# Sesderma Azelac RU Liposomal Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for France.

Brand: [Sesderma](https://lovi.care/skincare/fr/brands/sesderma)
Category: [Serums and treatments](https://lovi.care/skincare/fr/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers excellent skin brightening for your normal skin due to 4-butylresorcinol and tranexamic acid, which work to even skin tone, though the primary concern of wrinkles and fine lines is not directly addressed.
- Retinol and azelaic acid provide antioxidant and keratolytic actions beneficial for normal skin, while glycerin and tocopheryl acetate offer general hydration and soothing.
- The product is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/oily-acne-prone-skin): High

## Key ingredients

Azelaic Acid, Tranexamic Acid, Retinol, Niacin, 4-Butylresorcinol

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/))
- Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo. ([Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/))
- Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The 4-n-butylresorcinol dissolving microneedle patch demonstrated safety and was more than two times more effective than the control patch in skin depigmentation among 45 subjects over 8 weeks. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/26341915/))
- 4-n-butylresorcinol inhibits human tyrosinase and melanin production more potently than hydroquinone, arbutin, and kojic acid, and visibly reduces age spots within 8 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2013](https://pubmed.ncbi.nlm.nih.gov/23205541/))
- Combined application of dissolving microneedle patches on serum-treated skin successfully delivered more 4-n-butylresorcinol and showed higher efficacy in reducing patients' melanin index and hyperpigmented regions compared to traditional DMN-only and serum-only applications. ([Molecular Pharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/28447799/))

## Why other serums fit mature skin better

- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))

## What reviewers say

Based on limited data, users frequently report this serum effectively brightens the complexion and reduces hyperpigmentation like melasma, sun spots, and acne marks, leading to smoother and more luminous skin. Many appreciate its fast absorption and lightweight feel. Some users with sensitive or dry skin find it can be drying and recommend using a moisturizer.

- Liked: Fast absorption (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Acne control (sometimes noted)
- Disliked: Drying effect (sometimes noted)
- Disliked: High price (rarely noted)
- Disliked: Slow results (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Sesderma Azelac RU Liposomal Serum work for mature skin?

Sesderma Azelac RU Liposomal Serum works for mature skin as an average fit, because while it brightens skin and evens tone, it does not directly target wrinkles and fine lines. A product of this type needs to be exceptionally safe with no risk of irritation, effectively target wrinkles and fine lines with high-quality ingredients, and perform its intended anti-aging function excellently.

### Which ingredients make this serum a good fit for mature skin?

Retinol and azelaic acid make this serum a fit for mature skin by providing antioxidant action and smoothing the skin. To truly excel for mature skin, a product of this type needs ingredients that effectively target and reduce wrinkles and fine lines while improving elasticity and hydration.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### What does Azelaic Acid do for mature skin?

Azelaic acid helps mature skin by targeting dark spots and uneven tone, while supporting smoother texture and a more youthful look. It provides antioxidant benefits that may reduce signs of aging and protect skin from environmental stress.
Sources: [Frontiers in Medicine, 2026](https://pubmed.ncbi.nlm.nih.gov/42023095/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/36056802/)

### What does Tranexamic Acid do for mature skin?

Tranexamic acid helps reduce brown spots and uneven tone while improving overall skin brightness. Studies show that using it regularly can fade stubborn pigmentation safely and with very little irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38549196/), [Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing. A product of this type for mature skin also needs ingredients that directly target wrinkles and fine lines.

### Can I use this serum with vitamin C, and in what order?

You can use this serum with vitamin C, but it is best to apply vitamin C in the morning and save this treatment for the evening routine. This spacing helps avoid potential irritation from combining active ingredients while ensuring both can work effectively.

### How often should I use this serum?

This serum works well in your evening routine, starting at once a week to see how your skin responds before using it more often. A mature skin type needs products of this type to include ingredients that boost collagen and smooth fine lines, along with deeply nourishing and firming agents.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it is safe to use and free of harsh ingredients. However, to truly help mature skin with lines and wrinkles, this type of product needs ingredients like retinol and peptides that boost collagen and firm up the skin.

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol and alcohol denat).

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/fr/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/fr/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €139.99 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/fr/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — €599.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/fr/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/mature-skin) — Superior fit — €28.02 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/fr/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €18.45 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/fr/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €76.29 at Amazon

## Where to buy

No store in France has a checked price for this product, so the page shows none.

## Ingredients

Water, Lecithin, Propanediol, Alcohol, Bellis Perennis Flower Extract, Polymethyl Methacrylate, Peg-40 Hydrogenated Castor Oil, Propylene Glycol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, 4-Butylresorcinol, Alcohol Denat, Ascorbyl Glucoside, Azelaic Acid, Bha, Bht, Caprylic Capric Triglyceride, Carbomer, Citronellyl Methylcrotonate, Grapefruit Fruit Extract, Diacetyl Boldine, Dipotassium Phosphate, Disodium Edta, Disodium Phosphate, Ethylhexylglycerin, Glycerin, Glycyrrhetinic Acid, Hydrochloric Acid, Hydroxypropyl Cyclodextrin, Melissa Officinalis Leaf Extract, Morus Alba Root Extract, Niacin, Nicotiana Benthamiana Sh-Polypeptide-7, Parfum, Peg Ppg-20 6 Dimethicone, Phenethyl Alcohol, Phenoxyethanol, Polysorbate 20, Potassium Phosphate, Potassium Sorbate, Retinal, Retinol, Sodium Chloride, Sodium Cholate, Sodium Hydroxide, Tocopheryl Acetate, Tranexamic Acid, Triethanolamine, Triisopropanolamine, Undecylenoyl Phenylalanine, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin (this page)
- Italy: https://lovi.care/skincare/it/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin