# The INKEY List Polyglutamic Acid Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/fr/p/the-inkey-list/polyglutamic-acid-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [The INKEY List](https://lovi.care/skincare/fr/brands/the-inkey-list)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/fr/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Offers excellent moisturizing for your normal skin, as polyglutamic acid and glycerin provide superior humectant action to hydrate and improve skin elasticity, effectively addressing your concerns with wrinkles and fine lines.
- The serum's formulation is highly suitable for normal skin, with dimethicone and other silicones offering a smooth application and a protective barrier without clogging pores.
- The product is safe for your skin, containing no harsh ingredients and posing no risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/the-inkey-list/polyglutamic-acid-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/fr/p/the-inkey-list/polyglutamic-acid-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/fr/p/the-inkey-list/polyglutamic-acid-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/fr/p/the-inkey-list/polyglutamic-acid-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/fr/p/the-inkey-list/polyglutamic-acid-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/fr/p/the-inkey-list/polyglutamic-acid-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/fr/p/the-inkey-list/polyglutamic-acid-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/the-inkey-list/polyglutamic-acid-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/the-inkey-list/polyglutamic-acid-serum/for/oily-acne-prone-skin): High

## Key ingredients

Polyglutamic Acid, Glycerin, Dimethicone, Butylene Glycol, Rice Bran Extract

## What the research says

- Poly-gamma-glutamic acid derived from a novel Bacillus subtilis strain dose-dependently increased skin barrier markers, hyaluronic acid synthesis, and aquaporin 3 expression in keratinocytes, and elevated filaggrin, involucrin, CD44, and aquaporin 3 expression in a reconstructed skin model compared to the control. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/39940752/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Curcumin-loaded polyglutamic acid and gum arabic electrospun nanofibers accelerated wound healing, increased TGF-beta1 and VEGF expression, reduced inflammatory factors, and enhanced re-epithelialization and tissue regeneration in a mouse model with acute full-thickness skin defects. ([International Journal of Biological Macromolecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38554903/))
- Polyglutamic acid and polylysine composite hydrogels promote wound repair and hemostasis through high water absorption, bioadhesion, calcium ion-mediated coagulation factor activation, and inherent antibacterial properties in a deep skin defect model. ([Macromolecular Bioscience, 2021](https://pubmed.ncbi.nlm.nih.gov/33656254/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups. ([Military Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38771104/))
- Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms. ([Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/))
- Externally applied substances such as ceramides, hyaluronic acid, licorice extracts, dimethicone, petrolatum, and paraffin wax treat skin disease resulting from damage to the skin barrier. ([Clinics in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22507050/))
- Topical gel and cream formulations containing niosomes entrapped with rice bran bioactive compounds improved skin hydration, lightening, thickness, roughness, and elasticity in 30 human volunteers over 28 days compared to baseline. ([Pharmaceutical Biology, 2012](https://pubmed.ncbi.nlm.nih.gov/22235888/))
- Gel and cream formulations containing rice bran bioactive compounds entrapped in niosomes increased in vitro antioxidant activity (ORAC values of 20-28 micromol TE/g versus 16-18 micromol TE/g for placebo), enhanced lipid peroxidation inhibition in human sebum by about 1.5 times, and improved in vivo human skin hydration by approximately 3 to 30% depending on the measurement technique. ([Journal of Nanoscience and Nanotechnology, 2011](https://pubmed.ncbi.nlm.nih.gov/21449379/))
- Stirring Nukadoko fermented rice bran beds by hand leads to temporary settlement of microorganisms on human skin with quick shedding. ([FEMS Microbiology Letters, 2023](https://pubmed.ncbi.nlm.nih.gov/37960971/))

## What reviewers say

Based on a very large amount of data, this serum is frequently praised by users with dry or dehydrated skin for its ability to deeply hydrate and create a smooth, glass-like finish that works well under makeup. Many users find it superior to hyaluronic acid for plumping fine lines. A significant number of reviewers, however, note a strong chemical scent and a pump dispenser that can be difficult to control.

