# La Roche-Posay vs MAC

Page: https://lovi.care/skincare/ie/compare/la-roche-posay-vs-mac

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

La Roche-Posay and MAC are distinct beauty brands with unique formulations, where the French skincare line established in 1975 features nourishing [serums](https://lovi.care/skincare/ie/ingredients/serum), rich moisturizers, gentle cleansers, and targeted eye products formulated with [glycerin](https://lovi.care/skincare/ie/ingredients/glycerin), soothing [thermal water](https://lovi.care/skincare/ie/ingredients/thermal-water), and [niacinamide](https://lovi.care/skincare/ie/ingredients/niacinamide) to suit mature skin and skin with dark spots best, while the Canadian brand founded in 1984 is beloved for its thoughtful approach to daily skincare, offering reliable moisturizers and makeup removers crafted from carefully balanced formulas that suit balanced skin best. Both companies bring distinct qualities to everyday routines, though the former relies heavily on specialized active ingredients to address specific concerns like hyperpigmentation and barrier restoration, whereas the latter provides a calm and measured foundation for daily maintenance.

La Roche-Posay is a French skincare brand founded in 1975 and owned by L'Oréal S.A. since 1989.

[laroche-posay.com.au](https://www.laroche-posay.com.au/our-commitments/history.html) [fr.wikipedia.org](https://fr.wikipedia.org/wiki/L%27Or%C3%A9al)

MAC is a Canadian skincare brand founded in 1984 and owned by The Estée Lauder Companies Inc. since 1994.

[elcompanies.com](https://www.elcompanies.com/en-gb/our-brands/mac) [en.wikipedia.org](https://en.wikipedia.org/wiki/Est%C3%A9e_Lauder_Companies)

This page compares some of the most popular La Roche-Posay and MAC products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgef41ad96ab).

### Popular La Roche-Posay vs MAC products

#### La Roche-Posay

- [Toleriane Double Repair Face Moisturizer](https://lovi.care/skincare/ie/p/la-roche-posay/toleriane-double-repair-face-moisturizer/for/oily-acne-prone-skin) — High fit — [€17.63 at Amazon](https://www.amazon.ie/dp/B07JM3F7H1?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Cicaplast Baume B5+](https://lovi.care/skincare/ie/p/la-roche-posay/cicaplast-baume-b5/for/sensitive-skin) — Superior fit — [€23.12 at Amazon](https://www.amazon.ie/dp/B0BJFLVCZK?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Mela B3 Serum](https://lovi.care/skincare/ie/p/la-roche-posay/mela-b3-serum/for/acne-prone-skin) — High fit — [€49.00 at Amazon](https://www.amazon.ie/dp/B0F3BPVGPM?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Retinol B3 Serum](https://lovi.care/skincare/ie/p/la-roche-posay/retinol-b3-serum/for/dark-spots) — Average fit — [€39.96 at Amazon](https://www.amazon.ie/dp/B07Z9Y4M3C?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Effaclar Medicated Gel Cleanser](https://lovi.care/skincare/ie/p/la-roche-posay/effaclar-medicated-gel-cleanser/for/acne-prone-skin) — High fit
- [Hyalu B5 Serum](https://lovi.care/skincare/ie/p/la-roche-posay/hyalu-b5-serum/for/sensitive-skin) — High fit — [€48.00 at Amazon](https://www.amazon.ie/dp/B0F1G1FLGX?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Lipikar AP+M Triple Repair Moisturizing Cream](https://lovi.care/skincare/ie/p/la-roche-posay/lipikar-ap-m-triple-repair-moisturizing-cream/for/dry-skin) — High fit — [€18.00 at Amazon](https://www.amazon.ie/dp/B08PHCW2DX?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Anthelios](https://lovi.care/skincare/ie/p/la-roche-posay/anthelios/for/dark-spots) — Superior fit — [€31.28 at Amazon](https://www.amazon.ie/dp/B08T19GT85?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)

#### MAC

- [Hyper Real Serumizer](https://lovi.care/skincare/ie/p/mac/hyper-real-serumizer/for/dry-sensitive-skin) — High fit — [€72.91 at Amazon](https://www.amazon.ie/dp/B0BV14LWTN?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Mineralize Timecheck Lotion](https://lovi.care/skincare/ie/p/mac/mineralize-timecheck-lotion/for/dry-skin) — High fit
- [Hyper Real Fresh Canvas Cleansing Oil](https://lovi.care/skincare/ie/p/mac/hyper-real-fresh-canvas-cleansing-oil/for/dry-sensitive-skin) — High fit

