](https://lovi.care/skincare/ie/p/paula-s-choice/10-azelaic-acid-booster/for/acne-prone-skin) — High fit — [€16.04 at Amazon](https://www.amazon.ie/dp/B0DJVSVL56?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [C15 Super Booster](https://lovi.care/skincare/ie/p/paula-s-choice/c15-super-booster/for/mature-skin) — High fit
- [CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/ie/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — [€32.00 at Amazon](https://www.amazon.ie/dp/B07TJRPXCZ?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [10% Niacinamide Booster](https://lovi.care/skincare/ie/p/paula-s-choice/10-niacinamide-booster/for/dry-sensitive-skin) — Superior fit — [€59.00 at Amazon](https://www.amazon.ie/dp/B07QCWTYJ2?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Weightless Body Treatment 2% BHA](https://lovi.care/skincare/ie/p/paula-s-choice/weightless-body-treatment-2-bha/for/oily-acne-prone-skin) — Average fit
- [Skin Balancing Pore-Reducing Toner](https://lovi.care/skincare/ie/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — [€36.00 at Amazon](https://www.amazon.ie/dp/B07P7VZ2J9?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)

#### Clinique

- [moisture surge](https://lovi.care/skincare/ie/p/clinique/moisture-surge/for/sensitive-skin) — High fit
- [Take The Day Off Cleansing Balm](https://lovi.care/skincare/ie/p/clinique/take-the-day-off-cleansing-balm/for/dry-skin) — Average fit — [€19.40 at Amazon](https://www.amazon.ie/dp/B07F1LRBCF?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Dramatically Different Moisturizing Lotion+](https://lovi.care/skincare/ie/p/clinique/dramatically-different-moisturizing-lotion/for/dry-skin) — Average fit — [€5.70 at Notino](https://www.notino.ie/clinique/3-steps-dramatically-different-moisturizing-lotion-for-very-dry-to-dry-combination-skin/p-67230/)
- [All About Eyes](https://lovi.care/skincare/ie/p/clinique/all-about-eyes/for/dry-skin) — High fit — [€58.00 at Amazon](https://www.amazon.ie/dp/B002SPYL7S?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Dramatically Different Moisturizing Gel](https://lovi.care/skincare/ie/p/clinique/dramatically-different-moisturizing-gel/for/oily-skin) — High fit — [€17.50 at Notino](https://www.notino.ie/clinique/3-steps-dramatically-different-moisturizing-gel-for-combination-oily-to-oily-skin/p-68905/)
- [Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/ie/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit
- [Moisture Surge Overnight Mask](https://lovi.care/skincare/ie/p/clinique/moisture-surge-overnight-mask/for/dry-skin) — High fit — [€52.58 at Amazon](https://www.amazon.ie/dp/B0FGG612LR?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Clarifying Lotion 2](https://lovi.care/skincare/ie/p/clinique/clarifying-lotion-2/for/oily-acne-prone-skin) — Average fit — [€27.25 at Amazon](https://www.amazon.ie/dp/B01FBWEORQ?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)

## People Say

Paula's Choice

Clinique

- Lightweight and fast absorbing Mostly Mentioned Mostly Mentioned “Provides an internal level of hydration without leaving any heavy finish. — Paula's Choice Skin Balancing Pore-Reducing Toner” “Absorbs quickly and leaves no greasy residue behind. — Paula's Choice Clear Oil-Free Moisturizer” “absorbs instantly — Paula's Choice C15 Super Booster” “sinks in immediately — Clinique moisture surge”
- Gentle and non-irritating Often Mentioned Mostly Mentioned “never irritated my eyes — Clinique All About Eyes” “No stinging eyes — Clinique Take The Day Off Cleansing Balm” “cools the heat in my cheeks — Clinique Redness Solutions Daily Relief Cream” “Finally a vitamin C product I can use — Paula's Choice 25% Vitamin C + Glutathione Clinical Serum”
- Smoothes texture and refines pores Mostly Mentioned Rarely Noted “skin becomes very smooth — Paula's Choice 1% Retinol Treatment” “pores look smaller — Paula's Choice 10% Niacinamide Booster” “bumps be gone — Paula's Choice Weightless Body Treatment 2% BHA” “leaves face porcelain smooth — Clinique 7 Day Scrub Cream Rinse-Off Formula”
- Glow and radiance Often Mentioned Rarely Noted “visible glow — Paula's Choice C15 Super Booster” “softens lines and wrinkles — Paula's Choice 1% Retinol Treatment” “acne scars faded — Paula's Choice 10% Azelaic Acid Booster” “wake up glowing — Clinique Moisture Surge Overnight Mask”
- Unclogs pores and clears acne Often Mentioned Not noted “cleared my bumps — Paula's Choice Skin Perfecting 2% BHA Liquid Exfoliant” “Helped clear my cystic acne — Paula's Choice CLEAR Pore Normalizing Cleanser” “heals blemishes faster — Paula's Choice Skin Perfecting 2% BHA Liquid Exfoliant”
- Firms and plumps Sometimes Noted Sometimes Noted “skin looks plumper — Paula's Choice Pro-Collagen Multi-Peptide Booster” “improved neck texture — Paula's Choice Skin-Smoothing Retinol Body Treatment” “glass skin look — Clinique moisture surge” “visibly plumped up — Clinique Smart Clinical Repair Wrinkle Correcting Serum”
- High price and small size Mostly Mentioned Often Mentioned “surprisingly small bottle — Paula's Choice Skin-Smoothing Retinol Body Treatment” “tiny tube — Paula's Choice 10% Azelaic Acid Booster” “jar is too small for the cost — Clinique moisture surge” “quite pricey — Clinique Smart Clinical Repair Wrinkle Correcting Serum”
- Causes purging or breakouts Often Mentioned Sometimes Noted “peeling and flaking — Paula's Choice 1% Retinol Treatment” “skin purged — Paula's Choice Skin Perfecting 2% BHA Liquid Exfoliant” “Woke up with whiteheads on my chin — Clinique Dramatically Different Moisturizing Lotion+” “gave me tiny bumps — Clinique moisture surge”
- Unpleasant smell or scent Often Mentioned Sometimes Noted “Smells like nail polish remover — Clinique Clarifying Lotion 2” “Smells like old oil — Clinique Take The Day Off Cleansing Balm” “Has a weird plastic-like smell — Clinique Dramatically Different Moisturizing Lotion+” “smells like grain — Paula's Choice 10% Azelaic Acid Booster”
- Drying and flaking Sometimes Noted Often Mentioned “Not hydrating enough for winter. — Paula's Choice Clear Oil-Free Moisturizer” “dryness and scaliness — Paula's Choice Skin Perfecting 2% BHA Liquid Exfoliant” “Made my skin flaky — Paula's Choice CLEAR Pore Normalizing Cleanser” “skin felt tight — Clinique Dramatically Different Moisturizing Gel”