- Liked: Deep hydration (mostly mentioned)
- Liked: Excellent makeup base (often mentioned)
- Liked: Smooth/silky finish (often mentioned)
- Disliked: Unpleasant scent (often mentioned)
- Liked: Plumping effect (sometimes noted)
- Disliked: Poor packaging (sometimes noted)
- Disliked: Skin irritation (rarely noted)
- Disliked: Sticky feel (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes The INKEY List Polyglutamic Acid Serum a great fit for mature skin?

This serum is a great fit because polyglutamic acid and glycerin draw in plenty of moisture to smooth out fine lines and wrinkles. It also feels very smooth on the skin and keeps it protected without clogging pores, while being gentle enough to avoid any irritation.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/39940752/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

Polyglutamic acid and glycerin make this serum a great fit for mature skin by deeply hydrating and smoothing the look of fine lines. Dimethicone also helps by creating a protective barrier that keeps moisture locked in without clogging pores.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/39940752/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Polyglutamic Acid do for mature skin?

Polyglutamic Acid helps boost moisture and strengthens the skin barrier to keep mature skin feeling soft and smooth. It may also support natural hydration factors to improve overall skin condition.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/39940752/)

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, as Lovi routines place treatments at night for simplicity and extra safety around sun exposure. It helps hydrate mature skin and improve elasticity, effectively addressing concerns with wrinkles and fine lines.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/), [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40327583/)

### Can I use this serum with hyaluronic acid, and in what order?

You can use this serum with hyaluronic acid by applying the hyaluronic acid first on slightly damp skin, followed by this serum to lock in extra hydration. This combination helps plump the skin and smooth the look of fine lines without causing irritation.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/39940752/)

### How often should I use this serum?

You can use this serum in your evening routine as part of your regular skin care steps. Daily application helps keep mature skin well hydrated and smooth while reducing the look of fine lines and wrinkles.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it uses silicones that form a protective barrier without blocking pores. It also poses very little risk of skin irritation.

### Can I use this serum around the eyes or on my body?

You can safely use this serum on the thin skin around your eyes and on your body because its gentle formula is unlikely to cause irritation. The product is also well-suited for these areas as it provides deep moisture and helps smooth out fine lines without clogging pores.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/39940752/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Revision Skincare Hydrating Serum](https://lovi.care/skincare/fr/p/revision-skincare/hydrating-serum/for/mature-skin) — High fit — €191.05 at Amazon
- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/fr/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/mature-skin) — High fit — €29.00 at Amazon
- [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/fr/p/isntree/green-tea-fresh-serum/for/mature-skin) — High fit — €12.56 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/mature-skin) — Superior fit — €28.02 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €18.45 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/fr/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — €24.00 at Amazon

## Where to buy

- Amazon.fr: €33.00 (https://www.amazon.fr/dp/B0G539XWHB?tag=lovi-care-web-product06-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Dimethicone, Butylene Glycol, Bis-Peg-12 Dimethicone, Glycerin, Polymethylsilsesquioxane, Polysilicone-11, Phenoxyethanol, Polyglutamic Acid, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Propanediol, Coco-Glucoside, Sodium Benzoate, Hydroxyethylcellulose, Polysorbate 80, Ethylhexylglycerin, Potassium Sorbate, Decyl Glucoside, Dimethylacrylamide Acrylic Acid Polystyrene Ethyl Methacrylate Copolymer, Sorbitan Oleate, Trisodium Ethylenediamine Disuccinate, Caprylyl Glycol, Hexylene Glycol, Rice Bran Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-inkey-list/polyglutamic-acid-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/the-inkey-list/polyglutamic-acid-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/the-inkey-list/polyglutamic-acid-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/the-inkey-list/polyglutamic-acid-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/the-inkey-list/polyglutamic-acid-serum/for/mature-skin (this page)
- Italy: https://lovi.care/skincare/it/p/the-inkey-list/polyglutamic-acid-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/the-inkey-list/polyglutamic-acid-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/the-inkey-list/polyglutamic-acid-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/the-inkey-list/polyglutamic-acid-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/the-inkey-list/polyglutamic-acid-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/the-inkey-list/polyglutamic-acid-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/the-inkey-list/polyglutamic-acid-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/the-inkey-list/polyglutamic-acid-serum/for/mature-skin