## People Say

La Roche-Posay

MAC

- Hydration and Moisture Mostly Mentioned Mostly Mentioned “absorbs quickly — MAC Hyper Real Serumizer” “Absorbs in a snap — MAC Mineralize Timecheck Lotion” “Leaves skin feeling soft and supple, never tight. — MAC Hyper Real Fresh Canvas Cleansing Oil” “absorbs instantly — La Roche-Posay Toleriane Double Repair Face Moisturizer”
- Makeup Base and Primer Rarely Noted Mostly Mentioned “foundation glides on — MAC Hyper Real Serumizer” “Sits beautifully under makeup — MAC Mineralize Timecheck Lotion” “Reduces appearance of pores — MAC Mineralize Timecheck Lotion” “makeup sits perfectly — La Roche-Posay Anthelios”
- Sensitive Skin Care and Soothing Mostly Mentioned Sometimes Noted “Only cream that doesn't sting — La Roche-Posay Toleriane Dermallergo Eye Cream” “Calmed my skin after a chemical peel — La Roche-Posay Thermal Spring Water” “no stinging — La Roche-Posay Toleriane Double Repair Face Moisturizer” “Does not cause breakouts — MAC Mineralize Timecheck Lotion”
- Skin Texture Improvement Often Mentioned Sometimes Noted “Skin feels smoother — La Roche-Posay Retinol B3 Serum” “softens forehead lines — La Roche-Posay Hyalu B5 Serum” “Skin feels softer — La Roche-Posay Pure Vitamin C10 Serum” “petal-soft skin — MAC Hyper Real Serumizer”
- Price and Value Sometimes Noted Mostly Mentioned “expensive for the size — La Roche-Posay Hyalu B5 Serum” “Too expensive for the size — La Roche-Posay Toleriane Dermallergo Eye Cream” “Tube is tiny for the price — La Roche-Posay Cicaplast Gel B5” “too expensive — MAC Hyper Real Serumizer”
- Fragrance and Scent Sometimes Noted Often Mentioned “scent is awful — La Roche-Posay Mela B3 Serum” “overwhelming floral smell — La Roche-Posay Hyalu B5 Serum” “scent is overpowering — MAC Hyper Real Serumizer” “Has a scent that might irritate very sensitive noses. — MAC Hyper Real Fresh Canvas Cleansing Oil”
- Product Pilling and Texture Issues Often Mentioned Rarely Noted “Felt sticky to me — MAC Mineralize Timecheck Lotion” “pills like crazy — La Roche-Posay Toleriane Double Repair Face Moisturizer”
- Skin Irritation and Stinging Sometimes Noted Sometimes Noted “burns my eyes — La Roche-Posay Anthelios” “burned my face — La Roche-Posay Toleriane Double Repair Face Moisturizer” “caused acne — MAC Hyper Real Serumizer” “Stings if it accidentally gets into the eyes. — MAC Hyper Real Fresh Canvas Cleansing Oil”
- Packaging and Pump Issues Often Mentioned Not noted “pump stops working — La Roche-Posay Lipikar AP+M Triple Repair Moisturizing Cream”

## Questions and answers

### La Roche-Posay or MAC: which is better?

La Roche-Posay does better than MAC for sensitive skin care, soothing, and skin texture improvement. Reviewers note that the products on this page offer gentle and effective [serums](https://lovi.care/skincare/ie/ingredients/serum) as well as soothing and sensitive-skin friendly moisturizers.

### What is the difference between La Roche-Posay and MAC?

La Roche-Posay is founded in France in 1975 and fits mature skin, skin with dark spots, and dry skin best, whereas MAC is founded in Canada in 1984. La Roche-Posay does better in sensitive skin care and soothing as well as skin texture improvement, while MAC does better in hydration and moisture and makeup base and primer.

### La Roche-Posay or MAC: which moisturizer is better?

La Roche-Posay offers a much wider range of moisturizers with specialized fit levels for different skin types compared to MAC, which features only two moisturizers on this page.

### Which is more affordable, La Roche-Posay or MAC?

La Roche-Posay does better than MAC on price and value, although review themes show price and value concerns for La Roche-Posay and a high price point for MAC.