### Paula's Choice vs Clinique routines for dry skin

#### Paula's Choice-focused routine

- Cleanser: [CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/ie/p/paula-s-choice/clear-pore-normalizing-cleanser/for/dry-skin) — Caution fit — [€32.00 at Amazon](https://www.amazon.ie/dp/B07TJRPXCZ?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Skin Recovery Enriched Calming Toner](https://lovi.care/skincare/ie/p/paula-s-choice/skin-recovery-enriched-calming-toner/for/dry-skin) — Superior fit — [€36.00 at Amazon](https://www.amazon.ie/dp/B07TSNW8Y2?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning
- Moisturizer: [Replenishing Moisturizer](https://lovi.care/skincare/ie/p/paula-s-choice/replenishing-moisturizer/for/dry-skin) — High fit — [€45.00 at Amazon](https://www.amazon.ie/dp/B07SC3MMQ8?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [thinkbaby Safe Sunscreen SPF 50+](https://lovi.care/skincare/ie/p/thinkbaby/safe-sunscreen-spf-50/for/dry-skin) — Superior fit — [€32.81 at Amazon](https://www.amazon.ie/dp/B00JJZN1HG?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/ie/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — [€16.25 at Amazon](https://www.amazon.ie/dp/B084Q16G8D?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Serum or Treatment: [10% Niacinamide Booster](https://lovi.care/skincare/ie/p/paula-s-choice/10-niacinamide-booster/for/dry-skin) — High fit — [€59.00 at Amazon](https://www.amazon.ie/dp/B07QCWTYJ2?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Nourishing Mask: [Mediheal Watermide Essential Mask](https://lovi.care/skincare/ie/p/mediheal/watermide-essential-mask/for/dry-skin) — Superior fit — [€28.40 at Amazon](https://www.amazon.ie/dp/B00JE7TEES?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Once a week

#### Clinique-focused routine

- Cleanser: [all about clean](https://lovi.care/skincare/ie/p/clinique/all-about-clean/for/dry-skin) — Warning fit — [€30.00 at Amazon](https://www.amazon.ie/dp/B00BNAQDVG?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ie/p/cosrx/propolis-synergy-toner/for/dry-skin) — Superior fit — [€14.28 at Amazon](https://www.amazon.ie/dp/B089SCWPJR?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning
- Moisturizer: [Smart Clinical Repair Lifting Face + Neck Cream](https://lovi.care/skincare/ie/p/clinique/smart-clinical-repair-lifting-face-neck-cream/for/dry-skin) — High fit — [€78.09 at Amazon](https://www.amazon.ie/dp/B0CHXGY211?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [thinkbaby Safe Sunscreen SPF 50+](https://lovi.care/skincare/ie/p/thinkbaby/safe-sunscreen-spf-50/for/dry-skin) — Superior fit — [€32.81 at Amazon](https://www.amazon.ie/dp/B00JJZN1HG?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Take The Day Off Cleansing Balm](https://lovi.care/skincare/ie/p/clinique/take-the-day-off-cleansing-balm/for/dry-skin) — Average fit — [€19.40 at Amazon](https://www.amazon.ie/dp/B07F1LRBCF?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Serum or Treatment: [Even Better Clinical Dark Spot Corrector](https://lovi.care/skincare/ie/p/clinique/even-better-clinical-dark-spot-corrector/for/dry-skin) — Average fit — Evening · Once a week
- Nourishing Mask: [Moisture Surge Overnight Mask](https://lovi.care/skincare/ie/p/clinique/moisture-surge-overnight-mask/for/dry-skin) — High fit — [€52.58 at Amazon](https://www.amazon.ie/dp/B0FGG612LR?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Once a week

[See multi-brand routine · 98% fit](https://lovi.care/skincare/ie/skin/dry-skin)

