# Advanced Clinicals skincare

Page: https://lovi.care/skincare/ie/brands/advanced-clinicals

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Ireland.

Advanced Clinicals is an American skincare brand founded in 2005 and owned by Concept Laboratories, Inc..

[tracxn.com](https://tracxn.com/d/companies/advanced-clinicals/__5SAKCpIAzQ6c5NRt4-PNS8xWIapHacc9Q2SepTdbIfM)

Advanced Clinicals is widely loved for its thoughtful moisturizers and [serums](https://lovi.care/skincare/ie/ingredients/serum), relying on effective formulas. Its products suit dry, oily, combination, and sensitive skin best, as these formulas adapt easily to various needs. For distinct concerns, the brand offers standout options including the [Vitamin C](https://lovi.care/skincare/ie/ingredients/vitamin-c) Brightening Gel-Cream for acne-prone skin, the Vitamin C Anti Aging Serum for skin with dark spots, and the [Retinol](https://lovi.care/skincare/ie/ingredients/retinol) Advanced Firming Cream for mature skin.

This page covers some of the most popular Advanced Clinicals products; for the whole Advanced Clinicals range, with a fit score for every product, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=brand&af_sub3=selection_note&af_sub4=pgcfe307f7b1).

### Other Advanced Clinicals products

#### Other products

- [Retinol Advanced Firming Cream](https://lovi.care/skincare/ie/p/advanced-clinicals/retinol-advanced-firming-cream/for/mature-skin) — Average fit
- [Vitamin C Anti Aging Serum](https://lovi.care/skincare/ie/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/combination-skin) — Average fit
- [Collagen Skin Rescue Lotion](https://lovi.care/skincare/ie/p/advanced-clinicals/collagen-skin-rescue-lotion/for/dry-skin) — Average fit
- [HYALURONIC SERUM](https://lovi.care/skincare/ie/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin) — Average fit
- [Vitamin C Brightening Gel-Cream](https://lovi.care/skincare/ie/p/advanced-clinicals/vitamin-c-brightening-gel-cream/for/mature-skin) — High fit

## People Say

★4.6

Overall rating based on 232.7k+ reviews

Reviewers most often praise Advanced Clinicals for enhancing skin texture, deep hydration, and diminishing fine lines. The most common complaints are a drying or dehydrating effect and a slightly sticky finish.

### Highlights

- Great value Mostly Mentioned “huge bottle for the price — Vitamin C Anti Aging Serum” “Amazing quality for the price — Retinol Advanced Firming Cream” “Great value for the size — Collagen Skin Rescue Lotion”
- Improved skin texture and tone Mostly Mentioned “noticeably lightened age spots — Vitamin C Anti Aging Serum” “My skin feels firmer, smoother, and well-hydrated — Retinol Advanced Firming Cream” “reducing the appearance of my laugh lines — HYALURONIC SERUM”
- Deeply hydrating moisturizers Mostly Mentioned “Instantly quenches thirsty skin — Collagen Skin Rescue Lotion” “instant hydration for dry skin — HYALURONIC SERUM”
- Fast-absorbing serums Mostly Mentioned “Absorbs quickly and feels non-greasy — Retinol Advanced Firming Cream” “absorbs quickly — Vitamin C Anti Aging Serum”
- Fast-absorbing moisturizers Mostly Mentioned “Absorbs quickly — Collagen Skin Rescue Lotion” “absorbs well — HYALURONIC SERUM”
- Fragrance-free formulas Often Mentioned “It's fragrance-free, gentle even with retinol — Retinol Advanced Firming Cream” “No added scent — Collagen Skin Rescue Lotion”
- Skin dryness and irritation Often Mentioned “My skin immediately feels dry like it feels dehydrated — Retinol Advanced Firming Cream” “Caused minor breakout — Collagen Skin Rescue Lotion” “dried out my skin — Vitamin C Anti Aging Serum”
- Slightly sticky finish Often Mentioned “It's a little sticky but It absorbs well. — HYALURONIC SERUM” “leaves a sticky residue — Vitamin C Anti Aging Serum”

Sources: lovi.care, iherb.com, walmart.com, retinol.com, gopicky.com, amazon.com, and more

## Questions and answers

### Is Advanced Clinicals worth it?

Yes, Advanced Clinicals is worth it, offering great value and effective moisturizers and [serums](https://lovi.care/skincare/ie/ingredients/serum) that help improve skin texture. Lovi rates the Advanced Clinicals-focused routine Superior for dry, oily, sensitive, combination, and acne-prone skin.