### Which causes fewer breakouts, La Roche-Posay or MAC?

La Roche-Posay helps acne-prone skin better than MAC, as its products on this page have High fits for acne-prone skin.

### Between La Roche-Posay and MAC, which brand performs better for sensitive skin care and soothing?

La Roche-Posay performs better for sensitive skin care and soothing. The products on this page for La Roche-Posay feature key ingredients like [thermal water](https://lovi.care/skincare/ie/ingredients/thermal-water) and [niacinamide](https://lovi.care/skincare/ie/ingredients/niacinamide), which help soothe the skin.

### How do the fragrance profiles of La Roche-Posay and MAC skincare products compare?

La Roche-Posay offers a mix of fragranced and fragrance-free options, with 21 out of 35 products on this page listing no fragrance. In contrast, all 3 MAC products on this page contain fragrance.

### Which brand is better suited for skin texture improvement?

La Roche-Posay does better for skin texture improvement than MAC. Niacinamide helps control skin aging and pigmentation.

[Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol, Vitamin b5 · American Journal of Clinical Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Regulatory effects of Lactobacillus plantarum-GMNL6 on human skin health by improving skin microbiome](https://pubmed.ncbi.nlm.nih.gov/33526970/) Lactobacillus · International Journal of Medical Sciences, 2021
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol, Ascorbic acid, Tocopherol vitamin e · Journal of Cosmetic Dermatology, 2020
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Vesicular carriers containing phenylethyl resorcinol for topical delivery system; liposomes, transfersomes and invasomes](https://pubmed.ncbi.nlm.nih.gov/32104421/) Phenylethyl resorcinol · Asian Journal of Pharmaceutical Sciences, 2018
- [Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract](https://pubmed.ncbi.nlm.nih.gov/27168678/) Madecassoside · Indian Journal of Pharmaceutical Sciences, 2016
- [Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin](https://pubmed.ncbi.nlm.nih.gov/33037252/) Squalane · Scientific Reports, 2020
- [Effect of Camellia japonica oil on human type I procollagen production and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/17386986/) Camellia japonica seed oil · Journal of Ethnopharmacology, 2007
- [Vitamin C mesotherapy versus topical application for gingival hyperpigmentation: a clinical and histopathological study](https://pubmed.ncbi.nlm.nih.gov/33966113/) Ascorbic acid · Clinical Oral Investigations, 2021
- [Ethosomes of Phenylethyl Resorcinol as Vesicular Delivery System for Skin Lightening Applications](https://pubmed.ncbi.nlm.nih.gov/28804723/) Phenylethyl resorcinol · BioMed Research International, 2017
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Tocopherol, Ascorbic acid, Tocopherol vitamin e · Journal of Cosmetic Dermatology, 2020
- [Efficacy of probiotic-derived lotion from Lactobacillus paracasei MSMC 39-1 in mild to moderate acne vulgaris, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/35384257/) Lactobacillus · Journal of Cosmetic Dermatology, 2022
- [Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin](https://pubmed.ncbi.nlm.nih.gov/18503551/) Centella asiatica leaf extract · Experimental Dermatology, 2008
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32310680/) Madecassoside · Journal of Alternative and Complementary Medicine, 2020
- [Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison](https://pubmed.ncbi.nlm.nih.gov/29549588/) Adapalene usp retinoid acne treatment, Adapalene · American Journal of Clinical Dermatology, 2018
- [Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug](https://pubmed.ncbi.nlm.nih.gov/34674160/) Adapalene, Adapalene usp retinoid acne treatment · American Journal of Clinical Dermatology, 2022
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol, Vitamin b5 · The Journal of Dermatological Treatment, 2017
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration](https://pubmed.ncbi.nlm.nih.gov/29574973/) Adenosine · International Journal of Cosmetic Science, 2018
- [A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/34251536/) Adapalene, Adapalene usp retinoid acne treatment · Archives of Dermatological Research, 2022
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Panthenol, Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Gluconolactone · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Self-Assembled Cubic Liquid Crystalline Nanoparticles for Transdermal Delivery of Paeonol](https://pubmed.ncbi.nlm.nih.gov/26517086/) Paeonia albiflora flower extract · Medical Science Monitor, 2015
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Paeonia albiflora flower extract · Molecules, 2023