### Paula's Choice vs Clinique routines for oily skin

#### Paula's Choice-focused routine

- Cleanser: [CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/ie/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-skin) — Superior fit — [€32.00 at Amazon](https://www.amazon.ie/dp/B07TJRPXCZ?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Advanced Replenishing Toner](https://lovi.care/skincare/ie/p/paula-s-choice/advanced-replenishing-toner/for/oily-skin) — High fit — [€36.00 at Amazon](https://www.amazon.ie/dp/B07TSNW8Y2?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Clear Oil-Free Moisturizer](https://lovi.care/skincare/ie/p/paula-s-choice/clear-oil-free-moisturizer/for/oily-skin) — High fit — [€48.00 at Amazon](https://www.amazon.ie/dp/B07P5SPQ31?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [CeraVe AM Facial Moisturizing Lotion SPF 30](https://lovi.care/skincare/ie/p/cerave/am-facial-moisturizing-lotion-spf-30/for/oily-skin) — Superior fit — [€15.64 at Amazon](https://www.amazon.ie/dp/B0BT6VDJ5M?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Pyunkang Yul Deep Cleansing Oil](https://lovi.care/skincare/ie/p/pyunkang-yul/deep-cleansing-oil/for/oily-skin) — Superior fit — [€22.67 at Amazon](https://www.amazon.ie/dp/B08QTT1QBX?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Pixi Glow Tonic](https://lovi.care/skincare/ie/p/pixi/glow-tonic/for/oily-skin) — Superior fit — [€34.00 at Amazon](https://www.amazon.ie/dp/B07RWL29GF?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Niacinamide 20% Treatment](https://lovi.care/skincare/ie/p/paula-s-choice/niacinamide-20-treatment/for/oily-skin) — Superior fit — [€63.00 at Amazon](https://www.amazon.ie/dp/B08SW6VPJL?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/ie/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [€76.00 at Amazon](https://www.amazon.ie/dp/B071ZBJPH7?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Dr. Sebagh Deep Exfoliating Mask](https://lovi.care/skincare/ie/p/dr-sebagh/deep-exfoliating-mask/for/oily-skin) — Superior fit — [€82.85 at Amazon](https://www.amazon.ie/dp/B003E71NPC?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Once a week

#### Clinique-focused routine

- Cleanser: [Redness Solutions Soothing Cleanser](https://lovi.care/skincare/ie/p/clinique/redness-solutions-soothing-cleanser/for/oily-skin) — Average fit — [€31.05 at Lookfantastic](https://www.lookfantastic.ie/p/clinique-clinique-redness-solutionssoothing-cleanser-for-unisex-0/11144770/) — Morning · Evening · Once a week
- Hydrating Toner: [Some By Mi Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/ie/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — [€19.99 at Amazon](https://www.amazon.ie/dp/B08125WDCF?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Dramatically Different Moisturizing Gel](https://lovi.care/skincare/ie/p/clinique/dramatically-different-moisturizing-gel/for/oily-skin) — High fit — [€17.50 at Notino](https://www.notino.ie/clinique/3-steps-dramatically-different-moisturizing-gel-for-combination-oily-to-oily-skin/p-68905/) — Morning · Evening · Once a week
- SPF: [CeraVe AM Facial Moisturizing Lotion SPF 30](https://lovi.care/skincare/ie/p/cerave/am-facial-moisturizing-lotion-spf-30/for/oily-skin) — Superior fit — [€15.64 at Amazon](https://www.amazon.ie/dp/B0BT6VDJ5M?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Take The Day Off Cleansing Balm](https://lovi.care/skincare/ie/p/clinique/take-the-day-off-cleansing-balm/for/oily-skin) — Low fit — [€19.40 at Amazon](https://www.amazon.ie/dp/B07F1LRBCF?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Clarifying Lotion 2](https://lovi.care/skincare/ie/p/clinique/clarifying-lotion-2/for/oily-skin) — Average fit — [€27.25 at Amazon](https://www.amazon.ie/dp/B01FBWEORQ?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Even Better Clinical Dark Spot Corrector](https://lovi.care/skincare/ie/p/clinique/even-better-clinical-dark-spot-corrector/for/oily-skin) — High fit — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/ie/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [€76.00 at Amazon](https://www.amazon.ie/dp/B071ZBJPH7?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Dr. Sebagh Deep Exfoliating Mask](https://lovi.care/skincare/ie/p/dr-sebagh/deep-exfoliating-mask/for/oily-skin) — Superior fit — [€82.85 at Amazon](https://www.amazon.ie/dp/B003E71NPC?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Once a week

[See multi-brand routine · 96% fit](https://lovi.care/skincare/ie/skin/oily-skin)

### Paula's Choice vs Clinique routines for combination skin

#### Paula's Choice-focused routine

- Cleanser: [CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/ie/p/paula-s-choice/clear-pore-normalizing-cleanser/for/combination-skin) — Superior fit — [€32.00 at Amazon](https://www.amazon.ie/dp/B07TJRPXCZ?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Advanced Replenishing Toner](https://lovi.care/skincare/ie/p/paula-s-choice/advanced-replenishing-toner/for/combination-skin) — High fit — [€36.00 at Amazon](https://www.amazon.ie/dp/B07TSNW8Y2?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Clear Oil-Free Moisturizer](https://lovi.care/skincare/ie/p/paula-s-choice/clear-oil-free-moisturizer/for/combination-skin) — Average fit — [€48.00 at Amazon](https://www.amazon.ie/dp/B07P5SPQ31?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Pre-Cleanser: [Pyunkang Yul Deep Cleansing Oil](https://lovi.care/skincare/ie/p/pyunkang-yul/deep-cleansing-oil/for/combination-skin) — Superior fit — [€22.67 at Amazon](https://www.amazon.ie/dp/B08QTT1QBX?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Medicube Zero Pore Pad 2.0](https://lovi.care/skincare/ie/p/medicube/zero-pore-pad-2-0/for/combination-skin) — Superior fit — [€22.99 at Amazon](https://www.amazon.ie/dp/B0FNRTX91F?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Niacinamide 20% Treatment](https://lovi.care/skincare/ie/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin) — Superior fit — [€63.00 at Amazon](https://www.amazon.ie/dp/B08SW6VPJL?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/ie/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [€76.00 at Amazon](https://www.amazon.ie/dp/B071ZBJPH7?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Sand & Sky Australian Pink Clay Porefining Face Mask](https://lovi.care/skincare/ie/p/sand-and-sky/australian-pink-clay-porefining-face-mask/for/combination-skin) — High fit — [€48.22 at Amazon](https://www.amazon.ie/dp/B076Z6PVVQ?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Once a week

