# SkinMedica TNS Advanced+ Serum for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/fr/p/skinmedica/tns-advanced-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [SkinMedica](https://lovi.care/skincare/fr/brands/skinmedica)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for skin with dark spots; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin due to the presence of Human Fibroblast Conditioned Media and Whey Protein, which support collagen stimulation and barrier repair.
- It offers excellent skin rejuvenation with Trifluoroacetyl Tripeptide-2, improving skin texture and reducing fine lines, though it lacks targeted ingredients for your main goal of pigmentation.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like Glycerin and Shea Ethyl Esters Butter.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/skinmedica/tns-advanced-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/fr/p/skinmedica/tns-advanced-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/fr/p/skinmedica/tns-advanced-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/fr/p/skinmedica/tns-advanced-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/skinmedica/tns-advanced-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/fr/p/skinmedica/tns-advanced-serum/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/fr/p/skinmedica/tns-advanced-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/skinmedica/tns-advanced-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/skinmedica/tns-advanced-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Human Fibroblast Conditioned Media, Collagen Peptides, Trifluoroacetyl Tripeptide-2, Glycerin, Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract

## What the research says

- Topical application of human fibroblast conditioned media and its derived growth factors and exosomes significantly reduces signs of skin aging and stimulates skin recovery and quality after in-office cosmetic procedures. ([Dermatologic Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/39480036/))
- A porous functionally graded scaffold based on κ-carrageenan, arginine, and whey protein isolate was designed and developed for the management of chronic skin wounds, with cell migration, adhesion, and proliferation evaluated in vitro on fibroblasts and wound healing potential studied in vivo on a murine model. ([International Journal of Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/38621616/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32390321/))
- Exposure to collagen peptides increased the expression of COL1A1, ELN, and VCAN genes and collagen protein levels in cultured human dermal fibroblasts compared to untreated controls. ([Frontiers in Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38751975/))
- Salmo salar and Tilapia nilotica skin collagen peptides accelerate wound healing in a rat murine wound model by reducing proinflammatory cytokines, upregulating BD14, NOD2, IL-10, VEGF, and beta-FGF, and favorably altering wound microflora colonization compared to untreated controls. ([Journal of Agricultural and Food Chemistry, 2020](https://pubmed.ncbi.nlm.nih.gov/31967468/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised for its potent anti-aging benefits, specifically targeting coarse wrinkles, fine lines, and sagging skin to produce a firmer, more radiant complexion. Users frequently report visible improvements in skin texture and elasticity. However, the product's high price tag and recurring issues with its dual-chamber pump packaging are common points of frustration.

- Liked: Improves fine lines (mostly mentioned)
- Disliked: Very expensive price (mostly mentioned)
- Liked: Firms sagging skin (often mentioned)
- Liked: Smoothes skin texture (often mentioned)
- Disliked: Faulty pump dispenser (often mentioned)
- Liked: Safe for sensitive skin (sometimes noted)
- Disliked: Uneven product dispensing (sometimes noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes SkinMedica TNS Advanced+ Serum a great fit for skin with dark spots?

SkinMedica TNS Advanced+ Serum is a great fit because it supports collagen stimulation and barrier repair with Human Fibroblast Conditioned Media and whey protein, while improving texture using Trifluoroacetyl Tripeptide-2. It also has a very safe profile with zero risk of irritation due to soothing components like glycerin and shea butter, though it does not contain targeted ingredients specifically for dark spots.
Sources: [Dermatologic Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/39480036/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for skin with dark spots?

This serum is a great fit for your normal skin because Human Fibroblast Conditioned Media and Whey Protein support collagen stimulation and barrier repair. It also rejuvenates skin with Trifluoroacetyl Tripeptide-2 to improve texture and reduce fine lines, though it lacks targeted ingredients for your main goal of pigmentation.
Sources: [Dermatologic Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/39480036/)

### What does Human Fibroblast Conditioned Media do for skin with dark spots?

Human Fibroblast Conditioned Media helps support skin recovery and may influence dark spots by regulating melanin production and cell activity. It is unlikely to cause irritation and is often used in routines targeting uneven tone and signs of aging.
Sources: [Dermatologic Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/39480036/), [Pigment Cell Research, 2006](https://pubmed.ncbi.nlm.nih.gov/16965272/)

### What do Collagen Peptides do for skin with dark spots?

Collagen peptides help fade dark spots and reduce redness by safely suppressing skin pigmentation with daily intake over three months. This helps keep skin looking even and clear.
Sources: [Dermatology and Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/35696023/)

### Where does this serum go in a skincare routine for skin with dark spots?

This treatment serum goes in your evening routine after cleansing and before moisturizing. Putting it on at night keeps things simple and avoids extra safety concerns with sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this treatment first in your evening routine, followed by your retinol. This approach is unlikely to cause irritation because the serum contains soothing ingredients like glycerin and shea ethyl esters butter that help keep skin calm.

### How often should I use this serum?

You can use this serum in the evening as part of your routine. It is a great fit for your skin and helps improve texture, while being unlikely to cause irritation.
Sources: [Dermatologic Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/39480036/), [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to clog pores, cause breakouts, or lead to purging, as it has a very safe formula free of harsh ingredients and includes soothing components like glycerin and shea butter derivatives. It is well tolerated by the skin, helping to keep it smooth and calm without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots) — Superior fit — €57.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/fr/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dark-spots) — High fit — €18.25 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/fr/p/la-mer/the-regenerating-serum/for/dark-spots) — High fit — €25.57 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/fr/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €11.35 at Amazon
- Hydrating Toner: [La Mer The Tonic](https://lovi.care/skincare/fr/p/la-mer/the-tonic/for/dark-spots) — Superior fit — €10.25 at Amazon
- Moisturizer: [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/fr/p/isntree/green-tea-fresh-serum/for/dark-spots) — Superior fit — €12.56 at Amazon

## Where to buy

No store in France has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Ethyl Esters Butter, Glycerin, Ethoxydiglycol, Lactococcus Lysate Ferment, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Trifluoroacetyl Tripeptide-2, Dimer Tripeptide-43, Hydrolyzed Linseed Extract, Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, Peg-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Dextran, Disodium Edta, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skinmedica/tns-advanced-serum/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/skinmedica/tns-advanced-serum/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/skinmedica/tns-advanced-serum/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/skinmedica/tns-advanced-serum/for/dark-spots
- France: https://lovi.care/skincare/fr/p/skinmedica/tns-advanced-serum/for/dark-spots (this page)
- Italy: https://lovi.care/skincare/it/p/skinmedica/tns-advanced-serum/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/skinmedica/tns-advanced-serum/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/skinmedica/tns-advanced-serum/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/skinmedica/tns-advanced-serum/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/skinmedica/tns-advanced-serum/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/skinmedica/tns-advanced-serum/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/skinmedica/tns-advanced-serum/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/skinmedica/tns-advanced-serum/for/dark-spots