- [A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne](https://pubmed.ncbi.nlm.nih.gov/1303072/) Gluconolactone · The Australasian Journal of Dermatology, 1992
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc · Journal of Controlled Release, 2025
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study](https://pubmed.ncbi.nlm.nih.gov/22585103/) Jojoba seed oil · Forschende Komplementarmedizin, 2012
- [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin](https://pubmed.ncbi.nlm.nih.gov/26805418/) Neurosensine · Journal of the European Academy of Dermatology and Venereology, 2016
- [A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial](https://pubmed.ncbi.nlm.nih.gov/25914553/) Ginkgo biloba extract · Clinical, Cosmetic and Investigational Dermatology, 2015
- [2-Mercaptonicotinoyl glycine prevents UV-induced skin darkening and delayed tanning in healthy subjects: A randomized controlled clinical study](https://pubmed.ncbi.nlm.nih.gov/38372022/) 2-mercaptonicotinoyl glycine · Journal of Cosmetic Dermatology, 2024
- [A Bayesian network meta-analysis of 14 molecules inhibiting UV daylight-induced pigmentation](https://pubmed.ncbi.nlm.nih.gov/38433524/) 2-mercaptonicotinoyl glycine · Journal of the European Academy of Dermatology and Venereology, 2024
- [Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials](https://pubmed.ncbi.nlm.nih.gov/37656094/) Adapalene · Journal of the American Academy of Dermatology, 2023
- [Efficacy and Tolerability of Topical Nicotinamide Plus Antibacterial Adhesive Agents and Zinc-Pyrrolidone Carboxylic Acid Versus Placebo as an Adjuvant Treatment for Moderate Acne Vulgaris in Indonesia: A Multicenter, Double-blind, Randomized, Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32983333/) Zinc pca · The Journal of Clinical and Aesthetic Dermatology, 2020
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study](https://pubmed.ncbi.nlm.nih.gov/36698447/) Zinc gluconate · Clinical, Cosmetic and Investigational Dermatology, 2023
- [Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)](https://pubmed.ncbi.nlm.nih.gov/11278060/) Sodium laureth sulfate · Food and Chemical Toxicology, 2001
- [Subclinical cutaneous inflammation remained after permeability barrier disruption enhances UV sensitivity by altering ER stress responses and topical pseudoceramide prevents them](https://pubmed.ncbi.nlm.nih.gov/28631090/) Ceramide ng · Archives of Dermatological Research, 2017
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/33617668/) Capryloyl salicylic acid, Citric acid · Journal of Cosmetic Dermatology, 2021
- [Amino acid complex (AAComplex) benefits in cosmetic products: In vitro and in vivo clinical studies](https://pubmed.ncbi.nlm.nih.gov/34694692/) Complex amino acid · Journal of Cosmetic Dermatology, 2022
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [Clinical tolerance and efficacy of capryloyl salicylic acid peel compared to a glycolic acid peel in subjects with fine lines/wrinkles and hyperpigmented skin](https://pubmed.ncbi.nlm.nih.gov/19146601/) Capryloyl salicylic acid · Journal of Cosmetic Dermatology, 2008
- [Comparative benefit of two thermal spring waters after photodynamic therapy procedure](https://pubmed.ncbi.nlm.nih.gov/17348993/) La roche-posay thermal spring water · Journal of Cosmetic Dermatology, 2007
- [Zinc(II) Complexes of Amino Acids as New Active Ingredients for Anti-Acne Dermatological Preparations](https://pubmed.ncbi.nlm.nih.gov/33561977/) Complex amino acid · International Journal of Molecular Sciences, 2021
- [Partially purified paeoniflorin exerts protective effects on UV-induced DNA damage and reduces facial wrinkles in human skin](https://pubmed.ncbi.nlm.nih.gov/16676123/) Paeonia albiflora flower extract · Journal of Cosmetic Science, 2006
- [Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment](https://pubmed.ncbi.nlm.nih.gov/38460769/) Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024
- [Comprehensive assessment of the efficacy and safety of a clay mask in oily and acne skin](https://pubmed.ncbi.nlm.nih.gov/38009030/) Argilla · Skin Research and Technology, 2023
- [Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast](https://pubmed.ncbi.nlm.nih.gov/40363772/) Squalane · Molecules, 2025
- [A dermocosmetic formulation containing Vichy volcanic mineralizing water, Vitreoscilla filiformis extract, niacinamide, hyaluronic acid, and vitamin E regenerates and repairs acutely stressed skin](https://pubmed.ncbi.nlm.nih.gov/34979590/) Vitreoscilla ferment · Journal of the European Academy of Dermatology and Venereology, 2022
- [Comparison of methods for assessing photoprotection against ultraviolet A in vivo](https://pubmed.ncbi.nlm.nih.gov/3819071/) Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987