#### Clinique-focused routine

- Cleanser: [all about clean](https://lovi.care/skincare/ie/p/clinique/all-about-clean/for/combination-skin) — Low fit — [€30.00 at Amazon](https://www.amazon.ie/dp/B00BNAQDVG?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/ie/p/la-mer/the-tonic/for/combination-skin) — Superior fit — [€115.30 at Amazon](https://www.amazon.ie/dp/B0CY5LW9DY?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Dramatically Different Moisturizing Gel](https://lovi.care/skincare/ie/p/clinique/dramatically-different-moisturizing-gel/for/combination-skin) — Average fit — [€17.50 at Notino](https://www.notino.ie/clinique/3-steps-dramatically-different-moisturizing-gel-for-combination-oily-to-oily-skin/p-68905/) — Morning · Evening · Once a week
- Pre-Cleanser: [Take The Day Off Cleansing Balm](https://lovi.care/skincare/ie/p/clinique/take-the-day-off-cleansing-balm/for/combination-skin) — Low fit — [€19.40 at Amazon](https://www.amazon.ie/dp/B07F1LRBCF?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Clarifying Lotion 2](https://lovi.care/skincare/ie/p/clinique/clarifying-lotion-2/for/combination-skin) — Average fit — [€27.25 at Amazon](https://www.amazon.ie/dp/B01FBWEORQ?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Even Better Clinical Dark Spot Corrector](https://lovi.care/skincare/ie/p/clinique/even-better-clinical-dark-spot-corrector/for/combination-skin) — Average fit — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/ie/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [€76.00 at Amazon](https://www.amazon.ie/dp/B071ZBJPH7?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Sand & Sky Australian Pink Clay Porefining Face Mask](https://lovi.care/skincare/ie/p/sand-and-sky/australian-pink-clay-porefining-face-mask/for/combination-skin) — High fit — [€48.22 at Amazon](https://www.amazon.ie/dp/B076Z6PVVQ?tag=lovi-care-web-routine08-21&linkCode=osi&th=1&psc=1) — Once a week

[See multi-brand routine · 95% fit](https://lovi.care/skincare/ie/skin/combination-skin)

## Questions and answers

### Paula's Choice or Clinique: which is better?

Paula's Choice is better for oily, acne-prone, and mature skin types, whereas both brands offer a High routine fit for dry and sensitive skin. Reviewers note that Paula's Choice is superior for smoothing texture, refining pores, and clearing acne.

### What is the difference between Paula's Choice and Clinique?

Paula's Choice achieves a Superior Lovi routine fit for oily, oily acne-prone, acne-prone, and mature skin, whereas Clinique achieves a High fit for those types. Paula's Choice relies heavily on exfoliants like [salicylic acid](https://lovi.care/skincare/ie/ingredients/salicylic-acid), while Clinique focuses more on hydrating moisturizers and makeup removers.

### Paula's Choice or Clinique for dry skin?

Both Paula's Choice and Clinique fit dry skin well, offering a High routine fit on the products on this page. Paula's Choice helps with targeted exfoliation and hydrating toners, while Clinique is known for its gentle cleansers and soothing moisturizers.

### Paula's Choice or Clinique: which cleanser is better?

Paula's Choice cleansers generally achieve a Superior fit for oily and acne-prone skin, whereas Clinique cleansers vary widely with several ratings in the lower or warning tiers for those skin types.

### Which is more affordable, Paula's Choice or Clinique?

Both Paula's Choice and Clinique face negative feedback regarding their high price points from reviewers on this page.

### Which brand has a better routine fit for oily acne-prone skin?

Paula's Choice has a superior routine fit for oily acne-prone skin, whereas Clinique has a high routine fit for this skin type.

### Paula's Choice or Clinique: which is better for skin with dark spots?

Paula's Choice is better for skin with dark spots, offering a High routine fit compared to Clinique's Average level. [Niacinamide](https://lovi.care/skincare/ie/ingredients/niacinamide) helps reduce cutaneous pigmentation and suppresses melanosome transfer.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Paula's Choice or Clinique for oily skin?

Paula's Choice is a better fit for oily skin, offering a Superior routine compared to Clinique's High fit level. The products on this page help control oil and refine pores effectively.

### Paula's Choice or Clinique: which moisturizer is better?

Paula's Choice moisturizers are generally better suited for oily and acne-prone skin types, whereas Clinique moisturizers excel in providing lightweight, hydrating, and gentle care across various skin types.

### Paula's Choice or Clinique for sensitive skin?

Both Paula's Choice and Clinique are well-suited for sensitive skin, with Lovi giving both brands a High fit level. Reviewers note that Clinique is particularly gentle and non-irritating.

### Paula's Choice or Clinique for acne-prone skin?

Paula's Choice is better suited for acne-prone skin, achieving a Superior routine fit compared to Clinique's Average fit on this page. Paula's Choice features fragrance-free products that help unclog pores and clear acne.

### Paula's Choice or Clinique for mature skin?

Paula's Choice is a superior fit for mature skin, whereas Clinique achieves a high fit level. Paula's choice products on this page help smooth texture and provide anti-aging [serums](https://lovi.care/skincare/ie/ingredients/serum).