### What are Advanced Clinicals's best products?

Advanced Clinicals's best products are the [Vitamin C](https://lovi.care/skincare/ie/ingredients/vitamin-c) Brightening Gel-Cream and Vitamin C Anti Aging Serum, as Lovi rates them High for skin with dark spots and mature skin. Reviewers also frequently mention that these moisturizers provide deep hydration and leave skin smooth. The Advanced Clinicals products on this page are fragrance-free.

[Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/) [Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/)

### Which Advanced Clinicals moisturizer is best for dry skin?

The Vitamin C Brightening Gel-Cream is the best moisturizer on this page for dry skin, where Lovi rates it High. The [Collagen](https://lovi.care/skincare/ie/ingredients/collagen) Skin Rescue Lotion and HYALURONIC SERUM are also available options, and Lovi rates both as Average for dry skin.

### Does Advanced Clinicals cause breakouts?

Advanced Clinicals is unlikely to cause breakouts when shoppers choose products suited to their skin type, as the Advanced Clinicals products on this page have fragrance-free formulas. Reviewers note that the line offers fast-absorbing serums and moisturizers, though some mention occasional skin dryness and irritation.

### Is Advanced Clinicals fragrance-free?

Yes, every one of the Advanced Clinicals products on this page lists no fragrance in its ingredients. Reviewers often mention that these are fragrance-free formulas.

### What are the key ingredients in Advanced Clinicals products?

Advanced Clinicals products feature key ingredients such as [retinol](https://lovi.care/skincare/ie/ingredients/retinol), vitamin C, and plant [extracts](https://lovi.care/skincare/ie/ingredients/extract) like [green tea](https://lovi.care/skincare/ie/ingredients/green-tea) and [chamomile](https://lovi.care/skincare/ie/ingredients/chamomile). Retinol helps improve aged skin and smooth texture, while vitamin C and antioxidants brighten dark spots and protect against damage.

[The Journal of Investigative Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/10692106/) [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### How do I build a Advanced Clinicals skincare routine?

To build an Advanced Clinicals routine, start with a fast-absorbing serum like the Vitamin C Anti Aging Serum or HYALURONIC SERUM, then follow with a deeply hydrating moisturizer such as the Vitamin C Brightening Gel-Cream or Collagen Skin Rescue Lotion. Lovi rates the Advanced Clinicals-focused routine Superior for dry, oily, sensitive, combination, and acne-prone skin types.

### What are good alternatives to Advanced Clinicals?

Good alternatives to Advanced Clinicals include CeraVe, Cetaphil, Paula's Choice, Neutrogena, Kiehl's, and Dermalogica. These brands also offer skincare options that may fit various skin types.

### Advanced Clinicals vs CeraVe: which is better?

Advanced Clinicals rates Superior for dry, oily, sensitive, combination, and acne-prone skin, while CeraVe rates High for dry skin and Superior for the others. Reviewers mention that the Advanced Clinicals products on this page offer great value and help improve texture and tone, although some note mild dryness or irritation.

### Who owns Advanced Clinicals, and where is it from?

Advanced Clinicals is an American brand founded in 2005, owned by Concept Laboratories, Inc..

[tracxn.com](https://tracxn.com/d/companies/advanced-clinicals/__5SAKCpIAzQ6c5NRt4-PNS8xWIapHacc9Q2SepTdbIfM)

### Is Advanced Clinicals cruelty-free?

PETA, Leaping Bunny, and Cruelty Free International, the registries Lovi checks, do not list Advanced Clinicals as cruelty-free.