- [Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters](https://pubmed.ncbi.nlm.nih.gov/31437563/) Butyl methoxydibenzoylmethane · International Journal of Pharmaceutics, 2019
- [Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis](https://pubmed.ncbi.nlm.nih.gov/37763018/) Yeast extract · Journal of Clinical Medicine, 2023
- [A controlled, three-part trial to investigate the barrier function and skin hydration properties of six skin protectants](https://pubmed.ncbi.nlm.nih.gov/16439809/) Dimethicone · Ostomy/wound Management, 2005
- [Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters](https://pubmed.ncbi.nlm.nih.gov/40227214/) Octocrylene · Antioxidants, 2025
- [A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo](https://pubmed.ncbi.nlm.nih.gov/33811776/) Shea butter · Journal of Cosmetic Dermatology, 2022
- [Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles](https://pubmed.ncbi.nlm.nih.gov/32783330/) Phenylethyl resorcinol · Journal of Cosmetic Dermatology, 2021
- [Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid](https://pubmed.ncbi.nlm.nih.gov/20367666/) Pha polyhydroxy acid · Journal of Cosmetic Dermatology, 2010
- [Topical prevention from high energy visible light-induced pigmentation by 2-mercaptonicotinoyl glycine, but not by ascorbic acid antioxidant: 2 randomized controlled trials](https://pubmed.ncbi.nlm.nih.gov/41142247/) 2-mercaptonicotinoyl glycine · Frontiers in Pharmacology, 2025
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol, Vitamin b5 · Journal of Cosmetic Dermatology, 2025
- [A multicenter, double-blind study to evaluate the efficacy and safety of 2 treatments in participants with mild to moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/22838094/) Micro-exfoliating lha · Cutis, 2012
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays](https://pubmed.ncbi.nlm.nih.gov/34771112/) Propanediol · Molecules, 2021
- [Protective properties of Avène Thermal Spring Water on biomechanical, ultrastructural and clinical parameters of human skin](https://pubmed.ncbi.nlm.nih.gov/32870553/) Prebiotic thermal water, La roche-posay thermal spring water, Thermal spring water · Journal of the European Academy of Dermatology and Venereology, 2020
- [Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/23545907/) Capryloyl salicylic acid · Journal of Drugs in Dermatology, 2013
- [Histometric assessment of the age-related skin response to 2-hydroxy-5-octanoyl benzoic acid](https://pubmed.ncbi.nlm.nih.gov/9603669/) Capryloyl salicylic acid · Skin Pharmacology and Applied Skin Physiology, 1998
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Evaulation of irritation potential of surfactant mixtures](https://pubmed.ncbi.nlm.nih.gov/18503452/) Sodium laureth sulfate · International Journal of Cosmetic Science, 1999
- [Impact of Hydrocolloid Dressing and Moisturizing Cream as Facial Skin Protectants Among Health Care Workers](https://pubmed.ncbi.nlm.nih.gov/38771104/) Dimethicone · Military Medicine, 2024
- [Effects of Malaysian thermal spring water as adjunct therapy for mild to moderate acne vulgaris - a prospective, randomised, controlled, split face study](https://pubmed.ncbi.nlm.nih.gov/38553920/) Prebiotic thermal water, La roche-posay thermal spring water, Thermal spring water, La roche-posay prebiotic thermal water, Thermal water · The Medical Journal of Malaysia, 2024
- [Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/36999489/) Micro-exfoliating lha · Journal of Cosmetic Dermatology, 2023
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Ethylhexyl salicylate · Archives of Dermatological Research, 2024
- [Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study](https://pubmed.ncbi.nlm.nih.gov/41487026/) Zinc gluconate · Journal of Cosmetic Dermatology, 2026
- [A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen](https://pubmed.ncbi.nlm.nih.gov/15002657/) Pha polyhydroxy acid · Cutis, 2004
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025
- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Ethylhexyl salicylate, Homosalate · Journal of Drugs in Dermatology, 2025
- [Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study](https://pubmed.ncbi.nlm.nih.gov/42617898/) Sodium laureth sulfate · International Journal of Pharmaceutics, 2026
- [Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters](https://pubmed.ncbi.nlm.nih.gov/37357656/) Gluconolactone · Skin Research and Technology, 2023
- [Effects of an ultraviolet B radiation absorber on photocarcinogenesis in hairless albino mice](https://pubmed.ncbi.nlm.nih.gov/19365102/) Ethylhexyl triazone · Skin Pharmacology and Physiology, 2009
- [In vitro analysis of immunoprotective effects of topical sunscreens](https://pubmed.ncbi.nlm.nih.gov/20693002/) Ethylhexyl triazone · Toxicology in Vitro, 1994