[The Journal of Investigative Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/10692106/)

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology](https://pubmed.ncbi.nlm.nih.gov/19169201/) Squalene · Molecules, 2009
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Sodium hyaluronate · Drug Delivery, 2017
- [Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress](https://pubmed.ncbi.nlm.nih.gov/11181450/) Epigallocatechin gallate · Carcinogenesis, 2001
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments](https://pubmed.ncbi.nlm.nih.gov/21952107/) Rice bran oil · Journal of Nanobiotechnology, 2011
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Hyaluronic acid, Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol, Panthenol vitamin b5 · American Journal of Clinical Dermatology, 2002
- [Caffeine's mechanisms of action and its cosmetic use](https://pubmed.ncbi.nlm.nih.gov/23075568/) Caffeine · Skin Pharmacology and Physiology, 2013
- [Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes](https://pubmed.ncbi.nlm.nih.gov/23096708/) Epigallocatechin gallate · The Journal of Investigative Dermatology, 2013
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin](https://pubmed.ncbi.nlm.nih.gov/28330776/) Micro-acid complex · Journal of Dermatological Science, 2017
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol · Journal of Cosmetic Dermatology, 2020
- [A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation](https://pubmed.ncbi.nlm.nih.gov/18603326/) Ferulic acid · Journal of the American Academy of Dermatology, 2008
- [Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin](https://pubmed.ncbi.nlm.nih.gov/19146606/) Ferulic acid · Journal of Cosmetic Dermatology, 2008
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Protecting skin photoaging by NF-kappaB inhibitor](https://pubmed.ncbi.nlm.nih.gov/20540695/) Magnolia officinalis bark extract · Current Drug Metabolism, 2010
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol, Bakuchiol · The British Journal of Dermatology, 2019
- [Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo](https://pubmed.ncbi.nlm.nih.gov/19186973/) Ascorbyl glucoside · Journal of Periodontology, 2009
- [Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women](https://pubmed.ncbi.nlm.nih.gov/25378941/) Glutathione · Clinical, Cosmetic and Investigational Dermatology, 2014
- [Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo](https://pubmed.ncbi.nlm.nih.gov/27279007/) Chamomilla recutita flower extract matricaria flower extract · International Journal of Molecular Medicine, 2016
- [Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects](https://pubmed.ncbi.nlm.nih.gov/26648450/) Ubiquinone · BioFactors, 2015
- [Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin](https://pubmed.ncbi.nlm.nih.gov/33037252/) Squalane · Scientific Reports, 2020
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf water, Aloe barbadensis · Clinical Pharmacology, 2018
- [Urea: a comprehensive review of the clinical literature](https://pubmed.ncbi.nlm.nih.gov/24314769/) Urea · Dermatology Online Journal, 2013
- [A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topical Application of Epigallocatechin-3-Gallate in the Modulation of Cutaneous Scarring in Human Skin](https://pubmed.ncbi.nlm.nih.gov/30822414/) Epigallocatechin gallate · The Journal of Investigative Dermatology, 2019
- [Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin](https://pubmed.ncbi.nlm.nih.gov/35340018/) Ceramides · Scientific Reports, 2022
- [Topical benzoyl peroxide for acne](https://pubmed.ncbi.nlm.nih.gov/32175593/) Benzoyl peroxide · The Cochrane Database of Systematic Reviews, 2020
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ferulic acid, Tocopherol, Ascorbic acid, Tocopherol vitamin e · Journal of Cosmetic Dermatology, 2020
- [Licochalcone A activates Nrf2 in vitro and contributes to licorice extract-induced lowered cutaneous oxidative stress in vivo](https://pubmed.ncbi.nlm.nih.gov/25381913/) Licorice root extract, Glycyrrhiza glabra root extract licorice root extract · Experimental Dermatology, 2015
- [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Retinyl palmitate · International Journal of Nanomedicine, 2021
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [Effect of 30% Supramolecular Salicylic Acid Peel on Skin Microbiota and Inflammation in Patients with Moderate-to-Severe Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/36350527/) Micro-acid complex · Dermatology and Therapy, 2023
- [Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy](https://pubmed.ncbi.nlm.nih.gov/36985709/) Polygonum cuspidatum root extract · Molecules, 2023
- [Role of Resveratrol in Regulating Cutaneous Functions](https://pubmed.ncbi.nlm.nih.gov/32382280/) Polygonum cuspidatum root extract · Evidence-based Complementary and Alternative Medicine, 2020
- [The clinical effect of glutathione on skin color and other related skin conditions: A systematic review](https://pubmed.ncbi.nlm.nih.gov/30895708/) Glutathione · Journal of Cosmetic Dermatology, 2019
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Benzoyl peroxide treatment decreases Cutibacterium acnes in shoulder surgery, from skin incision until wound closure](https://pubmed.ncbi.nlm.nih.gov/33545336/) Benzoyl peroxide · Journal of Shoulder and Elbow Surgery, 2021
- [Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial](https://pubmed.ncbi.nlm.nih.gov/19845667/) Acetyl glucosamine · The British Journal of Dermatology, 2010
- [Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine](https://pubmed.ncbi.nlm.nih.gov/17348991/) Acetyl glucosamine · Journal of Cosmetic Dermatology, 2007
- [Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug](https://pubmed.ncbi.nlm.nih.gov/34674160/) Benzoyl peroxide · American Journal of Clinical Dermatology, 2022
