# DHC vs Sesderma

Page: https://lovi.care/skincare/ie/compare/dhc-vs-sesderma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

DHC and Sesderma are established skincare brands from Japan and Spain respectively, offering distinct approaches to daily beauty rituals. The Japanese brand is known for nourishing formulas and effective makeup removers like the Deep Cleansing Oil, making it well-suited for normal, dry, combination, and oily skin, while the Spanish counterpart specializes in advanced [serums](https://lovi.care/skincare/ie/ingredients/serum) and meticulously engineered formulas like the Azelac RU Serum that cater best to sensitive, hyperpigmented, and aging skin. While both companies provide targeted solutions for acne-prone skin, they differ fundamentally in their heritage, preferred active compounds, and ideal skin types.

DHC is a Japanese skincare brand founded in 1980 and owned by ORIX Corporation since 2023.

[dhc-corporate.co.jp](https://dhc-corporate.co.jp/en/company/message/) [en.wikipedia.org](https://en.wikipedia.org/wiki/DHC_Corporation)

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular DHC and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgc81c098cfe).

### Popular DHC vs Sesderma products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/ie/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€28.32 at Amazon](https://www.amazon.ie/dp/B00987RKWW?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)

#### DHC

- [Deep Cleansing Oil](https://lovi.care/skincare/ie/p/dhc/deep-cleansing-oil/for/dry-skin) — High fit — [€30.90 at Amazon](https://www.amazon.ie/dp/B00KHO5464?tag=lovi-care-web-product02-21&linkCode=osi&th=1&psc=1)
- [Pore Cleansing Oil](https://lovi.care/skincare/ie/p/dhc/pore-cleansing-oil/for/sensitive-skin) — Superior fit

## Questions and answers

### DHC or Sesderma: which is better?

DHC is the better choice for sensitive skin because every product on this page lists no fragrance, whereas Sesderma includes fragrance in its [serum](https://lovi.care/skincare/ie/ingredients/serum). Lovi rates DHC Pore Cleansing Oil as a Superior fit for sensitive skin.

### What is the difference between DHC and Sesderma?

DHC has a High fit for sensitive skin with its Pore Cleansing Oil, while Sesderma has a Low fit for dry skin with its Azelac RU Serum. Furthermore, every product on the DHC page lists no fragrance, whereas the Azelac RU Serum from Sesderma contains fragrance.

### Which is more affordable, DHC or Sesderma?

The page facts do not mention the prices of products from either DHC or Sesderma.

### Which causes fewer breakouts, DHC or Sesderma?

DHC offers better choices for acne-prone skin, as Pore Cleansing Oil achieves a High Lovi fit level for this skin type, while Sesderma's Azelac RU Serum only reaches High. [Azelaic acid](https://lovi.care/skincare/ie/ingredients/azelaic-acid) helps reduce acne vulgaris.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Between DHC and Sesderma, which brand offers products completely free of fragrance?

DHC offers products completely free of fragrance because every product on this page lists no fragrance in its ingredients, whereas Sesderma includes fragrance in its serum.

### How do the founding years and countries of origin compare between DHC and Sesderma?

DHC was founded in Japan in 1980, while Sesderma was founded in Spain in 1989.

### Which brand offers a serum specifically targeted for skin with dark spots?

Sesderma offers a serum specifically targeted for skin with dark spots, with Azelac RU Serum receiving a High Lovi fit level for this skin type.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Efficacy and Tolerability of Topical Nicotinamide Plus Antibacterial Adhesive Agents and Zinc-Pyrrolidone Carboxylic Acid Versus Placebo as an Adjuvant Treatment for Moderate Acne Vulgaris in Indonesia: A Multicenter, Double-blind, Randomized, Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32983333/) Zinc pca · The Journal of Clinical and Aesthetic Dermatology, 2020
- [Formulation strategies to modulate the topical delivery of anti-inflammatory compounds](https://pubmed.ncbi.nlm.nih.gov/24139433/) Stearyl glycyrrhetinate · Journal of Cosmetic Science, 2013
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 3-o-ethyl ascorbic acid · Polymers, 2023
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026

## The brands

- Japanese skincare: [DHC](https://lovi.care/skincare/ie/brands/dhc)
- Spanish skincare: [Sesderma](https://lovi.care/skincare/ie/brands/sesderma)

## More comparisons

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- [SKIN1004 vs Sesderma](https://lovi.care/skincare/ie/compare/skin1004-vs-sesderma)
- [Anua vs DHC](https://lovi.care/skincare/ie/compare/anua-vs-dhc)
- [Anua vs Sesderma](https://lovi.care/skincare/ie/compare/anua-vs-sesderma)
- [Medicube vs DHC](https://lovi.care/skincare/ie/compare/medicube-vs-dhc)
- [Medicube vs Sesderma](https://lovi.care/skincare/ie/compare/medicube-vs-sesderma)
- [The Ordinary vs DHC](https://lovi.care/skincare/ie/compare/the-ordinary-vs-dhc)
- [The Ordinary vs Sesderma](https://lovi.care/skincare/ie/compare/the-ordinary-vs-sesderma)
- [Beauty of Joseon vs DHC](https://lovi.care/skincare/ie/compare/beauty-of-joseon-vs-dhc)
- [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/ie/compare/beauty-of-joseon-vs-sesderma)
- [COSRX vs DHC](https://lovi.care/skincare/ie/compare/cosrx-vs-dhc)
- [COSRX vs Sesderma](https://lovi.care/skincare/ie/compare/cosrx-vs-sesderma)
- [CeraVe vs DHC](https://lovi.care/skincare/ie/compare/cerave-vs-dhc)
- [CeraVe vs Sesderma](https://lovi.care/skincare/ie/compare/cerave-vs-sesderma)
- [La Roche-Posay vs DHC](https://lovi.care/skincare/ie/compare/la-roche-posay-vs-dhc)
- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/ie/compare/la-roche-posay-vs-sesderma)
- [Dr. Althea vs DHC](https://lovi.care/skincare/ie/compare/dr-althea-vs-dhc)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/ie/compare/dr-althea-vs-sesderma)
- [Some By Mi vs DHC](https://lovi.care/skincare/ie/compare/some-by-mi-vs-dhc)
- [Some By Mi vs Sesderma](https://lovi.care/skincare/ie/compare/some-by-mi-vs-sesderma)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/dhc-vs-sesderma
- United Kingdom: https://lovi.care/skincare/uk/compare/dhc-vs-sesderma
- Ireland: https://lovi.care/skincare/ie/compare/dhc-vs-sesderma (this page)
- Germany: https://lovi.care/skincare/de/compare/dhc-vs-sesderma
- France: https://lovi.care/skincare/fr/compare/dhc-vs-sesderma
- Italy: https://lovi.care/skincare/it/compare/dhc-vs-sesderma
- Netherlands: https://lovi.care/skincare/nl/compare/dhc-vs-sesderma
- Spain: https://lovi.care/skincare/es/compare/dhc-vs-sesderma
- Canada: https://lovi.care/skincare/ca/compare/dhc-vs-sesderma
- Australia: https://lovi.care/skincare/au/compare/dhc-vs-sesderma
- Singapore: https://lovi.care/skincare/sg/compare/dhc-vs-sesderma
- Saudi Arabia: https://lovi.care/skincare/sa/compare/dhc-vs-sesderma
- United Arab Emirates: https://lovi.care/skincare/ae/compare/dhc-vs-sesderma