## The brands

- French skincare: [La Roche-Posay](https://lovi.care/skincare/ie/brands/la-roche-posay)
- Canadian skincare: [MAC](https://lovi.care/skincare/ie/brands/mac)

## More comparisons

- [SKIN1004 vs La Roche-Posay](https://lovi.care/skincare/ie/compare/skin1004-vs-la-roche-posay)
- [SKIN1004 vs MAC](https://lovi.care/skincare/ie/compare/skin1004-vs-mac)
- [Anua vs La Roche-Posay](https://lovi.care/skincare/ie/compare/anua-vs-la-roche-posay)
- [Anua vs MAC](https://lovi.care/skincare/ie/compare/anua-vs-mac)
- [Medicube vs La Roche-Posay](https://lovi.care/skincare/ie/compare/medicube-vs-la-roche-posay)
- [Medicube vs MAC](https://lovi.care/skincare/ie/compare/medicube-vs-mac)
- [The Ordinary vs La Roche-Posay](https://lovi.care/skincare/ie/compare/the-ordinary-vs-la-roche-posay)
- [The Ordinary vs MAC](https://lovi.care/skincare/ie/compare/the-ordinary-vs-mac)
- [Beauty of Joseon vs La Roche-Posay](https://lovi.care/skincare/ie/compare/beauty-of-joseon-vs-la-roche-posay)
- [Beauty of Joseon vs MAC](https://lovi.care/skincare/ie/compare/beauty-of-joseon-vs-mac)
- [COSRX vs La Roche-Posay](https://lovi.care/skincare/ie/compare/cosrx-vs-la-roche-posay)
- [COSRX vs MAC](https://lovi.care/skincare/ie/compare/cosrx-vs-mac)
- [CeraVe vs La Roche-Posay](https://lovi.care/skincare/ie/compare/cerave-vs-la-roche-posay)
- [CeraVe vs MAC](https://lovi.care/skincare/ie/compare/cerave-vs-mac)
- [La Roche-Posay vs Dr. Althea](https://lovi.care/skincare/ie/compare/la-roche-posay-vs-dr-althea)
- [La Roche-Posay vs Some By Mi](https://lovi.care/skincare/ie/compare/la-roche-posay-vs-some-by-mi)
- [La Roche-Posay vs Torriden](https://lovi.care/skincare/ie/compare/la-roche-posay-vs-torriden)
- [La Roche-Posay vs celimax](https://lovi.care/skincare/ie/compare/la-roche-posay-vs-celimax)
- [La Roche-Posay vs Purito](https://lovi.care/skincare/ie/compare/la-roche-posay-vs-purito)
- [La Roche-Posay vs Cetaphil](https://lovi.care/skincare/ie/compare/la-roche-posay-vs-cetaphil)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/la-roche-posay-vs-mac
- United Kingdom: https://lovi.care/skincare/uk/compare/la-roche-posay-vs-mac
- Ireland: https://lovi.care/skincare/ie/compare/la-roche-posay-vs-mac (this page)
- Germany: https://lovi.care/skincare/de/compare/la-roche-posay-vs-mac
- France: https://lovi.care/skincare/fr/compare/la-roche-posay-vs-mac
- Italy: https://lovi.care/skincare/it/compare/la-roche-posay-vs-mac
- Netherlands: https://lovi.care/skincare/nl/compare/la-roche-posay-vs-mac
- Spain: https://lovi.care/skincare/es/compare/la-roche-posay-vs-mac
- Canada: https://lovi.care/skincare/ca/compare/la-roche-posay-vs-mac
- Australia: https://lovi.care/skincare/au/compare/la-roche-posay-vs-mac
- Singapore: https://lovi.care/skincare/sg/compare/la-roche-posay-vs-mac
- Saudi Arabia: https://lovi.care/skincare/sa/compare/la-roche-posay-vs-mac
- United Arab Emirates: https://lovi.care/skincare/ae/compare/la-roche-posay-vs-mac