- [A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen](https://pubmed.ncbi.nlm.nih.gov/20374604/) Retinyl propionate · The British Journal of Dermatology, 2010
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol, Panthenol vitamin b5 · The Journal of Dermatological Treatment, 2017
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate · Urologia Internationalis, 2019
- [Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB](https://pubmed.ncbi.nlm.nih.gov/17346696/) Magnolia officinalis bark extract · European Journal of Pharmacology, 2007
- [Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration](https://pubmed.ncbi.nlm.nih.gov/29574973/) Adenosine · International Journal of Cosmetic Science, 2018
- [Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/31553119/) Mandelic acid · Journal of Cosmetic Dermatology, 2020
- [Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days](https://pubmed.ncbi.nlm.nih.gov/30924254/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2019
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin, Panthenol · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Tetrahexyldecyl ascorbate · Photochemistry and Photobiology, 2021
- [Topical glutathione amino acid precursors protect skin against environmental and oxidative stress](https://pubmed.ncbi.nlm.nih.gov/38189670/) Glutathione · Journal of the European Academy of Dermatology and Venereology, 2024
- [An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects](https://pubmed.ncbi.nlm.nih.gov/32099438/) Blueberry fruit extract · Clinical, Cosmetic and Investigational Dermatology, 2020
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin](https://pubmed.ncbi.nlm.nih.gov/11684194/) Witch hazel extract · Phytochemistry, 2001
- [In vivo skin irritation potential of a Castanea sativa (Chestnut) leaf extract, a putative natural antioxidant for topical application](https://pubmed.ncbi.nlm.nih.gov/18793273/) Chestnut leaf extract · Basic & Clinical Pharmacology & Toxicology, 2008
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Efficacy of Probiotic Supplements and Topical Applications in the Treatment of Acne: A Scoping Review of Current Results](https://pubmed.ncbi.nlm.nih.gov/39810881/) Probiotic technology · Journal of Experimental Pharmacology, 2025
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid, Micro-acid complex · Journal of Cosmetic Dermatology, 2024
- [Clinical evaluation of photoprotective effect by a topical antioxidants combination (tocopherols and tocotrienols)](https://pubmed.ncbi.nlm.nih.gov/21917024/) Tocotrienols · Journal of the European Academy of Dermatology and Venereology, 2012
- [Tocotrienol-rich fraction attenuates UV-induced inflammaging: A bench to bedside study](https://pubmed.ncbi.nlm.nih.gov/28952200/) Tocotrienols · Journal of Cosmetic Dermatology, 2018
- [Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects](https://pubmed.ncbi.nlm.nih.gov/32129554/) Vitamin e · Journal of Cosmetic Dermatology, 2020
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment](https://pubmed.ncbi.nlm.nih.gov/19134126/) Sodium ascorbyl phosphate · International Journal of Cosmetic Science, 2009
- [Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol](https://pubmed.ncbi.nlm.nih.gov/27391637/) Hexylresorcinol · Journal of Drugs in Dermatology, 2016
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study](https://pubmed.ncbi.nlm.nih.gov/22585103/) Jojoba seed oil · Forschende Komplementarmedizin, 2012
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques](https://pubmed.ncbi.nlm.nih.gov/28385617/) Tetrahexyldecyl ascorbate · European Journal of Pharmaceutics and Biopharmaceutics, 2017
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Efficacy and safety of microencapsulated benzoyl peroxide and microencapsulated tretinoin for the treatment of acne vulgaris: Results from two phase 3 double-blind, randomized, vehicle-controlled studies](https://pubmed.ncbi.nlm.nih.gov/37356627/) Benzoyl peroxide · Journal of the American Academy of Dermatology, 2023
- [A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial](https://pubmed.ncbi.nlm.nih.gov/25914553/) Bakuchiol · Clinical, Cosmetic and Investigational Dermatology, 2015
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide](https://pubmed.ncbi.nlm.nih.gov/34958693/) Hexylresorcinol · International Journal of Cosmetic Science, 2022
- [Chemical peels for acne vulgaris: a systematic review of randomised controlled trials](https://pubmed.ncbi.nlm.nih.gov/29705755/) Mandelic acid · BMJ Open, 2018
- [Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations](https://pubmed.ncbi.nlm.nih.gov/35274433/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Stretchable skin hydrating PVB patches with controlled pores' size and shape for deliberate evening primrose oil spreading, transport and release](https://pubmed.ncbi.nlm.nih.gov/35929319/) Oenothera biennis oil · Biomaterials Advances, 2022
- [Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)](https://pubmed.ncbi.nlm.nih.gov/11278060/) Sodium laureth sulfate · Food and Chemical Toxicology, 2001
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study](https://pubmed.ncbi.nlm.nih.gov/36729399/) Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023
- [Whitening effect of alpha-bisabolol in Asian women subjects](https://pubmed.ncbi.nlm.nih.gov/20642768/) Bisabolol · International Journal of Cosmetic Science, 2010
- [Is benzyl alcohol a significant contact sensitizer?](https://pubmed.ncbi.nlm.nih.gov/35080274/) Benzyl alcohol · Journal of the European Academy of Dermatology and Venereology, 2022
- [Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane](https://pubmed.ncbi.nlm.nih.gov/22247236/) Cyclopentasiloxane · International Journal of Toxicology, 2011