## Research behind Advanced Clinicals's key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress](https://pubmed.ncbi.nlm.nih.gov/11181450/) Camellia sinensis · Carcinogenesis, 2001
- [Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes](https://pubmed.ncbi.nlm.nih.gov/23096708/) Camellia sinensis · The Journal of Investigative Dermatology, 2013
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation](https://pubmed.ncbi.nlm.nih.gov/18603326/) Ferulic acid · Journal of the American Academy of Dermatology, 2008
- [Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin](https://pubmed.ncbi.nlm.nih.gov/19146606/) Ferulic acid · Journal of Cosmetic Dermatology, 2008
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo](https://pubmed.ncbi.nlm.nih.gov/27279007/) Chamomile · International Journal of Molecular Medicine, 2016
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topical Application of Epigallocatechin-3-Gallate in the Modulation of Cutaneous Scarring in Human Skin](https://pubmed.ncbi.nlm.nih.gov/30822414/) Camellia sinensis · The Journal of Investigative Dermatology, 2019
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ferulic acid · Journal of Cosmetic Dermatology, 2020
- [Epilobium angustifolium extract demonstrates multiple effects on dermal fibroblasts in vitro and skin photo-protection in vivo](https://pubmed.ncbi.nlm.nih.gov/23817638/) Epilobium angustifolium stem extract flower leaf · General Physiology and Biophysics, 2013
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [In vitro antioxidant, collagenase inhibition, and in vivo anti-wrinkle effects of combined formulation containing Punica granatum, Ginkgo biloba, Ficus carica, and Morus alba fruits extract](https://pubmed.ncbi.nlm.nih.gov/26203268/) Ginkgo biloba leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2015
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Tetrahexyldecyl ascorbate · Photochemistry and Photobiology, 2021
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques](https://pubmed.ncbi.nlm.nih.gov/28385617/) Tetrahexyldecyl ascorbate · European Journal of Pharmaceutics and Biopharmaceutics, 2017
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Apple Extract (Malus sp.) and Rutin as Photochemopreventive Agents: Evaluation of Ultraviolet B-Induced Alterations on Skin Biopsies and Tissue-Engineered Skin](https://pubmed.ncbi.nlm.nih.gov/32242497/) Pyrus malus fruit extract · Rejuvenation Research, 2020
- [Stability, antioxidant activity, in vivo safety and efficacy of creams with standardized wild apple fruit extract: a comparison of conventional and biodegradable emulsifiers](https://pubmed.ncbi.nlm.nih.gov/31050807/) Pyrus malus fruit extract · International Journal of Cosmetic Science, 2019
- [Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial](https://pubmed.ncbi.nlm.nih.gov/40464749/) Ferulic acid · The Journal of Dermatological Treatment, 2025
- [Standardized wild apple fruit extract as a bioactive agent in dermocosmetic products for efficacy skin hydration-In vitro and in vivo evaluation](https://pubmed.ncbi.nlm.nih.gov/35048513/) Pyrus malus fruit extract · Journal of Cosmetic Dermatology, 2022
- [Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation](https://pubmed.ncbi.nlm.nih.gov/37074796/) Ginkgo biloba leaf extract · Drug Development and Industrial Pharmacy, 2023
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging](https://pubmed.ncbi.nlm.nih.gov/38525606/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2024
- [Preliminary evaluation of a comprehensive skincare regimen for enhancing skin health following advanced optimal pulse technology (AOPT) treatment](https://pubmed.ncbi.nlm.nih.gov/40497421/) Ergothioneine · International Journal of Cosmetic Science, 2025
- [Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis](https://pubmed.ncbi.nlm.nih.gov/42698538/) Ergothioneine · Frontiers in Nutrition, 2026

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi rates every product from its full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind these ratings: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/brands/advanced-clinicals
- United Kingdom: https://lovi.care/skincare/uk/brands/advanced-clinicals
- Ireland: https://lovi.care/skincare/ie/brands/advanced-clinicals (this page)
- Germany: https://lovi.care/skincare/de/brands/advanced-clinicals
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