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [Inhibitory effects of shell of Camellia oleifera Abel extract on mushroom tyrosinase and human skin melanin](https://pubmed.ncbi.nlm.nih.gov/31033161/) Butylene glycol · Journal of Cosmetic Dermatology, 2019
- [Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison](https://pubmed.ncbi.nlm.nih.gov/30022595/) Willow bark extract · Journal of Cosmetic Dermatology, 2019
- [Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract](https://pubmed.ncbi.nlm.nih.gov/30690691/) Willow bark extract · Planta Medica, 2019
- [Apple Extract (Malus sp.) and Rutin as Photochemopreventive Agents: Evaluation of Ultraviolet B-Induced Alterations on Skin Biopsies and Tissue-Engineered Skin](https://pubmed.ncbi.nlm.nih.gov/32242497/) Pyrus malus fruit extract · Rejuvenation Research, 2020
- [Administration of skin care regimens containing β-glucan for skin recovery after fractional laser therapy: A split-face, double-blinded, vehicle-controlled study](https://pubmed.ncbi.nlm.nih.gov/33128496/) Beta-glucan · Journal of Cosmetic Dermatology, 2021
- [Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers](https://pubmed.ncbi.nlm.nih.gov/27756097/) Sodium ascorbyl phosphate · Drug Research, 2017
- [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023
- [Understanding Solar Skin Elastosis-Cause and Treatment](https://pubmed.ncbi.nlm.nih.gov/30052192/) Witch hazel extract · Journal of Cosmetic Science, 2018
- [Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement](https://pubmed.ncbi.nlm.nih.gov/30160014/) Adenosine · Journal of Cosmetic Dermatology, 2019
- [The impacts of sodium lauroyl sarcosinate in facial cleanser on facial skin microbiome and lipidome](https://pubmed.ncbi.nlm.nih.gov/37990616/) Sodium lauroyl sarcosinate · Journal of Cosmetic Dermatology, 2024
- [Nanostructured Lipid Carrier for Topical Application of N-Acetyl Glucosamine](https://pubmed.ncbi.nlm.nih.gov/28101465/) Acetyl glucosamine · Advanced Pharmaceutical Bulletin, 2016
- [Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids](https://pubmed.ncbi.nlm.nih.gov/12482041/) Phytosphingosine · Journal of the European Academy of Dermatology and Venereology, 2002
- [Stability, antioxidant activity, in vivo safety and efficacy of creams with standardized wild apple fruit extract: a comparison of conventional and biodegradable emulsifiers](https://pubmed.ncbi.nlm.nih.gov/31050807/) Pyrus malus fruit extract · International Journal of Cosmetic Science, 2019
- [Borage Oil Treated with Immobilized Lipase Inhibits Melanogenesis](https://pubmed.ncbi.nlm.nih.gov/33128473/) Borago officinalis oil, Borago officinalis seed oil · Lipids, 2020
- [Development, Characterization, and Clinical Investigation of a New Topical Emulsion System Containing a Castanea sativa Spiny Burs Active Extract](https://pubmed.ncbi.nlm.nih.gov/34683927/) Chestnut leaf extract · Pharmaceutics, 2021
- [Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast](https://pubmed.ncbi.nlm.nih.gov/40363772/) Squalane · Molecules, 2025
- [Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects](https://pubmed.ncbi.nlm.nih.gov/39383579/) Palmitoyl tripeptide-5 · Colloids and Surfaces. B, Biointerfaces, 2025
- [Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis](https://pubmed.ncbi.nlm.nih.gov/37763018/) Yeast extract · Journal of Clinical Medicine, 2023
- [Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota](https://pubmed.ncbi.nlm.nih.gov/39598779/) Camellia sinensis leaf extract · Molecules, 2024
- [Novel beads made of alpha-cyclodextrin and oil for topical delivery of a lipophilic drug](https://pubmed.ncbi.nlm.nih.gov/17671830/) Glycine soja oil soybean oil · Pharmaceutical Research, 2008
- [Randomized prospective study of low-dose isotretinoin alone and combination with salicylic acid and mandelic peel against acne tarda](https://pubmed.ncbi.nlm.nih.gov/35388606/) Mandelic acid · Journal of Cosmetic Dermatology, 2022
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles](https://pubmed.ncbi.nlm.nih.gov/32783330/) Dimethoxytolyl propylresorcinol · Journal of Cosmetic Dermatology, 2021
- [Synergistic action of a triple peptide complex on an essential extra-cellular matrix protein exhibits significant anti-aging benefits](https://pubmed.ncbi.nlm.nih.gov/20618556/) Multi-peptides · Journal of Cosmetic Dermatology, 2010
- [Algae extract protection effect on oxidized protein level in human stratum corneum](https://pubmed.ncbi.nlm.nih.gov/15247018/) Algae extract · Annals of the New York Academy of Sciences, 2004
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol, Panthenol vitamin b5 · Journal of Cosmetic Dermatology, 2025
- [Standardized wild apple fruit extract as a bioactive agent in dermocosmetic products for efficacy skin hydration-In vitro and in vivo evaluation](https://pubmed.ncbi.nlm.nih.gov/35048513/) Pyrus malus fruit extract · Journal of Cosmetic Dermatology, 2022
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites](https://pubmed.ncbi.nlm.nih.gov/23438139/) Retinyl palmitate · Journal of Cosmetic Dermatology, 2013
- [TiO2-embedded mesoporous silica with lower porosity is beneficial to adsorb the pollutants and retard UV filter absorption: A possible application for outdoor skin protection](https://pubmed.ncbi.nlm.nih.gov/36455708/) Avobenzone · European Journal of Pharmaceutical Sciences, 2023
- [Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance](https://pubmed.ncbi.nlm.nih.gov/36502500/) Hexylresorcinol · Archives of Dermatological Research, 2023
- [Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects](https://pubmed.ncbi.nlm.nih.gov/38336313/) Cucumis sativus fruit extract · International Journal of Biological Macromolecules, 2024
- [Amended safety assessment of Sesamum indicum (sesame) seed oil, hydrogenated sesame seed oil, Sesamum indicum (sesame) oil unsaponifiables, and sodium sesameseedate](https://pubmed.ncbi.nlm.nih.gov/21772026/) Sesamum indicum oil · International Journal of Toxicology, 2011
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013
- [Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol](https://pubmed.ncbi.nlm.nih.gov/19514921/) Caprylyl glycol · Cutaneous and Ocular Toxicology, 2009
- [Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging](https://pubmed.ncbi.nlm.nih.gov/38525606/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2024
- [Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/42278371/) Adenosine · International Journal of Molecular Sciences, 2026
- [Functional properties and skin care effects of sodium trehalose sulfate](https://pubmed.ncbi.nlm.nih.gov/38606717/) Trehalose · Skin Research and Technology, 2024
- [A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females](https://pubmed.ncbi.nlm.nih.gov/27272084/) Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride, Capric triglyceride · Life, 2023
- [Improving the outcome of treating striae gravidarum by combined therapies using topical β-glucan and 1565-nm non-ablative fractional laser: A prospective randomized vehicle-controlled parallel group study](https://pubmed.ncbi.nlm.nih.gov/35570397/) Beta-glucan · The Journal of Dermatology, 2022
- [Treatment of Stretch Marks Using a New Formulation Combining Nanofractional Radiofrequency Plus Magnetic Nanofractional Radiofrequency](https://pubmed.ncbi.nlm.nih.gov/37171578/) Beta-glucan · Dermatology and Therapy, 2023
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Evaulation of irritation potential of surfactant mixtures](https://pubmed.ncbi.nlm.nih.gov/18503452/) Sodium laureth sulfate · International Journal of Cosmetic Science, 1999
- [Effects of a Postbiotic Saccharomyces and Lactobacillus Ferment Complex on the Scalp Microbiome of Chinese Women with Sensitive Scalp Syndrome](https://pubmed.ncbi.nlm.nih.gov/37767337/) Lactobacillus ferment · Clinical, Cosmetic and Investigational Dermatology, 2023
- [Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefits](https://pubmed.ncbi.nlm.nih.gov/39964201/) Palmitoyl hexapeptide-12 · ACS Applied Bio Materials, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos](https://pubmed.ncbi.nlm.nih.gov/39769217/) Ascorbyl glucoside · International Journal of Molecular Sciences, 2024
- [A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties](https://pubmed.ncbi.nlm.nih.gov/41562471/) Bakuchiol · Skin Research and Technology, 2026
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Octinoxate · Archives of Dermatological Research, 2024
- [Portulaca oleracea extract relieves skin barrier damage induced by increased photosensitivity after GA peeling](https://pubmed.ncbi.nlm.nih.gov/35920724/) Portulaca oleracea extract purslane extract · Cutaneous and Ocular Toxicology, 2022
- [Topical application of retinyl propionate, 4 hexyl resorcinol, and niacinamide reverses molecular and clinical features of ageing](https://pubmed.ncbi.nlm.nih.gov/38685700/) Retinyl propionate · International Journal of Cosmetic Science, 2024
- [Retinyl propionate and climbazole combination demonstrates clinical improvement to the appearance of hyperpigmentation and deep wrinkling with minimal irritation](https://pubmed.ncbi.nlm.nih.gov/28733999/) Retinyl propionate · International Journal of Cosmetic Science, 2017
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging](https://pubmed.ncbi.nlm.nih.gov/39394831/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025
- [Impact of Hydrocolloid Dressing and Moisturizing Cream as Facial Skin Protectants Among Health Care Workers](https://pubmed.ncbi.nlm.nih.gov/38771104/) Dimethicone · Military Medicine, 2024
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026
- [Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study](https://pubmed.ncbi.nlm.nih.gov/42617898/) Sodium laureth sulfate · International Journal of Pharmaceutics, 2026
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter, Shea butter · Lasers in Medical Science, 2025
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025
- [Low-temperature extracted Portulaca oleracea L. as a functional ingredient in facial masks for photorejuvenation of sensitive skin](https://pubmed.ncbi.nlm.nih.gov/41182319/) Portulaca oleracea extract purslane extract · Cutaneous and Ocular Toxicology, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [A novel facial moisturizer containing Saccharide isomerate accelerates skin barrier restoration following intense pulsed light treatment: a randomized split-face study](https://pubmed.ncbi.nlm.nih.gov/41211697/) Saccharide isomerate · The Journal of Dermatological Treatment, 2025
- [The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies](https://pubmed.ncbi.nlm.nih.gov/41668671/) Laminaria digitata extract · International Journal of Cosmetic Science, 2026
- [Clinical Efficacy of Topical Ascorbic Acid 2-Glucoside in Enhancing Outcomes of Laser Gingival Depigmentation: A Randomized Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42147661/) Ascorbyl glucoside · Cureus, 2026
- [Simmondsia chinensis (jojoba) cake fermentation: A new, sustainable technology for advanced skin and scalp care ingredients](https://pubmed.ncbi.nlm.nih.gov/42698229/) Lactobacillus ferment · International Journal of Cosmetic Science, 2026

## The brands

- American skincare: [Paula's Choice](https://lovi.care/skincare/ie/brands/paula-s-choice)
- American skincare: [Clinique](https://lovi.care/skincare/ie/brands/clinique)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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- United States: https://lovi.care/skincare/compare/paula-s-choice-vs-clinique
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- Ireland: https://lovi.care/skincare/ie/compare/paula-s-choice-vs-clinique (this page)
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- United Arab Emirates: https://lovi.care/skincare/ae/compare/paula-s-choice-vs-clinique